| A Case of Paget s Disease Diagnosed before Age of 40,
Treated with Intravenous Bisphosphonate |
| 40세 이전에 진단된 파제트병 (Paget s Disease)의 치료 1예 |
| 이성자,송하도,양문석,공성열,김대영,박소영,임창훈,김성훈,한기옥,윤현구 |
| 관동대학교 |
|
|
| Abstract |
|
Paget s disease of bone is a chronic affliction of the adult skeleton featuring one or more area of aggressive osteoclastmediated
bone resorption preceding imperfect osteoblast-mediated bone repair. Most patients are asymptomatic.
Symptoms vary according to the extent and site of bone involvement. Frequently affected bones are the pelvis, spine,
skull, and long bones. The two most common clinical manifestations are pain and deformities in affected areas.
Paget s disease of bone shows a strong age-dependency. Marked geographical differences in prevalence of the
disease exist; that is common in the UK and United States. Conversely, extremely rare in the Korea. Treatment of
Paget's disease has several different therapeutic tools. Bisphosphonates, which decrease bone resorption by inhibiting
osteoclast resorption, are the treatment of choice. We report a case of Paget's disease in 36 year-old woman who
showed improvement in the symptoms and the serum alkaline phosphatase level after treatment with zoledronate and
pamidronate. [Korean Journal of Bone Metabolism, 17(2): 109-113, 2010] |
| Key Words:
Paget s disease, Pamidronate, Zoledronate |
|
PDF Links
Full text via DOI
Download Citation
