Diabetes and Osteoporosis

Korean J Bone Metab > Volume 15(2); 2008 > Article

Review Article

Korean Journal of Bone Metabolism 2008;15(2):91-98.

Diabetes and Osteoporosis

당뇨병과 골다공증

오기원

성균관대학교 의과대학 내과학교실

Abstract

Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea Longer life expectancy and increased obesity contribute to an increasing incidence of diabetes mellitus and osteoporosis. Recent meta-analyses and cohort studies confirm that diabetes is associated with higher fracture risk. Patients with type 2 diabetes display an increased fracture risk despite a higher bone mass, which is mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of the absence of the anabolic effects of insulin and IGF-1 system. Several clinical studies have reported adverse skeletal actions of PPARγ agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but by modulating adipokines which are known to affect bone remodeling. [Korean Journal of Bone Metabolism, 15(2): 91-98, 2008]

Key Words: Osteoporosis, Diabetes, Obesity, Insulin, IGF-1, PPARγ, Adipokine