Objective
The aim of the study is to assess the effect of 1-year treatment with tibolone on bone mineral density (BMD) in postmenopausal women with osteopenia or osteoporosis.
Methods
Sixty-two postmenopausal women with osteopenia or osteoporosis were enrolled to a prospective study of treatment with 2.5 mg per day of tibolone for a year. BMD of lumbar spine (L2-L4) was assessed by dual energy absortiometry at baseline, 6 months, and 12 months after treatment. Serum follicle stimulating hormone (FSH) and estradiol (E2) level were also assessed at baseline and 12 months after treatment.
Results
BMD at the studied site after 12 months of tibolone (0.82 ± 0.10 g/cm2) was significantly higher as compared to baseline (0.77 ± 0.10 g/cm2). The gain of BMD was +5.1%. Serum FSH and E2 values remained relatively stable as compared to baseline.
Conclusion
This study suggests that tibolone treatment in postmenopausal women with osteopenia or osteoposis is effective in terms of improving BMD. [Korean Journal of Bone Metabolism, 15(2): 151-154, 2008]
