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Predictors of Acute Phase Response after Intravenous Zoledronic
Acid in Patients with Osteoporotic Fracture |
Young-Kyun Lee1 Ji Hoon Baek Yong-Chan Ha* Kyung-Hoi Koo1 |
Department of Orthopaedic Surgery, College of Medicine, Chung-Ang University, Seoul, South Korea
Department of Orthopaedic Surgery1, College of Medicine, Seoul National University Bundang Hospital, South Korea |
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Abstract |
Objective Acute phase response (APR) is the most common adverse event of the intravenous zoledronic acid, and
can reduce the compliance of annual injection. The purpose of this study is to determine the predictor of APR after 5
mg zoledronate in patients with osteoporotic fractures.
Methods In this prospective study, patients admitted with osteoporotic fracture, > 50 years of age, and who were
willing to receive zoledronic acid during hospital stay were eligible. During hospital stay, we prospectively evaluated
APR, including fever, flu-like symptoms, headache, arthralgia, and myalgia, after 5 mg zoledronate. We evaluated the
predictors in demographic data by multivariate analysis.
Results In this study of 159 patients with osteoporotic fractures, the frequency of APR, fever was 32.1%, and 22.0%.
The significant predictor of APR were higher bone mass index (BMI) and male gender in multivariate analysis,
especially in terms of fever.
Conclusion This study showed that predictors of APR after intravenous zoledronic acid are male gender and higher
BMI. Although those were uncorrectable factors before intravenous administration, these concerns on the APR such
as fever can reassure the predictive patients, and minimize compliance decreases.
[Korean Journal of Bone Metabolism, 17(2): 103-107, 2010] |
Key Words:
Acute phase response, Predictor, Zoledronic acid |
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