Korean J Bone Metab > Volume 8(2); 2001 > Article
Korean Journal of Bone Metabolism 2001;8(2):123-129.
Lack of Association between Bone Mineral Density and ER Gene Polymorphism in Korean Young Men
한국인 젊은 남성에서 골밀도와 에스트로젠 수용체 유전자 다형성과의 상관관계
울산대학교 의과대학 서울중앙병원 내과, 핵의학과1, 아산생명과학연구소2
Previous studies suggested an importance of estrogen on bone mass and a relationship between polymorphism of the estrogen receptor  (ER) gene and bone mineral density (BMD) in men. We investigated the association between BMD and ER gene polymorphism, PvuII and XbaI genotypes in the first intron of ER gene in a prospective study of 157 Korean young men, aged 25.3±3.7 years. Areal BMD was measured by dual-energy X-ray absortiopmetry at the lumbar spine, femoral neck, Trochanter, Ward's triangle and femoral shaft in young healthy Korean men. ER genotype was determined by polymerase chain reaction (PCR) analysis of genomic DNA. The PCR products were digested with PvuII and XbaI. The prevalence of PvuII gene polymorphisms was 19.1% for PP, 43.3% for Pp and 37.6% for pp, respectively, and that of XbaI was 5.1% for XX, 36.3% for Xx and 58.6% for xx, respectively. No significant association was found between BMD and either PvuII or XbaI genotypes, after adjustment for age and body mass index. Further analysis of ER polymorphisms according to Px haplotypes failed to demonstrate possible association with BMD. These data do not support the hypothesis that there is an association between ER genotype and BMD in Korean young men.
Key Words: Estrogen receptor, Polymorphism, Peak bone mass, Man, Bone mineral density


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