Korean J Bone Metab > Volume 9(2); 2002 > Article
Korean Journal of Bone Metabolism 2002;9(2):171-176.
The Effect of Periodic Therapy of Combined Tibolone, Synthetic Salmon Calcitonin and Calcium in Osteoporotic Postmenopausal Women
폐경기 골다공증 여성에서의 티볼론, 합성 칼시토닌, 칼슘제재 주기적 병용 투여에 따른 치료 효과
단국대학교 의과대학 정형외과학교실
Our study was designed to analyze the synergic effect after 2 times combined periodic therapy of tibolone, synthetic nasal spray type salmon calcitonin and calcium for 3 months each.
This study was based on 21 patients among 168 patients treated osteoporotic drug (combination therapy of tibolone, synthetic salmon calcitonin, calcium agent) from March 1995 to October 1999, with a minimum follow up 1 year. We compared preoperative bone mineral density (BMD) with postoperative BMD and laboratory finding (ionized calcium, phosphate, alkaline phosphatase in serum and calcium/creatinine ratio in urine) which were statistically analyzed.
BMD was increased in spine (0.62 g/cm2 to 0.65 g/cm2) and not increased in hip (neck: 0.60 g/cm2 to 0.60 g/cm2, trochanter: 0.55 g/cm2 to 0.48 g/cm2, Ward's triangle: 0.37 g/cm2 to 0.38 g/cm2), but was not statistically significant (p>0.05). The laboratory finding was tendency of decreased bone metabolism (ionized calcium: 9.6 mg/dl to 9.3 mg/dl, phosphate: 4.2 mg/dl to 3.7 mg/dl, ALP: 99.9 IU/L to 83.0 IU/L in serum and calcium/creatinine ratio in urine: 10.9 to 9.1), but was not statistically significant (p>0.05).
In the osteoporotic post-menopausal women, the periodic combined therapy of tibolone, calcitonin and oral calcium agent did not show the syndergic effect in BMD and bone metabolism. This periodic combined therapy does not recommandable to osteoporotic post-menopausal women.
Key Words: Osteoporosis, Tibolone, Calcitonin, Bone mineral density, Bone metabolism


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