Olecranon Fractures Have Features of Osteoporotic Fracture

Seong Cheol Park; Hyun Sik Gong; Kahyun Kim; Seung Hoo Lee; Sehun Kim; Goo Hyun Baek

doi:10.11005/jbm.2017.24.3.175

jbm > Volume 24(3); 2017 > Article

Park, Gong, Kim, Lee, Kim, and Baek: Olecranon Fractures Have Features of Osteoporotic Fracture

Original Article

Journal of Bone Metabolism 2017;24(3):175-181.

Published online: August 31, 2017

DOI: https://doi.org/10.11005/jbm.2017.24.3.175

Olecranon Fractures Have Features of Osteoporotic Fracture

Seong Cheol Park¹, Hyun Sik Gong^1,², Kahyun Kim¹, Seung Hoo Lee¹, Sehun Kim¹, Goo Hyun Baek¹

¹Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea.

²Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Corresponding author: Hyun Sik Gong. Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173 beon-gil, Bundang-gu, Seongnam 13620, Korea.
Tel: +82-31-787-7198, Fax: +82-31-787-4056, hsgong@snu.ac.kr

Received June 09, 2017 Revised August 09, 2017 Accepted August 11, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

To determine whether olecranon fractures have osteoporotic features such as age-dependent, low bone attenuation and low-energy trauma as a cause of injury.

Methods

Elbow computed tomography (CT) and medical record review were performed in 114 patients (53 males and 61 females) with acute olecranon fractures. The mean age was 57 years. Bone attenuation was measured on the central part of the olecranon on sagittal CT images avoiding the fracture, and on the distal humerus (distal metaphysis and medial and lateral condyles) on coronal CT images. We compared bone attenuation and causes of injury (high or low energy trauma) between younger (<50 years) and older (≥50 years) patients in each gender. Multiple regression analysis was performed to determine the effect of age and gender on bone attenuation.

Results

Mean bone attenuation in older male and female patients was significantly lower than in younger patients, except at the medial condyle in men. The proportion of low-energy trauma in older male patients was significantly higher than in younger male patients. In female patients, low-energy trauma was predominant in both younger and older patients. Age and female gender had significantly negative effects on bone attenuation.

Conclusions

This study demonstrated that olecranon fractures have osteoporotic features, including age-dependent low bone attenuation and low-energy trauma as the predominant cause of injury. Our results suggest that osteoporosis evaluation should be considered for patients aged 50 years or more with olecranon fractures.

Key words: Olecranon · Osteoporosis · Osteoporotic fracture

INTRODUCTION

Osteoporosis, a serious systemic disease, is associated with increased morbidity, mortality, and economic cost.[1,2,3,4] Osteoporotic (fragility) fractures are fractures resulting from low-energy mechanical forces that would not normally result in a fracture according to National Institute for Health and Care Excellence clinical guidelines.[5] Several studies have suggested that the vertebrae, hip, proximal humerus, and distal radius fractures are major osteoporotic fractures.[4,6] Fractures of the femur diaphysis, ankle, and rib have also been included as osteoporotic fractures.[7,8,9,10] Previous studies have shown that history of an osteoporotic fracture is a risk factor of future fracture.[1,11,12,13,14,15] Therefore, patients with a prior fracture should receive further evaluation for osteoporosis and fracture risks.

Although fractures around the elbow are common,[16] there is less evidence showing that they have features of osteoporotic fracture. A few studies have mentioned that radial head and distal humerus fractures are potentially osteoporotic fractures. [17,18,19,20] However, whether olecranon fractures have osteoporotic features have not been evaluated yet. Therefore, the objective of this study was to determine whether olecranon fractures might have features of osteoporotic fracture such as age-dependent low bone attenuation and low-energy trauma as the cause of injury.

METHODS

1. Subjects

This study was approved by the Institutional Review Board of our hospital. We reviewed consecutive patients with acute olecranon fracture between March 2004 and February 2016 who were treated at our institution, an urban tertiary referral hospital. The inclusion criteria were: 1) acute olecranon fracture; 2) age of 20 years or more; and 3) available computed tomography (CT) scan of the elbow and medical record that documented the causes of injury. Exclusion criteria were: 1) avulsion fracture; 2) interval of more than 1 week between injury and CT examination; 3) CT scan taken at other hospitals; 4) rheumatoid arthritis, previous elbow trauma history, or any other conditions that could affect bone quality around the elbow.

A total of 114 patients who met the inclusion criteria were analyzed, including 53 males and 61 females. Their mean age was 57 years with standard deviation (SD) of 20 years. The causes of injury were categorized into high-energy trauma and low-energy trauma. Motorcycle accidents, car traffic accidents, fall from a height over a standing height, and sports accidents such as skiing were considered as high-energy trauma whereas slips and falls from a height less than a standing height were considered as low-energy trauma.[21]

2. CT measurement

Elbow CT examinations were performed using Brilliance iCT (Philips Healthcare, Cleveland, OH, USA) at 120 or 140 kVP with patient in supine position. CT images were obtained and measurements were performed using picture archiving and communication system (PACS). Bone attenuation was measured by placing a circular region of interest (ROI) on sagittal images of the olecranon and at the distal humerus (distal metaphysis and medial and lateral condyles) on coronal images where each region appeared to be the largest (Fig. 1). A circular ROI with a diameter of 3 mm was manually placed on the cancellous portion of each region while avoiding subchondral bone area and fracture line. Mean bone attenuation of each region was recorded as Hounsfield units (HU). Bone attenuations were measured by one of the authors who was blinded to the patient's information. For inter- and intra- observer reliability, CT images of 20 patients were selected randomly. For these 20 patients, the above-mentioned author measured bone attenuation once again after an interval of 4 weeks for intra-observer reliability. Another author measured the bone attenuation to determine inter-observer reliability.

3. Analyses

Patients were divided into two age groups. The older age group consisted of patients who were 50 years of age or older. The younger age group consisted of those who were less than 50 years old. We chose this age as a cut-off value because several previous studies have used the age of 50 as the cut-off value for osteoporosis evaluation. In addition, it has been reported that bone mineral density (BMD) remains fairly constant until about 50 years of age.[7,22,23,24,25] Bone attenuation between groups was compared using Student's t-test, after confirming the normality of the data by variance-equivalence test. The proportions of high- or low- energy trauma were compared between groups with χ² test.

The effects of age and gender on bone attenuation of the olecranon and the distal humerus were analyzed for all patients by multiple linear regression analysis. Independent variables were age and gender. Dependent variables were bone attenuations of the olecranon, lateral condyle, medial condyle, or the center of the distal humerus. In addition, the relationships between bone attenuation of the olecranon and age in both genders were assessed by spearman's correlation coefficient.

To determine the statistical power, primary outcome variable was bone attenuation on the olecranon. To determine a difference of 87 HU (50% of the mean bone attenuation) between two groups with a pooled SD of 82 HU (for an effect size of 1), a power analysis indicated that a sample size of 18 patients in each group would provide 80% statistical power to detect this effect size between groups (α=0.05, β=0.2) using t-test. Thus, the number of patients in each group of this study satisfied the statistical power. All statistical analyses were performed using the SPSS version 23.0 (SPSS Inc., Chicago, IL, USA). Statistical significance was considered when P-value was less than 0.05.

RESULTS

1. CT measurement

Mean bone attenuations of the olecranon, the lateral condyle of the distal humerus, the medial condyle, and the center were 174 (SD, 82), 130 (SD, 90), 117 (SD, 95), and 140 (SD, 69) HU, respectively. In male patients, the mean bone attenuation of the older age group was significantly lower than that of the younger age group in the olecranon (P=0.014), lateral condyle (P=0.013), and the center of the distal humerus (P=0.011) (Table 1). The difference in the medial condyle of the distal humerus was not statistically significant (P=0.056) between the two age groups. In female patients, the mean bone attenuations of the older age group were significantly lower than those of the younger age group in all measured areas (P<0.001).

2. Cause of injury

In male patients, the proportion of olecranon fractures caused by low-energy trauma in the older age group was significantly higher than that in the younger age group (P=0.033) (Table 2). In female patients, low-energy trauma was more common in both younger and older patients, with no significant intergroup difference (P=0.281).

3. Effect of age and gender on bone attenuation

Multiple linear regression analysis revealed that age and female gender independently had negative effect on bone attenuation (Table 3). In spearman's correlation coefficient, mean bone attenuation of the olecranon was negatively correlated with age in both male (r=-1.909, P=0.003) and female (r=-1.772, P<0.001) patients (Fig. 2).

4. Reliability of CT measurement

Intraclass correlation coefficient (ICC) values for intra- and inter- observer reliability are shown in Table 4. All ICC values were >0.8, indicating excellent inter- and intra- observer reliabilities.

DISCUSSION

Several studies have suggested that fractures of the vertebrae, hip, proximal humerus, and distal radius are major osteoporotic fractures. Fractures of the femur diaphysis, ankle, and rib also have features of osteoporotic fracture.[7,8,9,10,17,18,19,20] However, whether olecranon fractures have osteoporotic features has not been reported yet. This study demonstrates that olecranon fractures also have osteoporotic features such as age-dependent low bone attenuation and low-energy trauma as a cause of injury.

We used elbow CT as a surrogate examination of BMD at the olecranon and the distal humerus. Several studies have demonstrated that the average bone attenuation on CT of the spine is correlated with BMD on dual energy X-ray absorptiometry (DXA).[26,27,28] In addition, it has been reported that bone attenuation on CT of the ankle or the wrist can be used as marker of bone quality.[7,29,30] Romme et al.[26] have found that bone attenuation of the thoracic spine on routine chest CT is correlated strongly with BMD in patients with chronic obstructive pulmonary disease. They have reported that the attenuation threshold of 147 HU has the highest sensitivity and specificity for osteoporosis.[26] Schreiber et al.[27] have also evaluated CT of the distal radius and found that the attenuation threshold at 218 HU for females has optimum sensitivity and specificity for increased risk of distal radius fracture. Our results revealed that the mean bone attenuation of the elbow in women in the older age group ranged from 65 HU (SD, 43 HU) in the lateral condyle to 114 HU (SD, 35) in the olecranon, which were relatively low compared to the reported attenuation threshold HU values for osteoporosis in the thoracic spine or the wrist. Further studies correlating bone attenuation on elbow CT with BMD on DXA are needed to confirm their relationship and determine the HU threshold for detecting osteoporosis.

This study has several limitations. First, the number of patients was not large. In addition, patients included in this study were all Koreans recruited from a tertiary referral hospital. Therefore, the population in this study may not represent the general characteristic of all patients with olecranon fracture. However, evaluation with a single CT scanner made the measurement of bone attenuation reliable in this study. Second, this study did not involve control group. Elbow CT examinations could not be performed for age- and sex-matched patients without olecranon fracture because of radiation exposure. In addition, patients who had elbow CT scan without fracture had a certain condition that could affect bone quality such as rheumatoid arthritis. Third, analysis of bone attenuation involved only cancellous bone. However, both cancellous and cortical bones are important for mechanical strength. High-resolution peripheral quantitative CT that can quantify cortical porosity in vivo may further reveal cortical bone quality of the olecranon.[31] Fourth, olecranon fractures typically occur from a direct blow to the proximal ulna or indirectly from forceful contraction of the triceps against resistance during a fall. However, some fractures can occur when the elbow is hyperextended as the olecranon is impinged at the olecranon fossa of the distal humerus.[32] The exact mechanism of injury could not be confirmed in this study based on medical record. The injuries that involve contraction of the triceps or hyperextension of the elbow might not be classified into low or high-energy trauma based on the height of a fall. Further studies on injury mechanism and energy level needed to cause fracture are needed to determine whether such injuries are also osteoporotic fractures.

In conclusion, our results demonstrate that olecranon fractures have features of osteoporotic fracture, including age-dependent low bone attenuation in both genders and low-energy trauma as predominant cause of injury in men aged 50 years or more and in women regardless of younger or older. Our results suggest that patients aged 50 years or more with olecranon fracture should be evaluated for osteoporosis and fracture risks for secondary prevention of subsequent fractures.

ACKNOWLEDGEMENTS

This study was in part supported by a research fund (2015-R1D1A1A01058562) from National Research Foundation of Korea.

DECLARATIONS

No potential conflict of interest relevant to this article was reported.

References

1. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002;359:1761-1767.

2. Caliri A, De Filippis L, Bagnato GL, et al. Osteoporotic fractures: mortality and quality of life. Panminerva Med 2007;49:21-27.

3. Boonen S, Singer AJ. Osteoporosis management: impact of fracture type on cost and quality of life in patients at risk for fracture I. Curr Med Res Opin 2008;24:1781-1788.

4. Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 2004;34:195-202.

5. Rabar S, Lau R, O’Flynn N, et al. Risk assessment of fragility fractures: summary of NICE guidance. BMJ 2012;345:e3698.

6. Park C, Ha YC, Jang S, et al. The incidence and residual lifetime risk of osteoporosis-related fractures in Korea. J Bone Miner Metab 2011;29:744-751.

7. Lee KM, Chung CY, Kwon SS, et al. Ankle fractures have features of an osteoporotic fracture. Osteoporos Int 2013;24:2819-2825.

8. Barrett-Connor E, Nielson CM, Orwoll E, et al. Epidemiology of rib fractures in older men: Osteoporotic Fractures in Men (MrOS) prospective cohort study. BMJ 2010;340:c1069

9. Sajjan SG, Barrett-Connor E, McHorney CA, et al. Rib fracture as a predictor of future fractures in young and older postmenopausal women: National Osteoporosis Risk Assessment (NORA). Osteoporos Int 2012;23:821-828.

10. Ng AC, Drake MT, Clarke BL, et al. Trends in subtrochanteric, diaphyseal, and distal femur fractures, 1984-2007. Osteoporos Int 2012;23:1721-1726.

11. Klotzbuecher CM, Ross PD, Landsman PB, et al. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 2000;15:721-739.

12. Haentjens P, Autier P, Collins J, et al. Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women. A meta-analysis. J Bone Joint Surg Am 2003;85-a:1936-1943.

13. Tromp AM, Ooms ME, Popp-Snijders C, et al. Predictors of fractures in elderly women. Osteoporos Int 2000;11:134-140.

14. Kanis JA, Johnell O, De Laet C, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone 2004;35:375-382.

15. Earnshaw SA, Cawte SA, Worley A, et al. Colles’ fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone turnover rate. Osteoporos Int 1998;8:53-60.

16. Aitken SA, McQueen MM, Court-Brown CM. The epidemiology of fractures around the elbow joint. El Mednifico J 2014;2:189-194.

17. Kaas L, Sierevelt IN, Vroemen JP, et al. Osteoporosis and radial head fractures in female patients: a case-control study. J Shoulder Elbow Surg 2012;21:1555-1558.

18. Palvanen M, Kannus P, Niemi S, et al. Secular trends in the osteoporotic fractures of the distal humerus in elderly women. Eur J Epidemiol 1998;14:159-164.

19. Kinik H, Atalar H, Mergen E. Management of distal humerus fractures in adults. Arch Orthop Trauma Surg 1999;119:467-469.

20. Yoo JH, Moon SH, Ha YC, et al. Osteoporotic fracture: 2015 position statement of the Korean society for bone and mineral research. J Bone Metab 2015;22:175-181.

21. Sanders KM, Pasco JA, Ugoni AM, et al. The exclusion of high trauma fractures may underestimate the prevalence of bone fragility fractures in the community: the Geelong Osteoporosis Study. J Bone Miner Res 1998;13:1337-1342.

22. Briançon D, de Gaudemar JB, Forestier R. Management of osteoporosis in women with peripheral osteoporotic fractures after 50 years of age: a study of practices. Joint Bone Spine 2004;71:128-130.

23. Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007;370:657-666.

24. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002;359:1929-1936.

25. Compston J, Cooper A, Cooper C, et al. Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 2009;62:105-108.

26. Romme EA, Murchison JT, Phang KF, et al. Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD. J Bone Miner Res 2012;27:2338-2343.

27. Schreiber JJ, Anderson PA, Rosas HG, et al. Hounsfield units for assessing bone mineral density and strength: a tool for osteoporosis management. J Bone Joint Surg Am 2011;93:1057-1063.

28. Batawil N, Sabiq S. Hounsfield unit for the diagnosis of bone mineral density disease: a proof of concept study. Radiography 2016;22:e93-e98.

29. Johnson CC, Gausden EB, Weiland AJ, et al. Using hounsfield units to assess osteoporotic status on wrist computed tomography scans: comparison with dual energy X-ray absorptiometry. J Hand Surg Am 2016;41:767-774.

30. Schreiber JJ, Gausden EB, Anderson PA, et al. Opportunistic osteoporosis screening - gleaning additional information from diagnostic wrist CT scans. J Bone Joint Surg Am 2015;97:1095-1100.

31. Zebaze R, Ghasem-Zadeh A, Mbala A, et al. A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone 2013;54:8-20.

32. Wiegand L, Bernstein J, Ahn J. Fractures in brief: olecranon fractures. Clin Orthop Relat Res 2012;470:3637-3641.