Korean J Bone Metab > Volume 14(1); 2007 > Article
Korean Journal of Bone Metabolism 2007;14(1):11-17.
Relationship of Serum Adiponectin Levels with Circulating Osteoprotegerin/Receptor Activator of NF-κB Ligand System in Men
성인 남성에서 혈청 아디포넥틴 농도와 순환하는 Osteoprotegerin/Receptor Activator of NF-κB Ligand 계의 관련성
오기원,윤은주1,정찬희,이은정,박철영,이원영 한제호2 박성우
성균관대학교 의과대학 내과학교실, 한림대학교 의과대학 방사선과학교실1, 가톨릭대학교 의과대학 내과학교실2
Weight is an important determinant of bone mineral density (BMD). Several lines of evidence have suggested that the effects of weight on BMD may be mediated by hormonal factors, with the principal candidates being serum insulin, sex hormone, and adipocytokine. Adiponectin and its receptors are expressed in human osteoblasts. Recent evidences support the primitive roles of adiponectin in bone metabolism. Recombinant adiponectin induced receptor activator of NF-κB ligand (RANKL) and inhibited osteoprotegerin (OPG) mRNA expression in osteoblasts. Thus, the aim of this study was to investigate the relationship between serum adiponectin levels with circulating OPG/RANKL system in human being.
Subjects were eighty men aged 42~70 (mean age, 54.5 yr). Serum levels of adiponectin, OPG, and RANKL were measured by ELISA. Serum levels of total testosterone, estradiol, and biochemical markers of bone turnover were measured by standard methods. Bone mineral density (BMD) at lumbar spine and femoral neck were measured by dual energy x-ray absorptiometry.
Serum adiponectin levels were negatively correlated to weight, waist circumference, waist to hip ratio, and body mass index. Although serum adiponectin levels were not significantly correlated to fasting insulin and femoral neck BMD, but here was a weak trend in it. Serum adiponectin levels were not correlated with serum OPG and RANKL levels, either in the presence or absence of weight, fasting insulin, and femoral neck BMD.
We observed that the serum adiponectin levels were not associated with circulating OPG/RANKL system in middle-aged men. The biologic roles of adiponectin in bone metabolism still need further clarification.
Key Words: Adiponectin , Osteoprotegerin, Receptor activator of NF-κB ligand, Men


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