| The Clinical Efficacy and Safety of Glucosamine Sulfate Compound in the Korean Middle Aged Women with Osteoarthritis of the Knee |
| 중년의 퇴행성 슬관절염 여성 환자에서 Glucosamine Sulfate 복합제제와 Naproxen Sodium의 3개월 치료 효과 및 안정성 비교 |
| 이기호12,김은기3,전선영1,안유헌1 |
| 한양대학교 의료원 성인병센터, 종합검진센터1, 연세대학교 노화과학연구소2, 대전선병원 종합검진센터3 |
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| Abstract |
Object: This research was designed to investigate the clinical efficacy and safety of Neoflex? versus naproxen sodium 275 mg in Korean middle-aged women with osteoarthritis of the knee.
Methods
A prospective randomized clinical trial was perfomed. A total of 29 patients with knee osteoarthritis were included into this study and divided either into Neoflex? (n=15) or naproxen sodium group (n=14). The subjects received once daily oral glucosamine compound (glucosamine 1600 mg, shark cartilage 300 mg, omega3 fatty acid 5 mg, Yucca power extract 3 mg, bromelein 1 mg, vitamin A 80 IU, vitamin C 2 g and vitamin E 2 IU) or twice naproxen sodium 275 mg for 12 weeks. Clinical efficacy was evaluated at baseline and after 12 weeks of treatment by using Lysholm knee score, WOMAC index, 100 mm Visual Analogue Scale for pain, Lequesne index and passive ROM.
Result: After 12 weeks of therapy, both groups had significant improvement (p<0.05) in VAS, WOMAC, Lysholm knee score, Lequesne index except for passive ROM than baseline although the difference between two groups did not reach statistical significance (p>0.05). The incidence of gastrointestinal adverse events was lower in glucosamine compound than naproxen sodium group. Conclusion: Glucosamine compound is comparable to naproxen sodium in the treatment of Korean middle-aged women with osteoarthritis of the knee. Furthermore glucosamine compound was well tolerated for 12 weeks without any serious side effects. There is need for further studies on a large number of subjects to see how radiologic and functional scale might be changed after treatment with glucosamine compound.
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| Key Words:
Glucosamine, Chondroitin, omega3 fatty acid, Naproxen sodium, Osteoarthritis |
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