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Korean Journal of Bone Metabolism 2004;11(1):19-24.
Lack of Association between Homocysteine Levels and Bone Mineral Density in Healthy Premenopausal and Postmenopausal Women
건강한 폐경 전후 여성에서 혈청 호모시스테인 농도와 골밀도와의 상관관계
배성진,손현영,김덕재,정윤이1,고정민,김기수
울산대학교 의과대학 서울아산병원 내과학교실, 서울보훈병원 내과1
Abstract
Background
Recently, elevated serum homocysteine levels have been reported to be associated with increased fracture risk and low broadband ultrasound attenuation of heel in elderly men and women. We investigated associations between serum homocysteine levels and bone mineral density (BMD) in healthy Korean women.
Methods
The study population was comprised of 409 healthy premenopausal and postmenopausal Korean women. BMD at the lumbar spine and femoral neck were measured by dual energy x-ray absorptiometry. Serum concentrations of homocysteine were measured with an competitive immunoassay using direct, chemiluminescent technology.
Results
Serum concentrations of homocysteine were significantly higher in postmenopausal than in premenopausal women (p<0.001). After the adjustment for confounding variables, we did not observe a significant correlation between serum homocysteine levels and BMD in total subjects (β=-0.024, p=0.605 for lumbar spine; β=-0.033, p=0.491 for femoral neck). With the analyses by menopausal status, there were still no significant associations between serum homocysteine levels and BMD in both premenopausal and postmenopausal women.
Conclusion
Measurement of serum homocysteine may not be useful for the risk assessment of osteoporosis.
Key Words: Homocysteine, Osteoporosis, Bone mineral density, Women


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