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Korean Journal of Bone Metabolism 2005;12(2):153-161.
Associations of Catalase Polymorphism with Bone Mineral Density and Serum Osteocalcin Levels in Postmenopausal Women
폐경후 여성에서 Catalase 유전자 다형성과 골밀도 및 혈청 오스테오칼신 농도의 상관관계
김덕재,고정민,김기수
울산대학교 의과대학 서울아산병원 내분비내과
Abstract
Background
Oxidative stress has been recently suggested to play a role in the development of osteoporosis because it decreases bone formation and stimulates bone resorption. Catalase is a major antioxidant enzyme that detoxifies hydrogen peroxide by converting it into water and oxygen thereby preventing cellular injury by oxidative stress. We hypothesized that certain catalase polymorphisms may result in reduced enzyme activity and therefore affect bone metabolism by reducing the reserve for oxidative stress. To investigate this possibility, we examined the associations between catalase polymorphisms and bone mineral density (BMD) and serum osteocalcin levels in healthy postmenopausal women.
Methods
All exons, their boundaries, and the promoter region (approximately 1.5 kb) of catalase were directly sequenced in 24 individuals. Among 18 variants identified, 4 variants were selected and genotyped in all study participants (n = 560). BMD at the lumbar spine and proximal femur was measured using dual energy X-ray absorptiometry. Serum osteocalcin levels were determined by immunoradiometric assay.
Results
The mean age of the subjects was 59.4±7.2 years. Multivariate analysis showed an association of the 22348 C>T polymorphism (frequency 0.42) with BMD at the lumbar spine and serum osteocalcin level. Individuals with the T allele showed significantly higher lumbar spine BMD (0.861±0.173 vs. 0.819±0.174 g/cm2, p=0.01) and lower osteocalcin levels (28.8±11.3 vs. 32.1±12.7 ng/ml, p=0.008) than those without this allele.
Conclusion
These findings indicate that the 22348 C>T polymorphism of catalase may be a genetic predictor of osteoporosis.
Key Words: Catalase, Polymorphism, Bone density, Osteocalcin, Postmenopausal women


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