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Korean Journal of Bone Metabolism 2008;15(2):143-149.
Dietary Calcium Intake and Bone Metabolism in Korean Postmenopausal Women
폐경 후 한국 여성의 칼슘 섭취와 골대사 지표에 관한 연구
장정윤,정호연,황유철,정인경,안규정,권미광,전 숙,오승준,우정택,김성운,김진우,김영설
경희대학교 의과대학 내분비대사내과
There is a consensus that adequate calcium intake helps to prevent bone resorption and osteoporosis especially in person with low calcium diets. Even though people are concerned about bone health and are encouraged to take calcium supplementation, we believe that most people do not have enough calcium in their diets. The purpose of this study was to determine the nutritional status, urine calcium, bone markers and their relationship in Korean postmenopausal women. Subjects: The subjects were 56 healthy female with postmenopausal osteopenia and osteoporosis (mean age, 57.7 years). Dietary calcium, phosphorus and protein were measured by 24 hrs recall method and urine calcium, bone markers, 25-OH D were measured in the fasting state.
The mean (SD) daily dietary intakes of Ca, P, protein were 616 (211.9) mg, 1002 (258.6) mg, 64.8 (16.7) g respectively. Only 6.5% of the participants had calcium intake of more than 1000 mg. 55.4% of the subjects showed 25-OH D of less than 30 ng/ml. The subjects showing hypercalciuria were 29.1%. Multiple regression analysis showed that urinary calcium excretion was associated with serum P, CTX, 25-OH D but not calcium intake. The mean value of 24 hr-urine calcium was 0.22 g and it was significantly decreased into 0.18 g after 6 month supplementation of 500 mg of elemental calcium and 400 IU of vitamin D. 57.2% of the hypercalciuric subjects showed normocalciuria after supplementation. An average 24 hour-urine calcium excretion decreased among hypercalciuric subjects after supplementation of calcium and vitamin D. However, an average 24 hour-urine calcium excretion among normocalciuric subjects did not change after supplementation of calcium and vitamin D. CTX, bone resorption marker was significantly decreased and spine BMD was significantly increased supplementation for 6 months.
Nutritional support including calcium supplementation should be required for the most postmenopausal women and should be required for the most persons who are interested in improving bone health. [Korean Journal of Bone Metabolism, 15(2): 143-149, 2008]
Key Words: Calcium intake, Calcium excretion, Biochemical markers, BMD


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