Korean J Bone Metab > Volume 14(1); 2007 > Article
Korean Journal of Bone Metabolism 2007;14(1):27-32.
Clinical analysis of Bone Mineral Density and Hormone Replacement in Young Women with Turner Syndrome
터너 증후군 환자에서 골밀도와 호르몬 요법에 관한 임상적 고찰
가톨릭대학교 의과대학 산부인과학교실
Most girls with Turner syndrome (TS) need hormone replacement treatment (HT) to induce and maintain feminization and prevent osteoporosis. There is abundant information on HT use in postmenopausal women, but little is known about this issue in women with TS. This study aimed to analyze the effects of hormone replacement on bone mineralization in patients with TS by measuring bone mineral density (BMD).
Thirty women were diagnosed as TS during last 10 years at Kangnam St. Mary's hospital, the Catholic University of Korea. All of their medical records about HT and bone mineral density were reviewed.
Fifteen women with TS had received HT HT was started at the age of 25.27 ± 5.95. The mean duration of HT was 9.73 ± 7.36 years. At the time when HT was started, lumbar BMD and right femur BMD in the TS patients were 0.78 ± 0.12 g/cm2 and 0.62 ± 0.08 g/cm2, respectively. The mean Z scores in lumbar spine and femur neck were -2.34 ± 0.86 and -2.76 ± 0.81, respectively. However, lumbar BMD and right femur BMD were significantly increased (0.91 ± 0.13 g/cm2 and 0.73 ± 0.11 g/cm2) after one year of HT (P < 0.005).
It was suggested that hormone replacement therapy was delayed in women with Turner syndrome, and bone mineral density of those patients was much lower than that of age-matched normal women. However, HT could increase bone mineral density in the spine and femur. Therefore, we can conclude that the optimal HT during childhood and adolescence should be established as soon as possible. It is important to emphasize to young women with TS and their caregivers that HT is critical for bone health.
Key Words: Turner syndrome, BMD, Osteoporosis, Hormone therapy


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