| Hypercalcemia Induced by Ovarian Clear Cell Carcinoma Producing Parathyroid Hormone-related Peptide (PTHrP) |
| 투명 세포 난소암 환자에서 부갑상선 호르몬 관련 펩티드에 의하여 유발된 고칼슘혈증 - 증례 보고 - |
| 유성훈,김태선,송민준,김헌성,장유진,박지영1,임창훈,황일순,윤현구,한기옥 |
| 성균관대학교 의과대학 제일병원 내과, 조직병리과1 |
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| Abstract |
Background
Parathyroid hormone-related peptide (PTHrP) appears as the major causative agent responsible for the humoral hypercalcemia of malignancy (HHM). However, the use of promoters and splicing patterns of PTHrP gene in the HHM have not been reported yet.
Case: A 35-year-old woman was diagnosed as having an ovarian clear cell carcinoma with the HHM caused by elevated serum PTHrP after delivery. An immunohistochemical study showed PTHrP expression in tumor tissue. The Southern blot analysis following RT-PCR confirmed the presence of all types of PTHrP mRNA transcripts produced by a combination of three promoters, one 5' alternative splicing and three alternative 3' splicing events.
Conclusion
An ovarian clear cell carcinoma induced PTHrP-related HHM, which resulted from the high expression of all isoforms for PTHrP gene.
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| Key Words:
Ovarian cancer, Clear cell carcinoma, Humoral hypercalcemia of malignancy, Parathyroid hormone-related peptide |
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