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Korean Journal of Bone Metabolism 2005;12(2):171-177.
Association between the Marker of Oxidative Stress (8-Hydroxydeoxyguanosine) Levels and Bone and Mineral Metabolism in Healthy Postmenopausal Women
건강한 폐경 후 여성에서 혈청 산화스트레스 표식자와 골밀도 및 골대사와의 상관 관계
가톨릭대학교 의과대학 내과학교실, 성균관대학교 의과대학 강북 삼성병원 내과학교실1, 한림대학교 의과대학 평촌 성심병원 내과학교실2
Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, can cause damage to DNA, protein and lipids. Oxidative stress has been implicated in a wide variety of disease processes, including atherosclerosis, diabetes, neurodegerative disorder and process of aging. Recently, it has been also suggested that oxidative stress is causally associated with pathogenesis of osteoporosis. In this study, we investigated the association between the marker of oxidative stress and either the bone turnover markers and bone mineral density (BMD).
Oxidative stress was evaluated in serum by measurement of 8-hydroxy-2-deoxyguanosine (8-OHdG) in 135 postmenopausal subjects (68.2±4.9 years, BMI 24.4±2.8 kg/m2). Women who had taken drugs which affected bone metabolism and who had past history of smoking were excluded. The biochemical markers of bone formation (osteocalcin) and resorption (carboxy-terminal telopeptide of type I collagen (ICTP)) were measured from the same specimen. BMD of lumbar spine, and hip were measured by dual energy X-ray absorptiometry.
In multivariate linear regression analyses, the 8-OHdG levels were negatively associated with BMD of lumbar spine, total proximal femur, femoral neck, trochanter, and positively associated with the ICTP levels. Odds ratio (OR) of the 8-OHdG for osteoporosis in lumbar spine and osteoporosis and/or osteopenia in total proximal femur were 1.70 (1.20~2.39, p=0.003) and 1.36 (0.97~1.91, p=0.043), respectively. OR for increased bone resorption was 4.22 (1.44~7.72, p=0.009) in the highest 8-OHdG quantile.
These findings suggest that oxidative stress is associated with increased bone resorption and low bone mass in healthy women.
Key Words: Oxidative stress, 8-Hydroxydeoxyguanosine, Bone mineral density, Osteoporosis


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