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Korean Journal of Bone Metabolism 2008;15(1):77-83.
Association of Prostaglandin-Endoperoxide Synthase 2 (PTGS2) Polymorphism with Bone Mineral Density (BMD) in Postmenopausal Women
폐경 여성에서 Prostaglandin-Endoperoxide Synthase 2 (PTGS2) 유전자 다형성과 골밀도의 상관관계
이승훈,고정민,박병래1,신형두1,김태호2,박의균2,김신윤2,김기수
울산대학교 의과대학 서울아산병원 내분비-대사 내과, 에스엔피제네틱스 (주)유전역학부1, 경북대학교병원 골격계 질환유전체연구센터2
Abstract
Objective
Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulator of bone metabolism, by mediating osteoclastogenesis, mechanotransduction, bone formation and fracture repair. We examined the association between PTGS2 gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women.
Methods
From the results of previous reports, we selected two polymorphisms, that is, -1329A>G at the promoter region and +6365T>C at the 3'-untranslated region, and we genotyped -1329A>G using single-base extension (SBE) reaction and +6365T>C using TaqMan method. BMD at the lumbar spine and femur neck was measured using dual energy X-ray absorptiometry.
Results
Mean age for the subjects was 58.9 years old. The frequencies of the minor alleles of the two polymorphisms were 47.4% for -1329G, and 20.3% for +6365C. Both polymorphisms were in compliance with Hardy-Weinberg equilibrium. PTGS2 -1329A>G didn't show any significant correlations with the BMD in either site, and PTGS2 +6365T>C didn't show any significant correlation with lumbar spine BMD. Multiple regression analysis showed that PTGS2 +6365T>C polymorphism was associated with BMD at the femur neck, even after controlling for age, weight, height, and years since menopause (P=0.03). The subjects with C allele had significantly lower femur neck BMD than those with T homozygote.
Conclusion
These findings indicate that PTGS2 could be a candidate gene for the determinant for BMD in Korean postmenopausal women.
Key Words: Bone density, Polymorphism, Postmenopausal women, Prostaglandin-endoperoxide synthase 2


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