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Korean Journal of Bone Metabolism 2008;15(2):155-161.
The Effects of Black Cohosh Root Extract on the Vasomotor Symptom and Bone Metabolism of Postmenopausal Women
폐경기 여성에서 승마물질이 급성 폐경 증상과 골밀도에 미치는 영향
노명숙1,오영림1,김흥열1,어완규2,김홍배3
고신대학교 복음병원1, 경희대학교 동서신의학병원2, 한림대학교 강남성심병원3
Abstract
Objective
To evaluate the effect of black cohosh root extract (BCRE) on vasomotor symptoms and bone mineral density in postmenopausal women Method: This prospective randomized clinical trial examined the effects of BCRE on vasomotor symptom, bone mineral density (BMD), and biochemical markers of bone turnover in 90 postmenopausal women. Treatment included BCRE (group I, n=30), 0.625 mg conjugated equine estrogen (CEE) (group II, n=30), and control group (group III, n=30) for 6 months. Kupperman index, BMD and biochemical bone marker were measured at 0, 3 and 6 months after treatment.
Results
Kupperman index decreased significantly at 6 months and 12 months after treatment in group I and II (P < 0.05). BMD of lumbar spine increased significantly after treatment in group I and II (P < 0.05). Urinary deoxypyridinoline decreased significantly at 6 and 12 months after treatment in group I and group II (P < 0.05).
Conclusion
BCRE appears to be an effective alternate to hormone therapy for vasomotor symptom, and it may be especially useful in women with intolerance or contraindication to traditional hormone therapy. [Korean Journal of Bone Metabolism, 15(2): 155-161, 2008]
Key Words: Black Cohosh, Kupperman index, Bone mineral density, Markers, biochemical


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