Background
Osteoporosis is characterized by low bone mass and characterized deterioration of bone tissue, with subsequent increase in bone fragility and susceptibility to fracture and is one of the most significant long term sequelae of menopause.
Methods
Hormone replacement therapy (HRT) preserve bone mineral density (BMD) in most menopausal women, but there are variations in response. To evaluate the impacts of HRT on bone mineral density between surgical and natural menopausal women, we designed this study.
Results
The purpose of this study was to compare effectiveness of HRT in surgical menopause with it in natural menopause. BMD was assessed 85 surgically menopausal women at the time of starting HRT and was repeated after one year HRT. Lumbar BMD 12 months after treatment increased significantly from baseline value (p<0.01) in natural menopausal women, but decreased significantly from baseline value in surgically menopausal women. Femur neck BMD 12 month after treatment increased significantly from baseline value (p<0.01) in natural menopausal women, but decreased from baseline value in surgically menopausal women.
Conclusions
Usual dosages of HRT cannot prevent acute bone loss effectively after both oophorectomized women. So additional therapy will be prescribed to surgically menopausal women.
