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Korean Journal of Bone Metabolism 2001;8(1):43-48.
Osteoprotegerin Polymorphism, Bone Mineral Density and Bone Turnover Markers in Korean Postmenopausal Women
한국인 폐경후 여성에서 Osteoprotegerin 유전자 다형성과 골밀도 및 골대사 지표
김윤이,정호연,황창선1,오한진2,최규홍3,이득주4,이창욱,김해성,황지주,임창훈,한기옥,장학철,윤현구,한인권
성균관대학교 의과대학 삼성제일병원 내과, 내분비 연구실1, 가정의학과2, 산부인과3, 유타대학4
Abstract
Background
The identification of genes that impact on the bone mineral density (BMD) and rates of bone loss has widespread implications for the understanding and prevention of osteoporosis. Osteoprotegerin (OPG), a TNF receptor family member, has been shown both in vitro and in vivo to inhibit osteoclast differentiation and activation. Transgenic mice overexpressing OPG have high levels of OPG protein in their systemic circulation and exhibit a marked increase in bone density. OPG-deficient mice develop early onset osteoporosis and arterial calcification. These findings suggest that OPG may be an important regulator of bone mass and bone metabolism. The aim of this study was to assess the relationship of OPG gene polymorphism with BMD and rate of bone turnover.
Methods
Polymorphism at the promotor region of OPG was evaluated after PCR amplification of genomic DNA and Hinc II restriction enzyme digestion. The OPG genotype was determined in 133 Korean postmenopausal women (mean age: 53.4±5.1 years). BMD at the lumbar spine and the hip was examined by DEXA. Bone turnover markers including osteocalcin, deoxypyridinoline, and morning spot urine calcium/creatinine ratio were measured.
Results
In the cohort 21 individuals were homozygous for the CC genotype, 22 were heterozygous and 90 individuals were homozygous for the TT genotype. No differences were found between genotypes in age, height, weight, age at menarche or menopause, BMD at any site. Also, no significant genotypic differences were found in the bone turnover markers except spot urine/creatinine ratio. Among the groups, the CC genotypes had the highest calcium excretion ratio.
Conclusion
We conclude that OPG polymorphism does not appear to be associated with BMD. OPG genotype might be involved in calcium metabolism.
Key Words: OPG, Polymorphism, BMD


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