Korean J Bone Metab Search

CLOSE


Korean Journal of Bone Metabolism 2008;15(2):91-98.
Diabetes and Osteoporosis
당뇨병과 골다공증
오기원
성균관대학교 의과대학 내과학교실
Abstract
Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea Longer life expectancy and increased obesity contribute to an increasing incidence of diabetes mellitus and osteoporosis. Recent meta-analyses and cohort studies confirm that diabetes is associated with higher fracture risk. Patients with type 2 diabetes display an increased fracture risk despite a higher bone mass, which is mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of the absence of the anabolic effects of insulin and IGF-1 system. Several clinical studies have reported adverse skeletal actions of PPARγ agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but by modulating adipokines which are known to affect bone remodeling. [Korean Journal of Bone Metabolism, 15(2): 91-98, 2008]
Key Words: Osteoporosis, Diabetes, Obesity, Insulin, IGF-1, PPARγ, Adipokine


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#1001, Hyundai Kirim Officetel, 42 Seocho-daero 78-gil, Seocho-gu, Seoul 06626, Korea
Tel: +82-2-3473-2231    Fax: +82-70-4156-2230    E-mail: editors.jbm@gmail.com                

Copyright © 2021 by The Korean Society for Bone and Mineral Research.

Developed in M2PI

Close layer
prev next