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Korean Journal of Bone Metabolism 2010;17(1):25-29.
The Relationship between Serum Serotonin and Bone Mineral Density in Postmenopausal Women
폐경 후 여성에서 혈청 세로토닌 농도와 골밀도의 관계 연구
임준욱,진상욱,황유철,정인경,안규정,정호연
경희대학교 의과대학 동서신의학병원 내분비대사내과
Abstract
Objective
Recent studies have suggested that serotonin acts as a mediator of the bone metabolism and suppresses osteoblast proliferation by binding to its receptor in bone. Several studies reported that bone mineral density (BMD) was lower in those who used selective serotonin reuptake inhibitors (SSRIs) which increased extracellular serotonin levels. We investigated the relationship between serum serotonin and BMD.
Methods
Seventy six postmenopausal women with osteoporosis or osteopenia were enrolled in this study. We checked serum serotonin level to determine whether the high level of serotonin is associated with the lowering effect of BMD. In addition, the association between bone turnover markers (osteocalcin, C-terminal telopeptide of collagen cross-links, CTX) was investigated. BMD was measured at lumbar spine, femur neck and total hip by dual energy X-ray absorptiometry (DXA).
Results
There was negative correlation between serum serotonin and lumbar spine BMD (P = 0.0145). However, there was no statistically significant relationship between serotonin and other bone turn over makers.
Conclusion
Serum serotonin was significantly and negatively correlated with lumbar spine BMD. [Korean Journal of Bone Metabolism, 17(1): 25-29, 2010]
Key Words: Serotonin, Bone mineral density, Osteoporosis


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