Korean J Bone Metab > Volume 15(2); 2008 > Article
Korean Journal of Bone Metabolism 2008;15(2):127-133.
The Association of the Soft Tissue Calcification with Bone Mineral Density in Pre-menopausal Women
폐경 전 여성에서 연부조직의 석회화와 골밀도의 관련성
가톨릭대학교 성모병원 가정의학과
Atherosclerosis & osteoporosis are common degenerative diseases, and usually exist together. Therefore, many studies on relationships between them have been reported. Previous studies, however, were only focused on post-menopausal women and vascular calcification. The present study was designed to evaluate the association of bone mineral density (BMD) with calcification in various soft tissue including vessels in pre-menopause women.
Four hundred and sixty six pre-menopausal women who underwent medical check-up including bone density at a health examination center in a university hospital located in Seoul from January, 2006 to December, 2006 were included. Persons who had a history of oophorectomy, total hysterectomy, medically confirmed diseases such as thyroid, parathyroid, kidney, endocrine system, rheumatism, or were taking medicines, including hormones, affecting bone metabolism were excluded. Weight, height, body mass index (BMI), and body composition were measured by a bioelectric impedance device. Self-reported questionnaires asking about medical history and life styles were administered. Soft tissue calcifications were determined by simple chest X-ray, abdominal sonogram, and mammography or breast sonogram. Dual Energy X-ray Absorptiometry was used to measure the BMD of 2,3,4th lumbar vertebra and of trochanter, intertrochanter, and neck of femur. Simple regression analysis was used to find out confounders significantly associated with BMD, and multiple regression analysis was performed to evaluate the association between soft tissue calcifications and BMD.
Participants with soft tissue calcification were significantly older than those without soft tissue calcification (P=0.007). BMD at spine and total hip was positively and significantly associated with BMI, lean body mass, body fat, and weight (P < 0.001). Multiple regression analysis showed that soft tissue calcification had an interaction with age and was negatively associated with BMD at trochanter and intertrochanter of femur, and total hip (P < 0.05).
The results of the present study suggest that various soft tissue calcifications may be involved in both aging process and bone loss at total hip in pre-menopausal women. [Korean Journal of Bone Metabolism, 15(2): 127-133, 2008]
Key Words: Pre-menopausal, BMD, Soft tissue, Calcification


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