Journal of Bone Metabolism

"Osteoporosis"

Original Article

Effects of Normocalcemic Hyperparathyroidism on Structural Bone Compromise: A Prospective Observational Cohort Study: John Pietro, Amr Kaadan, Travis Cotton, Jon Olansen, Janine Molino, Roy Aaron; J Bone Metab 2026;33(2):152-160.
Published online May 31, 2026; DOI: https://doi.org/10.11005/jbm.25.997

Background
Normocalcemic hyperparathyroidism (NCHPTH) is characterized by elevated serum parathyroid hormone (PTH) levels in the presence of normal serum calcium levels, with the exclusion of secondary causes. NCHPTH remains underdiagnosed and is often associated with structural compromise of bone, namely osteoporosis and fragility fractures. The purpose of this study was to perform a prospective observational cohort study investigating NCHPTH in our Metabolic Bone Disease Service (MBDS).
Methods
Between January 2022 and June 2024, 815 patients were referred to our MBDS with an International Classification of Diseases, Tenth Revision diagnosis code of osteoporosis. Each patient underwent dual energy X-ray absorptiometry, and when indicated, assays for serum calcium, ionized calcium, 25-hydroxy-vitamin D (25[OH]D), and PTH.
Results
NCHPTH was identified in 25 patients (3%), approximating one patient per month. Skeletal involvement was frequent in the NCHPTH cohort, with 72% presenting with a history of fragility fractures. Mean PTH levels were 130.8 pg/mL, while serum calcium and 25(OH)D levels remained within the normal range. We compared the prevalence of NCHPTH in our MBDS to other referral populations, finding an increased prevalence in our service, likely due to the high frequency of skeletal compromise in this population.
Conclusions
These results indicate that NCHPTH is not merely a biochemical phenomenon but is rather frequently associated with skeletal pathology. We conclude that reliance on serum calcium alone likely leads to underdiagnosis of NCHPTH, whereas routine PTH testing can facilitate earlier detection, allow for preventative interventions, and enhance secondary fracture prevention efforts.

318 View
12 Download

Review Article

Polypharmacy and Bone Health in Patients with Type 2 Diabetes Mellitus: A Narrative Review: Israa O. Kashmoola, Shatha H. Mohammad, Mohammad H. Alsaaty; J Bone Metab 2026;33(2):127-140.
Published online May 31, 2026; DOI: https://doi.org/10.11005/jbm.25.975

Patients with type 2 diabetes mellitus (T2DM) commonly demonstrate reduced bone quality and elevated fracture risk rates despite having normal or elevated bone mineral density (BMD). Beyond the pathophysiological effect of diabetes, polypharmacy has emerged as a potential, yet underappreciated contributor of skeletal fragility. To explore this association, a thorough search of the literature was conducted using PubMed, Google Scholar, and Web of Science. and Scopus for articles published in English language until October 2025. Studies addressing diabetes, polypharmacy, bone health, and drug-related skeletal outcomes were identified and included. A divergent effect on bone health was evident in patients using antidiabetic agents, with thiazolidinediones, sulfonylurea and some insulin regimens increase fracture risk. Whereas metformin, incretinbased therapies and sodium-glucose co-transporter 2 inhibitors appear neutral or protective. Concerning non-antidiabetic medication used in T2DM, glucocorticoids, selective serotonin reuptake inhibitors, proton pump inhibitors and loop diuretics are among the drugs that worsen the bone architecture, causing increased fracture risk. On the other hand, statins, β-blockers, angiotensin converting enzyme inhibitors, thiazide diuretics and angiotensin receptor antagonists are bone protective. Such cumulative impact of polypharmacy involves drug-drug interactions, increased fall potential, and attenuation of antiresorptive therapy. Clinical interventions to prevent skeletal deterioration include periodic medications review, deprescribing of high-risk agents, calcium and vitamin D supplementation, and life-style modifications. Personalized and multidisciplinary strategies are essential to balance metabolic status with long-term skeletal preservation in patients with T2DM exposed to polypharmacy.

390 View
21 Download

Original Articles

Muscle Mass, Adiposity, and Bone Health in Surgical Care Setting: A Cross-Sectional Study: Ngo Thi Thu Thuy, Le Van Thieu, Tran Vuong The Vinh; J Bone Metab 2026;33(2):181-187.
Published online May 31, 2026; DOI: https://doi.org/10.11005/jbm.25.973

Background
Osteoporosis and sarcopenia are interrelated conditions that significantly affect surgical outcomes by impairing bone strength, mobility, and postoperative recovery. Understanding how body composition and metabolic factors influence bone mineral density (BMD) is essential for improving perioperative risk assessment and rehabilitation. This study aimed to evaluate the relationships between regional muscle mass, fat mass (FM), and circulating adipokines with BMD.
Methods
A cross-sectional study was conducted in 199 patients. Whole-body dual energy X-ray absorptiometry (DXA) was used to assess regional lean and FM and BMD at multiple skeletal sites. Serum leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Correlations were examined using Pearson’s coefficients, and stepwise multiple linear regression identified independent predictors of T-score.
Results
Trunk and gynoid muscle mass exhibited the strongest positive correlations with T-score (r=0.490 and r=0.475, both P<0.001). FM showed weaker associations, while adiponectin correlated inversely with BMD (r=-0.196, P=0.005). In multivariable analysis, trunk muscle mass (β=0.48, P<0.001), gynoid muscle mass (β=0.36, P=0.002), body mass index (β=0.18, P=0.031), and adiponectin (β=-0.22, P=0.008) remained independent predictors (adjusted R²=0.45).
Conclusions
Skeletal muscle, particularly in the trunk and hip regions, is the primary determinant of bone density, while adiponectin negatively influences BMD. Incorporating muscle mass assessment and metabolic optimization into perioperative care may enhance fixation stability and postoperative recovery.

323 View
14 Download

Bone Health in Breast Cancer Patients: Comparative Evaluation Using Dual Energy X-Ray Absorptiometry Scan and High-Resolution Peripheral Quantitative Computed Tomography: Sunaina Kumari, Sabaretnam Mayilvaganan, Sushil Gupta, Manisha Kakaji, Gyan Chand, Anjali Mishra, Gaurav Agarwal; J Bone Metab 2026;33(2):188-196.
Published online May 31, 2026; DOI: https://doi.org/10.11005/jbm.25.955

Background
Osteoporosis is highly prevalent among Indian women and is further exacerbated by cancer-directed therapies such as chemotherapy, hormonal therapy, and radiotherapy. Patients with breast cancer are particularly susceptible to bone loss. While dual energy X-ray absorptiometry (DXA) remains the gold standard, it does not assess bone microarchitecture. High-resolution peripheral quantitative computed tomography (HR-pQCT) may provide additional insights.
Methods
This cross-sectional pilot study was conducted between May and December 2024 at a tertiary care center and included 54 women with breast cancer without bone metastases. Demographic, clinical, and treatment data were recorded. All patients underwent DXA and HR-pQCT scans to assess bone density and microarchitecture. Statistical analysis included subgroup comparisons and concordance testing.
Results
Mean age was 55.8±11 years, and 65% were postmenopausal. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 positivity rates were 76%, 57%, and 28%, respectively. Osteoporosis was found in 38.2% and osteopenia in 61.8% by DXA. HR-pQCT revealed lower volumetric bone density (0.59±0.07 g/cm³) compared to DXA (0.84±0.16 g/cm³, P<0.01). Microarchitectural deficits were significant in postmenopausal women, chemotherapy recipients, and those on letrozole. Lin’s concordance correlation indicated poor agreement between HR-pQCT and DXA (<0.9).
Conclusions
HR-pQCT was superior to DXA in detecting microarchitectural deterioration in women with breast cancer. This pilot study emphasizes the need for larger prospective studies in Indian cohorts.

330 View
33 Download

Trends in Osteoporosis Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008–2011: The KSBMR KNHANES DXA Task Force Report: Namki Hong, Jeonghoon Ha, Jun-Il Yoo, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Yong-Chan Ha, Ki-Hyun Baek, Yumie Rhee, on behalf of the KNHANES DXA Joint Task Force of the Korean Society for Bone and Mineral Research (KSBMR); J Bone Metab 2026;33(2):141-151.
Published online April 24, 2026; DOI: https://doi.org/10.11005/jbm.26.003

Background
National estimates of osteoporosis prevalence in Korea has been based on dual energy X-ray absorptiometry (DXA) data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted between 2008 and 2011. In 2024, KNHANES resumed nationwide DXA testing, enabling updated prevalence estimates.
Methods
We compared the prevalence of osteoporosis (DXA T-score ≤-2.5 at lumbar spine, femoral neck, or total hip) and low bone mass (-1.0>T-score>-2.5 at any sites) among Korean adults aged ≥50 years between KNHANES 2008–2011 and 2024. Age-standardized prevalence estimates accounting for complex sampling were calculated. The Poisson regression model was used to assess prevalence ratios (PRs) between survey periods, with adjustment for anthropometric measures, lifestyle factors, and nutritional intake.
Results
The prevalence of osteoporosis declined between KNHANES 2008–2011 and 2024 from 20.8% to 14.6% (women, 32.6%–22.0%; men, 7.0%–4.9%; P<0.001 for all), with higher mean BMD at all skeletal sites in 2024. In women, the prevalence of low bone mass increased from 47.9% to 56.0%, while it declined from 47.4% to 33.3% in men. The proportions of physician-diagnosed osteoporosis (24.9%–34.5%) and treatment (11.1%–22.8%) increased over time, particularly among women. In men, PR of osteoporosis between periods was attenuated after adjustment for height and weight, whereas changes in anthropometry, lifestyle, and nutrition did not fully account for the decline in women.
Conclusions
From 2008 to 2011 and 2024, the prevalence of osteoporosis among Korean adults aged ≥50 years decreased, accompanied by improvements in the proportion of diagnosis and treatment.

738 View
56 Download

Review Article

Fatty Acid-Sensing G Protein-Coupled Receptors in Skeletal Metabolism: Hyun-Ju Kim, Dong-Kyo Lee, Xiangguo Che, Sihoon Lee, Je-Yong Choi; J Bone Metab 2026;33(1):1-17.
Published online February 28, 2026; DOI: https://doi.org/10.11005/jbm.25.937

G protein-coupled receptors (GPCRs), commonly known as seven-transmembrane domain receptors, represent one of the largest and most functionally diverse families of membrane receptors. These receptors mediate cellular responses to external signals, thereby influencing various physiological processes. Recent studies have increasingly highlighted the importance of GPCRs in skeletal health, particularly in regulating bone metabolism and the pathogenesis of bone diseases, such as osteoporosis and osteoarthritis. Among GPCRs, a specific subset that responds to fatty acids, including GPR40, GPR120, GPR41, GPR43, GPR84, and GPR119, has received significant attention for its role in skeletal homeostasis. Acting as lipid sensors, these receptors detect changes in fatty acid availability and transduce signals that modulate the differentiation, function, and survival of key bone cell populations, including osteoclasts, osteoblasts, and chondrocytes. This review provides a comprehensive overview of the current understanding of fatty acid-sensing GPCRs in skeletal metabolism, highlighting their potential as novel therapeutic targets for metabolic bone diseases.

Citations

Citations to this article as recorded by

1. G protein-coupled receptor signaling in osteogenic bone mesenchymal stem/stromal cells
Trevor J. Wolfe, Samantha R. Weaver
Frontiers in Cell and Developmental Biology.2026;[Epub] CrossRef

1,127 View
42 Download
Crossref

Original Articles

Trabecular Bone Score and Mortality Risk in a Population-Based Cohort of Older Adults: Carlos H. Orces; J Bone Metab 2026;33(1):40-49.
Published online February 28, 2026; DOI: https://doi.org/10.11005/jbm.25.917

Background
Osteoporosis is consistently reported to increase mortality risk in older adults. Whether trabecular bone score (TBS), an indirect index of trabecular microarchitecture, increases mortality risk has not been widely studied.
Methods
Participants aged 60 years and older in the National Health and Nutritional Examination Survey 2005 to 2008 with complete data on TBS lumbar vertebrae were linked to the public-use mortality files through December 31st, 2019. The X-tile software (version 3.6.1; Yale University) was used to obtain the overall and sex-specific optimal TBS cut-off values associated with all-cause mortality (log-rank test P<0.0001). Then, TBS was grouped into low (≤1.24), medium (1.25-1.39), and high (≥1.40) categories.
Results
A total of 2,641 participants with a mean age of 69.8 (standard error 0.2) years comprised the study sample. Of those, 1,109 older adults died after a median follow-up of 140 months. Overall, survival probability progressively decreased across TBS categories, which was accentuated in subjects with low TBS. Cox regression analysis demonstrated that participants with low TBS had 47% (hazard ratio [HR], 1.47; 95% confidence interval [CI], 1.10-1.96) greater all-cause mortality risk than their counterparts with high TBS, even after accounting for potential confounders including bone mineral density. Notably, older adults with low TBS had 2-fold higher risk of cancer-related mortality than those with high TBS (HR, 2.07; 95% CI, 1.17-3.67).
Conclusions
Low TBS was significantly associated with greater all-cause and cancer-related mortality in older adults.

685 View
17 Download

Mapping a Decade of Osteoporosis and Fracture Research: A Bibliometric Analysis (2015–2025): Oluwafemi Samson Balogun, Sunday Adewale Olaleye, Margaret Adebola Balogun, Esther Olubunmi Olaleye, Muhammad Zeshan Arshad, Keijo Haataja, Pekka Toivanen; J Bone Metab 2026;33(1):94-107.
Published online February 28, 2026; DOI: https://doi.org/10.11005/jbm.25.903

Background
Osteoporosis is a major global health concern, affecting over 200 million individuals worldwide. Although numerous clinical and experimental studies exist, comprehensive analyses integrating fracture-related and drug-specific research remain limited. Examining global research trends can highlight evolving themes, key contributors, and areas requiring scientific attention.
Methods
We performed a bibliometric analysis of literature on osteoporosis and fractures, including drug-specific terms (denosumab, romosozumab, teriparatide), published between 2015 and 2025 in the Scopus Core Collection. Data were assessed for publication trends, authorship, institutional output, international collaboration, and thematic evolution using Bibliometrix-Biblioshiny in RStudio. Network analyses included co-authorship and keyword co-occurrence mapping for both quantitative and qualitative insights.
Results
From 4,450 articles, annual output showed steady growth, peaking between 2021 and 2024. The United States, Japan, and China led in publication volume and citation impact, while Osteoporosis International was the most productive journal. Citation averages declined recently due to lag in newer publications. Thematic mapping identified pharmacological therapies such as denosumab and teriparatide as core themes, while “fracture prevention” and “DXA-based assessment” emerged as active research fronts. International collaboration decreased after 2020, particularly affecting contributions from low- and middle-income countries.
Conclusions
Global osteoporosis research demonstrates sustained productivity but declining collaboration and limited thematic diversification. Strengthening international networks, supporting underrepresented regions, and expanding focus to preventive and non-pharmacological strategies are essential for equitable and impactful progress.

833 View
42 Download

Bisphosphonate Use and Reduced All-Cause Mortality in Korean Women Older than 50 Years: A Nationwide Sample Cohort Study: Soon Young Park, Jisoo Lee, Youjin Lee, Jung-Wee Park, Young-Kyun Lee; J Bone Metab 2025;32(4):323-330.
Published online November 30, 2025; DOI: https://doi.org/10.11005/jbm.25.933

Background
The survival impact of bisphosphonates (BPs) remains uncertain, particularly in East Asian populations, where new-user analyses have been limited.
Methods
This was a retrospective, new-user cohort study using the Korean National Health Insurance Service–National Sample Cohort (2002–2011). We identified new users of BPs (N=41,854), and a 1:1 age-matched control group (N=41,854) among women aged ≥ 50 years. Participants were followed for all-cause mortality for up to 10 years. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs), adjusting for age and the Charlson Comorbidity Index.
Results
A total of 83,708 women were included. Compared with the control group, the risk of all-cause mortality was lower in BP group. BP users showed adjusted HR of 0.47 (95% confidence interval, 0.44–0.49; P<0.001) compared to controls.
Conclusions
In this large, nationwide Korean cohort, initiating BPs was associated with a reduced risk of all-cause mortality in women aged 50 and older. These findings suggest that BPs may have survival benefits beyond fracture prevention.

Citations

Citations to this article as recorded by

1. Osteoporosis in the long-lived: focus on safety and quality of life
N. V. Brailova, E. N. Dudinskaya, M. A. Morozova, T. V. Sopetik, O. A. Dogotar
Russian Journal of Geriatric Medicine.2026; (2): 185. CrossRef
2. Risk of Cardiovascular Events in Patients with Osteoporosis on Romosozumab Treatment Compared with Denosumab: A Multicenter Observational Cohort Study
Seong Hee Ahn, Dachung Boo, Kyoung Jin Kim, Jimi Choi, Hyemin Yoon, Chai Young Jung, Seng Chan You, Ji Seon Oh, Namki Hong
Endocrinology and Metabolism.2026; 41(3): 442. CrossRef

1,308 View
44 Download
Crossref

Review Article

Endocrine Regulation of Osteoporosis: Insights from the Brain-Bone Axis Theory: Xin Chen, Jialing Wang, Tingting Deng, Qing Ni, Fanjie Liu; J Bone Metab 2025;32(4):247-262.
Published online November 30, 2025; DOI: https://doi.org/10.11005/jbm.25.887

Osteoporosis (OP) is a systemic skeletal disease characterized by reduced bone mass and increased risk of fractures, with limitations in traditional treatment methods. The “brainbone axis” theory has revealed a bidirectional regulatory network between the central nervous system and the skeletal system, providing new insights into the mechanisms and treatment of OP. This review summarizes the bidirectional regulatory mechanisms of the “brain-bone axis”, including descending pathways (such as the regulation of bone metabolism by the sympathetic nervous system, parasympathetic nervous system, and hypothalamic nuclei) and ascending feedback (such as bone-derived factors influencing central nervous system function through the blood-brain barrier), and explores the synergistic roles of endocrine systems (such as the thyroid axis and gonadal axis) within this network. Additionally, the article summarizes multi-modal treatment strategies based on the “brain-bone axis” theory, offering new insights for the precise prevention and treatment of OP. Future research should further integrate basic and clinical studies to advance the paradigm shift of OP from a localized bone disorder to a systemic disease.

Citations

Citations to this article as recorded by

1. Poor Bone Health Associated with Reduced Cerebral Perfusion and Brain Volume in Older Adults
Tiffany Y. So, James F. Griffith, Jill Abrigo, Lin Shi, David K. W. Yeung, Jason Leung, Timothy Kwok, Vincent C. T. Mok
Diagnostics.2026; 16(4): 529. CrossRef
2. A bibliometric analysis of the associations between Osteoporosis and Central Nervous System
Guangbin Yu, YingYing Gao, Hongyuan Song, Xiong Chen, Sitong Kuang, Conghan Su, le Li, Manguang Liang, Guocai Chen
Experimental Gerontology.2026; 220: 113175. CrossRef
3. The recent progression of extracellular vesicles application in osteoporosis
Rui Liu, Wenyu Li, Junzheng Yang
Frontiers in Pharmacology.2026;[Epub] CrossRef

2,057 View
81 Download
Crossref

Original Articles

Awareness, Knowledge, and Health Beliefs Regarding Osteoporosis among Hypothyroid Patients in Turkey: An Observational Study: Feyza Nur Yücel, Mustafa Hüseyin Temel, Muhammed Görgel, Yeliz Bahar-Özdemir, Emre Ata, Eylem Çağıltay; J Bone Metab 2025;32(3):200-211.
Published online August 31, 2025; DOI: https://doi.org/10.11005/jbm.25.855

Background
Hypothyroidism is the most common thyroid dysfunction, and current evidence suggests that it increases the risk of osteoporosis in these patients. Assessing the level of osteoporosis awareness and understanding among hypothyroid patients is an important requirement for implementing preventive interventions to maintain bone health.
Methods
Thyroid-stimulating hormone, thyroxine, and 25-hydroxy-vitamin D levels were recorded along with the patients’ demographics. Osteoporosis awareness was assessed with the osteoporosis awareness scale (OAS), and knowledge level was assessed with the revised osteoporosis knowledge test (R-OKT). Health beliefs related to osteoporosis were evaluated using the osteoporosis health belief scale (OHBS).
Results
The median (interquartile range) values for OAS and R-OKT of 348 patients were calculated as 66.0 (32.0) and 9.0 (5.0), respectively. Female patients had higher OAS scores (P<0.001), OHBS benefits of exercise (P=0.002), and calcium intake (P<0.001) subscores compared to males. The distribution of OAS, R-OKT, and OHBS total and susceptibility scores differed significantly across education categories (P<0.001). The linear regression model revealed significant predictors of OAS score variation, including gender (β=-0.27, P<0.001), education (β=0.09, P=0.045), and osteoporosis knowledge (β=0.49, P<0.001).
Conclusions
Patients with hypothyroidism, particularly males and those with lower educational attainment, lack adequate knowledge and awareness regarding osteoporosis. To better comprehend and manage osteoporosis, targeted educational initiatives are required for this vulnerable group.

2,207 View
38 Download

High Radiological Worsening in Patients with Vertebral Fragility Fractures and the Associated Factors: Mauricio Soto-Subiabre, Victor Mayoral, Lidia Valencia-Muntalà, Carlos González, Carmen Gómez-Vaquero; J Bone Metab 2025;32(2):143-154.
Published online May 31, 2025; DOI: https://doi.org/10.11005/jbm.25.835

Background
To investigate the contribution of radiological characteristics of baseline fragility vertebral fractures (FVF) and clinical characteristics to the development of radiological worsening (RW).
Methods
Patients were recruited between 2015 and 2018. The primary outcome was the identification of RW in a radiological second image, defined as the progression of prevalent FVF, new FVF, or both. Data on fracture risk fractures, bone mineral density, analgesia requirements, and antiosteoporosis treatment were recorded. The radiological features of baseline FVF included fracture number, location(s), severity grade (Genant method), kyphosis angle, and spine index deformity.
Results
A total of 223 patients with at least one follow-up radiological evaluation were included. Another 199 patients had no radiological follow-up. Of those with follow-up, 69% presented RW, accounting for 36.5% of the total cohort (422 patients). The incidence rate of RW was 73.8/1,000 patient-years. Among those with RW, 61% showed progression of FVF, 27% developed new FVF, and 12% had both. The multivariate analysis demonstrated that multiple FVF and worse grades of FVF at baseline were variables significantly associated with RW. Baseline characteristics of FVF that increased the risk of RW by progression of FVF was grade 1 (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.47-7.02) and grade 2 (OR, 1.97; 95% CI, 1.05-3.68) and by new FVF was grade 3 (OR, 3.19; 95% CI, 1.39-7.33) FVF.
Conclusions
Approximately one-third of patients with FVF experienced RW, with progression of FVF being the most common event. A higher number of FVF and a greater severity at baseline are associated with RW.

1,842 View
58 Download

Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling: Lucas R. Brun, Muriel M. Henríquez, Luis A. Ramírez Stieben, Mariana Cusumano, Jorge Homero Wilches-Visbal, Fernando Daniel Saraví, María Lorena Brance; J Bone Metab 2025;32(2):123-132.
Published online May 31, 2025; DOI: https://doi.org/10.11005/jbm.24.827

Background
Yerba mate (YM) drinking is associated with higher lumbar spine and femoral neck bone mineral density (BMD) in postmenopausal women. We analyzed its effect on total hip BMD and reported the contribution of the trabecular and cortical components to this effect.
Methods
A control group of 147 non-drinkers was compared to 153 YM drinkers. Left hip BMD was measured using dual energy X-ray absorptiometry (DXA), and three-dimensional (3D)-Shaper software was used to estimate integral volumetric BMD (vBMD), cortical surface BMD (sBMD), and trabecular vBMD through 3D modeling.
Results
No significant difference was found between groups in either age (p=0.746) or body mass index (BMI; p=0.329). The YM group had significantly higher total hip BMD, integral vBMD, cortical sBMD, and trabecular BMD (all p<0.0001). The frequency of DXA-based osteoporosis diagnosis was lower in YM drinkers (3.3% vs. 10.9%; odds ratio [OR], 0.276). The rate of low-impact fractures was significantly reduced in YM drinkers (5.9% vs. 12.9%; OR, 2.197). Linear regression analyses revealed that cortical and trabecular parameters correlated positively with BMI and negatively with age in both groups. The slope of the lines did not differ between groups, but the elevation was uniformly higher in the YM group (p=0.0004 to p<0.0001).
Conclusions
Our study provides novel insights into YM consumption and bone health in postmenopausal women. We confirm its positive association with BMD and demonstrate, for the first time, that both cortical and trabecular compartments contribute to this effect. Our findings also suggest a potential protective role of YM against osteoporosis and fragility fractures.

Citations

Citations to this article as recorded by

1. Effect of Caffeine on the Skeletal System—A Review of Experimental Studies
Paulina Stańczak, Wiktor Krzysztofik, Wiktoria Rudolf, Kacper Grzywnowicz, Joanna Folwarczna
Nutrients.2026; 18(13): 2089. CrossRef
2. Yerba Mate (Ilex paraguariensis) and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence
Manuela Cassotta, Qingwei Cao, Haixia Hu, Carlos Rabeiro Martinez, Luis Alonso Dzul Lopez, Santos Gracia Villar, Maurizio Battino, Francesca Giampieri
Nutrients.2025; 17(24): 3853. CrossRef

2,941 View
93 Download
Crossref

The Influence of Fish Bone Powders on the Bone Density in Corticosteroid-Induced Osteoporosis Rats: Annis Catur Adi, Wizara Salisa, Sri Fatmawati, Emyr Reisha Isaura, Heni Rachmawati; J Bone Metab 2025;32(2):103-113.
Published online April 18, 2025; DOI: https://doi.org/10.11005/jbm.24.819

Background
The adequacy of calcium from food consumption is difficult to meet because of its low absorption rate, causing an increased risk of osteoporosis. One of the ways to increase calcium absorption is to increase its solubility by decreasing its particle size. This study aimed to observe the influence of particle size and mineral composition of various fish bone powders on bone density enhancement after oral administration to corticosteroid-induced osteoporosis rats.
Methods
The test stages carried out include manufacturing fish bone flour and nanonization, characterization (particle size and nutritional content), conducting experimental tests on rats using blood serum samples, and observing bone growth and density. The types of fish studied were catfish, snakehead fish, mackerel, and snapper.
Results
Nanonization processing has been proven to reduce the size of flour particles, increase its nutritional and mineral content, and maximize the calcium absorption rate in rats. The results of the test on experimental animals induced osteoporosis showed that rats given the intervention of milling snapper fish bone meal produced the best outcomes in body length, body mass index, calcium, magnesium, and serum phosphorus (P<0.05). While in bone parameters, catfish bone meal was the most optimal in encouraging bone density percentage.
Conclusions
In conclusion, to increase serum minerals and bone density optimally, in addition to reducing particle size, the ratio of mineral content also needs to be considered.

Citations

Citations to this article as recorded by

1. Integration of fishbone deep processing technology with animal experiments on inventive calcium supplements for aquatic circular economy
Erh Ruei Wang, Chih Hsiung Huang, Kuang Ting Huang, Wen Ling Shih, Tsung Ming Yeh
Applied Food Research.2025; 5(2): 101334. CrossRef

3,169 View
77 Download
Crossref

Twenty-Year Trends in Osteoporosis Treatment and Post-Fracture Care in South Korea: A Nationwide Study: Kyoung Jin Kim, Kyoung Min Kim, Young-Kyun Lee, Jihye Kim, Hoyeon Jang, Jaiyong Kim, Ha Young Kim; J Bone Metab 2025;32(1):57-66.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.829

Background
Osteoporosis is a significant public health issue in aging populations. Despite advances in pharmacotherapy, underdiagnosis and undertreatment remain prevalent even in patients with recent fractures. This study examined 20-year trends (2002– 2022) in anti-osteoporotic medication (AOM) usage in South Korea.
Methods
Data from the Korean National Health Information Database were retrospectively analyzed. The study included individuals aged ≥50 years and analyzed prescription trends, medication adherence, measured by the medication possession ratio (MPR), and treatment initiation rates post-fracture. The AOMs examined included bisphosphonates, selective estrogen receptor modulators, denosumab (DMAB), teriparatide (TPTD), and romosozumab (ROMO).
Results
Over two decades, AOM use has shifted significantly from oral to injectable formulations, with injectables surpassing oral medications in 2020; from 397,440 prescriptions in 2016 to 1,162,779 in 2022. Prescriptions for DMAB surged following its approval as a first-line therapy in 2019, increasing 2.65 times from 217,606 in 2019 to 575,595 in 2022. The MPR improved from 35.4% in 2003 to 73.2% in 2021, with females demonstrating higher adherence than males. Post-fracture treatment rates increased from 31.1% in 2006 to 39.9% in 2021 but remained below 50%. Vertebral fractures had the highest treatment initiation rates, while anabolic agents, such as TPTD and ROMO were underprescribed despite their efficacy.
Conclusions
This 20-year analysis highlights significant progress in osteoporosis management in South Korea, including a shift towards injectable therapies and improved adherence. However, the persistent undertreatment of high-risk patients underscores the requirement for enhanced access to anabolic agents, clinician education, and policy reforms to optimize post-fracture care.

Citations

Citations to this article as recorded by

1. Multidisciplinary management of acute osteoporotic vertebral fracture: results of a national Delphi consensus
Luis Alvarez-Galovich, Estanislao Arana, Juan Francisco Blanco Blanco, José Manuel Cancio Trujillo, Santos Castañeda, Carolina de Miguel Benadiba, Alfonso González Ramírez, Guillermo Martínez Díaz-Guerra
Archives of Osteoporosis.2026;[Epub] CrossRef
2. Nationwide Big Data Studies of Endocrine Diseases Using the Korean National Health Information Database: Research Trends and Standardization of Operational Definitions
Sun Wook Cho, Jung Hee Kim, Kyoung Jin Kim, Beom-Jun Kim, Mee Kyoung Kim, Eun Jung Rhee
Endocrinology and Metabolism.2026; 41(1): 86. CrossRef
3. Comparative Radiologic Outcomes of Romosozumab and Teriparatide in Osteoporotic Vertebral Fractures
Jun-Seok Lee, Geon-U Kim, Ho-Young Jung, Young-Hoon Kim, Sang-Il Kim, Sangjun Park, Young-Yul Kim, Hyung-Youl Park
Journal of Clinical Medicine.2026; 15(6): 2349. CrossRef
4. Age-specific loss of life expectancy after hip fracture in Asian adults: A nationwide population-based cohort study
Kyoung Jin Kim, Su Jin Kwon, Seunghyun Lee, Seong Hee Ahn, So Young Park, Ha-Young Kim, Kyoung Min Kim
Bone.2026; 208: 117896. CrossRef
5. Impact of In-Hospital Osteoporosis Treatment on Post-discharge Medication Continuity in Osteoporotic Fracture Patients: Implications for Care Continuity
Seung Hoon Kim, Seoyeong Choi, Yonghan Cha, Eunjeong Choi, Suk-Yong Jang
Clinics in Orthopedic Surgery.2026; 18(3): 571. CrossRef
6. Trends in anti-osteoporosis pharmacotherapy and pharmacological initiation for secondary fracture prevention in Japan, 2017–2023
Masaki Hatano, Akira Okada, Yuya Kimura, Hisatoshi Ishikura, Takeyuki Tanaka, Taku Saito, Sakae Tanaka, Hideo Yasunaga
Bone.2026; 211: 117979. CrossRef
7. National trends in osteoporosis in the general older population and postmenopausal women, to the COVID-19 pandemic by related factors, 2001-2021: a nationwide study in South Korea
Hyejun Kim, Jaeyu Park, Jiseung Kang
Life Cycle.2025;[Epub] CrossRef
8. Hysteroscopy in Asymptomatic Postmenopausal Women With Thickened Endometrium: Analyzing Clinical Characteristics and Pathology With an Emphasis on SERM History
Ze Liang, Xiangyu Gu, Yifan Dong, Wenbo Li, Changshuai Lv, Ling Li, Jiali Tong
Journal of Minimally Invasive Gynecology.2025; 32(12): 1074. CrossRef
9. From Bone Health to Lifespan: Pleiotropic Effects of Antiresorptive Agents
Kyoung Jin Kim
Endocrinology and Metabolism.2025; 40(4): 508. CrossRef
10. Knowledge, attitudes, and practices toward osteoporosis: a questionnaire survey
Min Xue, Jiesheng Xia, Xiaohui You, Xun Zhu, Li Zheng, Qi Wei, Miao Zheng, Jialong Tao, Yuntian Shen, Qi Zhou, Jiani Qian, Minjie Chu, Youjia Xu
Frontiers in Public Health.2025;[Epub] CrossRef
11. Risk of Pelvic Insufficiency Fractures in Cervical Cancer Survivors: Using the National Claim Database
Ki-Tae Park, Jung-Wee Park, Ye Jin Jeon, Jean Kyung Bak, Bit-Na Yoo, Youn Kyung Chung, Byung-Ho Yoon, Young-Kyun Lee
Journal of Korean Medical Science.2025;[Epub] CrossRef
12. Cost-utility analysis of coordinator services (FLS) in patients with femur fractures
Gyeong-Min Lee, Han-Sol Jang, Minsu Choi, Yonghan Cha, Seung Hoon Kim, Minah Park, Kwang-Soo Lee, Jae-Hyun Kim
Archives of Osteoporosis.2025;[Epub] CrossRef
13. Trends of incidence and 1-year mortality of vertebral fractures in Korea using nationwide claims data
Young-Kyun Lee, Jung-Wee Park, Tae-Young Kim, Jihye Kim, Hoyeon Jang, Jaiyong Kim, Yong-Chan Ha
Archives of Osteoporosis.2025;[Epub] CrossRef

4,218 View
133 Download
Crossref

Treatment Goals for Prevention of Vertebral Fractures in Patients with Rheumatoid Arthritis: Takeshi Mochizuki, Mari Ando, Koichiro Yano, Ryo Hiroshima, Katsunori Ikari, Ken Okazaki; J Bone Metab 2025;32(1):49-56.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.811

Background
Patients with rheumatoid arthritis (RA) are at an increased risk of osteoporosis and vertebral fractures. This study aimed to investigate factors associated with vertebral fractures and treatment goals to prevent new vertebral fractures in patients with RA.
Methods
The database used in this study included outpatient data of RA patients at the authors’ hospital of RA patients taken from 2018 to 2022. The patients underwent annual imaging evaluations to assess parameters, including bone mineral density of the lumbar spine (LS; L2-4), total hip, and femoral neck, as well as vertebral fractures. Vertebral fractures were evaluated using radiographic images of the T8 to L5 vertebrae.
Results
The prevalence rates of new vertebral fractures in 2018–2019, 2019–2020, 2020– 2021, and 2021–2022 were 2.0%, 1.3%, 2.3%, and 2.0%, respectively. The presence of existing vertebral fractures was associated with new vertebral fractures (p=0.003; odds ratio, 0.241; 95% confidence interval, 0.093–0.624). The cut-off T-score values for the LS for new vertebral fractures in patients with or without pre-existing vertebral fractures were -0.7 (sensitivity, 40.9%; specificity, 100%) and -1.4 (sensitivity, 69.0%; specificity, 62.5%), respectively.
Conclusions
The presence of pre-existing vertebral fractures is an independent factor associated with new vertebral fractures. It is important to tailor treatment goals based on the presence or absence of vertebral fractures to effectively prevent new fractures.

2,590 View
54 Download

Review Article

Efficacy of Bisphosphonate in Patients with Neurofibromatosis Type 1: Arzu Jalilova, Alessandra Cocca; J Bone Metab 2025;32(1):1-10.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.809

This review aims to synthesize current knowledge regarding the use of bisphosphonates (BPs) in the treatment of bone complications in patients with neurofibromatosis type 1 (NF1). NF1 is a genetic disorder marked by multiple benign tumors of the nervous system and various skeletal abnormalities, such as osteoporosis and an increased risk of fractures. BPs are drugs that inhibit bone resorption, commonly used to treat osteoporosis and other bone diseases. The review identified multiple studies examining the effects of BP therapy in NF1 patients. Most studies reported improvements in bone mineral density and reduced fracture occurrence. The most commonly reported side effects were mild gastrointestinal symptoms and transient musculoskeletal pain. However, the evidence is limited by the small number of studies and the heterogeneity of patient populations and treatment protocols. In conclusion, BPs show improvements in managing NF1 complications such as osteoporosis and a reduction of fracture risk in NF1 patients. While the existing studies suggest positive outcomes, there is a need for more rigorous, large-scale studies to establish standardized treatment protocols and long-term safety profiles. Healthcare providers should consider BP therapy as a potential option for NF1 patients with significant bone complications, while also monitoring for possible adverse effects.

Citations

Citations to this article as recorded by

1. Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling
Jung Ha Kim, Semun Seong, Kabsun Kim, Inyoung Kim, Jeong-Tae Koh, Nacksung Kim
Molecules and Cells.2026; 49(5): 100342. CrossRef

3,102 View
80 Download
Crossref

Original Articles

Incidence of Hypercalcemia and Vertebral Fractures Following Denosumab Withdrawal in Lung Cancer Patients: A Longitudinal Cohort Study: Marta Villanova, Sharon H. Chou, Le Min; J Bone Metab 2025;32(1):38-48.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.803

Background
Bone-target agents (BTAs), including denosumab (DMAb), are one of the bone metastasis treatments that should continue indefinitely. However, BTAs may be interrupted in some cases. In osteoporosis, DMAb withdrawal causes a rebound effect characterized by an increased bone turnover with spine fractures and hypercalcemia; evidence of the DMAb withdrawal effect in oncology is lacking.
Methods
This study aimed to identify the DMAb withdrawal effect amongst lung cancer patients treated with DMAb for bone metastases between January 2020 and December 2021. Patients who discontinued DMAb were included. Encounter notes, radiological and laboratory findings were comprehensively reviewed.
Results
Thirty patients were included with a median follow-up of 21 months (interquartile range [IQR], 10-30) after DMAb discontinuation. Bisphosphonates were administered before starting DMAb in 7 patients (23.3%) and after DMAb withdrawal in 4 cases (13.3%). Three cases of DMAb withdrawal-related hypercalcemia and 3 cases of spine fractures following DMAb cessation were identified in 5 patients (16.7%), all of them were females and the median age was 65 years old (IQR, 65-70). No statistical difference in DMAb duration or number of injections was found in patients developing DMAb withdrawal-related spine fractures or hypercalcemia compared with others (binary logistic regression, p=0.688 and p=0.938, respectively).
Conclusions
Patients with bony-metastatic lung cancer, especially post-menopausal women, are at risk of fractures and calcium abnormalities after DMAb discontinuation, suggesting that DMAb withdrawal effect may also be present in the oncological setting. A close follow-up and careful monitoring during and after discontinuation of DMAb is necessary.

Citations

Citations to this article as recorded by

1. Atypical femoral fracture and jaw osteonecrosis under high doses of denosumab, healed with the aid of low dose of denosumab: a case report
Hanene Lassoued, Olivier Lamy, Cyril Francioli, Elena Gonzalez Rodriguez
Frontiers in Endocrinology.2026;[Epub] CrossRef
2. Hypercalcemia of Malignancy and Medication-Related Osteonecrosis of the Jaw Following Denosumab Discontinuation in Metastatic Breast Cancer: A Case Report
Omar Shazley, Christina Orr
Cureus.2025;[Epub] CrossRef
3. Transient increase in skeletal-related events after discontinuation of high-dose denosumab in cancer patients
Nokitaka Setsu, Nobuhiko Yokoyama, Taito Esaki, Masafumi Yamaguchi, Eriko Tokunaga, Takahito Negishi
Journal of Bone Oncology.2025; 55: 100717. CrossRef
4. Parathyroid Hormone (1–34) Signaling for Bone Health in Breast Cancer Survivorship and Metastasis
Shinyoung Oh, Ha Ram Oh, Chen Shen, Young Ran Park, Ji Hyun Park
Journal of Cellular Physiology.2025;[Epub] CrossRef

3,478 View
69 Download
Crossref

Generate Quantitative Computed Tomography-Equivalent Computed Tomography Image Interpretation Reports in Patients with Spinal Deformities: Hyunbin Kim, Hyeon Su Kim, Shinjune Kim, Jun-Il Yoo; J Bone Metab 2025;32(1):31-37.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.801

Background
Quantitative computed tomography (QCT) is essential for assessing osteoporosis and monitoring spinal deformities. “Clari-QCT,” a software that uses artificial intelligence to analyze conventional computed tomography (CT) scans and produce QCTequivalent reports. This study aims to evaluate the effectiveness of Clari-QCT by comparing its results with traditional QCT, with the goal of validating new diagnostic tools for spinal deformities.
Methods
The study analyzed dual energy X-ray absorptiometry, CT, and QCT data from 18 patients at Inha University Hospital. Clari-QCT software was evaluated for its ability to generate QCT-equivalent reports from CT images. The software processes abdomen CT images, calculates bone density in designated slices, and provides bone mineral density (BMD), T-score, and Z-score values. Patients were classified into normal, mild, and severe spinal deformity groups. Intraclass correlation coefficient (ICC) analysis was used to measure the agreement between actual and predicted BMD values.
Results
The study included participants with an average age of 64 and a mean body mass index of 24.88. The average BMD was 94.7 g/cm³ by QCT and 122.5 g/cm³ by Clari- QCT, with individual differences ranging from 4.9 to 61.8. T-score discrepancies ranged from 0.16 to 6.86. ICC analysis showed moderate to high agreement between methods, with ICC1 values of 0.597, ICC2 of 0.64, ICC3 of 0.81, and ICC1k, ICC2k, ICC3k values ranging from 0.748 to 0.895.
Conclusions
Clari-QCT demonstrates good agreement with actual QCT measurements in normal and severe spinal deformity groups but shows reduced accuracy in patients with mild deformities. If the limitations are addressed, it could become a useful tool for monitoring bone health in patients with spinal deformities.

2,255 View
36 Download

Pharmacogenetics of Response to Bisphosphonate Treatment in Postmenopausal Osteoporosis: A Prospective Study: Sirin Akbulut Ayturk, Ozden Ozyemisci Taskiran, Ebru Koseoglu Tohma, Aylin Sepici Dincel, Nesrin Demirsoy, Vesile Sepici; J Bone Metab 2025;32(1):21-30.
Published online February 28, 2025; DOI: https://doi.org/10.11005/jbm.24.787

Background
This study aims to investigate the effect of genetic polymorphisms of vitamin D receptor (VDR), estrogen receptor 1 (ER1), and Col1a1 on the response to bisphosphonate (BP) therapy in women with postmenopausal osteoporosis (OP).
Methods
Twenty-one women with postmenopausal OP who received alendronate, ibandronate, or zoledronic acid for one year were enrolled in this study. Bone mineral density (BMD) at the lumbar spine and femoral neck were assessed by dual energy X-ray absorptiometry at baseline and after 12 months. Serum osteocalcin levels were measured at baseline and after 12 months. Polymorphic sites of the genes encoding ER1, VDR and Col1a1 proteins were amplified by polymerase chain reaction and examined using restriction fragment length polymorphism. Response to BP treatment and change in osteocalcin levels were compared among women with different gene polymorphisms.
Results
Ratio of responders to treatment regarding improvements in the BMD of lumbar spine and femoral neck was adequate in 76% and 62%, respectively. There was no significant difference in treatment response regarding BMD in either region or change in serum osteocalcin levels among different gene polymorphisms.
Conclusions
These findings did not support the potential role of VDR BsmI, Col1a1 Sp1, ER1 PvuII, or XbaI polymorphisms in predicting the response to BP therapy in women with postmenopausal OP. Further investigation with larger prospective studies is required.

2,493 View
71 Download

Discriminatory Accuracy of Fracture Risk Assessment Tool in Asian Populations: A Systematic Review and Meta-Analysis: Dheeraj Jha, Manju Chandran, Namki Hong, Yumie Rhee, Seungjin Baek, Stephen J. Ferguson, Benedikt Helgason, Anitha D. Praveen; J Bone Metab 2024;31(4):296-315.
Published online November 30, 2024; DOI: https://doi.org/10.11005/jbm.24.781

Background
This review explores the discriminative ability of fracture risk assessment tool (FRAX) in major osteoporotic fracture (MOF) and hip fracture (HF) risk prediction and the densitometric diagnosis of osteoporosis in Asian populations.
Methods
We systematically searched the EMBASE, Cochrane, and PubMed databases from the earliest indexing date to January 2024. Studies were included if FRAX was used to identify future osteoporotic fractures or a densitometric diagnosis of osteoporosis in an Asian population and reported the area under the curve (AUC) values. Meta-analyses were conducted after quality assessment for AUC with 95% confidence intervals across the following categories: standard FRAX without/with bone mineral density (BMD), adjusted FRAX, and BMD alone for fracture prediction, as well as standard FRAX for densitometric diagnosis of osteoporosis.
Results
A total of 42 studies were included. The AUC values for predicting fracture risk using FRAX-MOF with BMD (0.73 [0.70–0.77]) was highest compared to FRAX-MOF without BMD (0.72 [0.66–0.77]), and adjusted FRAX-MOF (0.71 [0.65–0.77]). The AUC values for predicting fracture risk using FRAX-HF with BMD (0.77 [0.71–0.83]) was highest compared to FRAX-HF without BMD (0.72 [0.65–0.80]), and adjusted FRAX-HF (0.75 [0.63–0.86]). The AUC values for BMD alone (0.68 [0.62–0.73]) was lowest for fracture prediction. The AUC values for identifying a densitometric diagnosis of osteoporosis was 0.77 [0.70–0.84] and 0.76 [0.67-0.86] using FRAX-MOF and FRAX-HF, respectively.
Conclusions
FRAX with BMD tends to perform more reliably in predicting HF compared to MOF in Asia. However, its accuracy in predicting fracture risk in Asian populations can be improved through region-specific, long-term epidemiological data.

Citations

Citations to this article as recorded by

1. DXA-derived biofidelic finite element models for quantifying the efficacy of hip protectors
Dheeraj Jha, Yijun Zhou, Anitha D Praveen, Ellie S Galliker, Preeti Gupta, Ecosse L Lamoureux, Namki Hong, Yumie Rhee, Halldór Pálsson, Stephen J Ferguson, Benedikt Helgason
JBMR Plus.2026;[Epub] CrossRef
2. Health outcomes and care needs after osteoporotic fractures in rural Chinese older adults: policy implications
Qian Zhu, Caixia Ran
Frontiers in Public Health.2025;[Epub] CrossRef
3. Relationship between areal BMD, FRAX®, and femoral strength in community-dwelling older Asian adults
Dheeraj Jha, Manju Chandran, Dario Koller, Vee San Cheong, Anitha D. Praveen, Alexander Baker, Preeti Gupta, Ecosse L. Lamoureux, Halldór Pálsson, Stephen J. Ferguson, Benedikt Helgason
Archives of Osteoporosis.2025;[Epub] CrossRef
4. Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support
Zichen Shao, Jianfeng Wu, Qinqin Deng, Ling Cheng, Xin Huang, Weikang Sun, Weidong Liang, Huanan Li
Frontiers in Medicine.2025;[Epub] CrossRef
5. Dual-energy X-ray absorptiometry based biofidelic finite element models for simulating falls to the hip: Impact of trochanteric soft tissue thickness on fracture risk
Dheeraj Jha, Anitha D. Praveen, Alexander Baker, Anita Fung, Vee San Cheong, Preeti Gupta, Ecosse L. Lamoureux, Namki Hong, Yumie Rhee, Vanessa Jean Wen Koh, Halldór Pálsson, William R. Taylor, Angelique Wei-Ming Chan, Stephen J. Ferguson, Benedikt Helgas
Clinical Biomechanics.2025; : 106720. CrossRef
6. Osteoporosis in men—East and West: Can the twain meet? A perspective from Asia
Gerald Gui Ren Sng, Jean-Yves Reginster, Majed S. Alokail, Manju Chandran
Osteoporosis and Sarcopenia.2024; 10(4): 131. CrossRef

5,368 View
76 Download
Crossref

Case Report

Platelet Count Normalization Following Romosozumab Treatment for Osteoporosis in Patient with Immune Thrombocytopenic Purpura: A Case Report and Literature Review: Kyunghun Sung, Jeonghoon Ha; J Bone Metab 2024;31(4):335-339.
Published online November 30, 2024; DOI: https://doi.org/10.11005/jbm.24.763

Romosozumab, which is approved for the treatment of osteoporosis, has a dual-action mechanism that promotes bone formation and inhibits bone resorption. However, its association with an increased risk of major adverse cardiovascular events, as highlighted in the ARCH I study, raises concerns. The underlying pathophysiological mechanisms, possibly involving changes in platelet dynamics, are yet to be fully elucidated. Herein, we present a case of a 60-year-old Korean woman diagnosed with immune thrombocytopenic purpura and new-onset osteoporosis, who was treated with romosozumab. Subsequent to the administration of romosozumab, there was a notable elevation in her platelet count. This observation warrants further investigation into the off-target effects of romosozumab, especially its impact on hematopoietic stem cell function and platelet dynamics. This case accentuates the imperative for more comprehensive research into the systemic effects of romosozumab, particularly its involvement in hematopoiesis and cardiovascular risk, to thoroughly understand its extensive implications for patient health.

Citations

Citations to this article as recorded by

1. Romosozumab

Reactions Weekly.2025; 2043(1): 354. CrossRef

2,728 View
54 Download
Crossref

Original Articles

Bone Mineral Density and Clinical Outcome after Ankle Fracture: Hyunseong Kang, Ho-Hyup Kim, Chaemoon Lim; J Bone Metab 2024;31(3):228-235.
Published online August 31, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.3.228

Background
No gold standard exists for bone mineral density (BMD) measurement of the ankle. This study aimed to determine the correlation between bone density using Hounsfield units (HU) based on computed tomography (CT) and BMD using dual energy X-ray absorptiometry (DXA) as well as to evaluate the correlation between HU and clinical outcome of ankle fracture.
Methods
Fifty-one patients aged ≥65 years who underwent surgical treatment for trimalleolus or bimalleolus ankle fractures were included. The HU were measured at the distal tibia metaphyseal region approximately 1 cm proximal to the plafond on the axial images of preoperative CT. BMD was measured using DXA within one year before the injury. The clinical outcome was evaluated according to the Foot and Ankle Outcome Score (FAOS).
Results
Although the HU of an osteoporosis group was lower than that of a non-osteoporosis group, we observed no significant difference between the two groups. The mean HU significantly correlated with the lumbar and total lumbar spine BMD using DXA. Increased HU significantly correlated with improved clinical outcomes in three of five FAOS subscales: symptoms, pain, activity of daily living (ADL), and quality of life (QOL). In a linear regression analysis adjusted for age and body mass index, increased HU significantly correlated with improved clinical outcomes in three of five FAOS subscales: symptoms, pain, ADL, and QOL.
Conclusions
The correlations between bone density using HU and BMD and those between HU and the clinical outcome were confirmed in ankle fractures. The HU of preoperative CT might provide valuable information for predicting postoperative clinical outcomes.

Citations

Citations to this article as recorded by

1. Influencing factors of fracture in elderly ankle fracture patients in the emergency department and the construction of nomogram prediction model
Yu-Lei Mao, Yong-Kang Wei
Medicine.2026; 105(7): e45997. CrossRef

3,600 View
47 Download
Crossref

Publication Trends in Osteoporosis Treatment: A 20-Year Bibliometric Analysis: Seung-Ju Kim, Dong-Woo Lee; J Bone Metab 2024;31(2):90-100.
Published online May 31, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.2.90

Background
Osteoporosis prevalence continues to escalate with the growth of the older adult population. In this study, we aimed to investigate the profile of osteoporosis treatment-related research articles published in the past 20 years using bibliometric analysis.
Methods
We analyzed all osteoporosis treatment-related articles published between 2001 and 2020 in the Web of Science (WoS) database using bibliometric methods. In the Title search section in WoS, we searched the documents using “osteoporosis treatment”-related keywords. We used the VOSviewer software to construct the bibliometric maps of keyword co-occurrences.
Results
Our search yielded 29,738 publications, 21,556 (72.5%) were original articles and 4,529 (15.2%) were review articles and review articles (4,529). We noticed a steady increase in the publication numbers from 2001 to 2020. The overall scientific publication number in WoS increased 3.5-fold, with the five most productive countries being the USA, China, Germany, the United Kingdom, and Japan. The largest contributor was the University of California system. The most productive journals were Osteoporosis International (1,679, 6.4%), Bone (832, 3.2%), and the Journal of Bone and Mineral Research (727, 2.8%). We observed increasing trends in the appearance of denosumab and teriparatide during the last two decades. In our keyword co-occurrence analysis, we constructed four keyword clusters using VOSviewer.
Conclusions
In this study, we provided a gross overview of the visibility and productivity of research studies in osteoporosis treatment. Substantial changes have occurred in osteoporosis treatment over the last 20 years. The effector mechanism of anti-osteoporosis medications could be future hot spots in osteoporosis research. We believe that our study is a valuable guide for clinicians related to the global outputs of osteoporosis treatment.

Citations

Citations to this article as recorded by

1. Mapping a Decade of Osteoporosis and Fracture Research: A Bibliometric Analysis (2015–2025)
Oluwafemi Samson Balogun, Sunday Adewale Olaleye, Margaret Adebola Balogun, Esther Olubunmi Olaleye, Muhammad Zeshan Arshad, Keijo Haataja, Pekka Toivanen
Journal of Bone Metabolism.2026; 33(1): 94. CrossRef
2. Evidence architecture of glaucoma-related biomaterials reveals an uneven transition toward smart materials, additive manufacturing, and functional tissue engineering
Jiabin Wang, Tianyi Sui, Yabo Ma, Yang Sui, Zhe Qin, Shipeng Wang, Haojun Ma, Wenxin Xue, Daijiang Wang
Frontiers in Bioengineering and Biotechnology.2026;[Epub] CrossRef
3. Global knowledge mapping of receptor activator of nuclear factor kappa-B ligand in osteoporotic fractures: a bibliometric analysis (2001–2024)
Shuai Lu, Huaishuang Shen, Minjuan Li, Yiming Luo, Hao Sun, Xian Zhao, Jianming Chen, Ruifeng Bai, Pengli Han, Yejun Zha, Xieyuan Jiang
Frontiers in Molecular Biosciences.2025;[Epub] CrossRef
4. Trends and collaborations in discoid lupus erythematosus research: a bibliometric analysis from 2010 to 2024
Daichao Zhang, Chaoran Liang, Qiuyue Yin, Yatong Li
Frontiers in Medicine.2025;[Epub] CrossRef

4,518 View
87 Download
Crossref

Two-Year Outcomes of Daily and Twice-Weekly Teriparatide Treatment in Postmenopausal Women with Severe Osteoporosis: A Randomized Non-Blinded Prospective Study: Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Ken Okazaki; J Bone Metab 2024;31(2):162-168.
Published online May 31, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.2.162

Background
The long-term effects of daily teriparatide (D-TPTD) and twice-weekly TPTD (W-TPTD) injections are compared among postmenopausal women with severe osteoporosis.
Methods
A total of 102 patients were enrolled and randomly allocated into two groups for the administration of either D-TPTD or W-TPTD. Treatment efficacy was measured as the percentage change in bone mineral density (ΔBMD) from baseline in the lumbar spine, total hip, and femoral neck. The findings were compared between the two groups.
Results
At 24 months after treatment, the persistence rates and medication possession ratios in the D-TPTD and W-TPTD groups were 68.6% and 56.9%, and 87.8% and 92.0%, respectively. The ΔBMD in the lumbar spine, total hip, and femoral neck were 15.6%±10.2%, 5.3%± 6.3%, and 5.5%±6.2%, respectively, in the D-TPTD group; and 9.5%±7.9%, 2.3%±6.2%, and 3.1%±7.4%, respectively, in the W-TPTD group following 24 months of treatment. The ΔBMD of the lumbar spine (p=0.008) at 24 months and total hip (p=0.024) at 18 months differed significantly between the two groups.
Conclusions
D-TPTD administration resulted in a significantly higher BMD in the lumbar spine and total hip, supporting this therapeutic regimen for postmenopausal women with severe osteoporosis.

Citations

Citations to this article as recorded by

1. Author response to letter to the editor, “Comment on “Impact of baseline PINP on the BMD increase with romosozumab, teriparatide, and denosumab in treatment-naïve primary osteoporosis: A retrospective cohort study””
Yuki Etani, Takaaki Noguchi, Toshitaka Yukishima, Tomonori Kobayakawa, Masafumi Kashii, Gensuke Okamura, Atsushi Goshima, Makoto Hirao, Taihei Miura, Takuya Kurihara, Yuji Fukuda, Atsushi Sugimoto, Seiji Okada, Ken Nakata, Kosuke Ebina
Bone.2026; 203: 117727. CrossRef
2. Mechanisms limiting the long-term anabolic effects of teriparatide (PTH 1-34) on bone
Clarissa Schmal, Joy Y Wu, Abbas Jafari
JBMR Plus.2026;[Epub] CrossRef
3. Pharmacological Management of Osteoporosis in Geriatric Populations: A Comprehensive Literature Review
E. N. Dudinskaya, N. V. Brailova, O. N. Tkacheva
Russian Journal of Geriatric Medicine.2025; (2): 115. CrossRef

4,678 View
245 Download
Crossref

Retrospective Characterization of Bone Histomorphometric Findings in Clinical Patient Specimens: Linnea Sellman, Xiaoyu Tong, Inari S Burton, Heikki Kröger; J Bone Metab 2024;31(2):132-139.
Published online May 31, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.2.132

Background
Bone histomorphometry provides comprehensive information on bone metabolism and microstructure. In this retrospective study, we aimed to obtain an overview of the typical indications, referring hospitals, and histomorphometric quantification-based diagnoses of the bone tissue in our histomorphometry laboratory, the only laboratory in Finland carrying out histomorphometric examination of clinical bone biopsies.
Methods
Between January 1, 2005 and December 31, 2020, 553 clinical bone biopsies were sent to our histomorphometry laboratory for histomorphometric examination. The median age of the patients was 55 years (range, 0.2–89.9 years), 51% of them were males, and 18% comprised pediatric patients. We received bone biopsy specimens from 23 hospitals or healthcare units. The majority of the samples we sent by nephrologists.
Results
The most common bone biopsy indications were suspicion of renal osteodystrophy (ROD), unknown bone turnover status in osteoporosis, and several or untypical fractures. The most common quantitative bone histomorphometry-based diagnosis was ROD.
Conclusions
This study provides information on the clinical application of bone histomorphometry in Finland. Precise and quantitative ROD evaluation is the most common indication for bone histomorphometry, being crucial in clinical decision-making and targeted treatment of this patient group.

3,411 View
59 Download

Systematic Review and Meta-Analysis of the Effect of Osteoporosis on Reoperation Rates and Complications after Surgical Management of Lumbar Degenerative Disease: Elizabeth A. Lechtholz-Zey, Mina Ayad, Brandon S. Gettleman, Emily S. Mills, Hannah Shelby, Andy T. Ton, Ishan Shah, Jeffrey C. Wang, Raymond J. Hah, Ram K. Alluri; J Bone Metab 2024;31(2):114-131.
Published online May 31, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.2.114

Background
There is considerable heterogeneity in findings and a lack of consensus regarding the interplay between osteoporosis and outcomes in patients with lumbar degenerative spine disease. Therefore, the purpose of this systematic review and meta-analysis was to gather and analyze existing data on the effect of osteoporosis on radiographic, surgical, and clinical outcomes following surgery for lumbar degenerative spinal disease.
Methods
A systematic review was performed to determine the effect of osteoporosis on the incidence of adverse outcomes after surgical intervention for lumbar degenerative spinal diseases. The approach focused on the radiographic outcomes, reoperation rates, and other medical and surgical complications. Subsequently, a meta-analysis was performed on the eligible studies.
Results
The results of the meta-analysis suggested that osteoporotic patients experienced increased rates of adjacent segment disease (ASD; p=0.015) and cage subsidence (p=0.001) while demonstrating lower reoperation rates than non-osteoporotic patients (7.4% vs. 13.1%; p=0.038). The systematic review also indicated that the length of stay, overall costs, rates of screw loosening, and rates of wound and other medical complications may increase in patients with a lower bone mineral density. Fusion rates, as well as patient-reported and clinical outcomes, did not differ significantly between osteoporotic and non-osteoporotic patients.
Conclusions
Osteoporosis was associated with an increased risk of ASD, cage migration, and possibly postoperative screw loosening, as well as longer hospital stays, incurring higher costs and an increased likelihood of postoperative complications. However, a link was not established between osteoporosis and poor clinical outcomes.

Citations

Citations to this article as recorded by

1. Systemic Inflammatory Indexes as Predictors of Delirium, Thromboembolic Events, and Mortality After Hip Fracture and Major Orthopedic Surgery: A Meta-Analysis
Suyeon Park, Ki Tae Park, Naye Kang, Eunseo Joung, Nah Yon Kim, Byung-Ho Yoon
Journal of Korean Medical Science.2026;[Epub] CrossRef
2. Oblique-View Method Improves the Detection of cement leakage in Cement-Augmented Pedicle Screw Fixation
Kazuya Kishima, Keishi Maruo, Fumihiro Arizumi, Tetsuto Yamaura, Masaru Hatano, Hayato Oishi, Kazuma Nagao, Kei Takagi, Yuki Ishida, Toshiya Tachibana
Spine Surgery and Related Research.2026; 10(3): 440. CrossRef
3. The Impact of Frailty on Mechanical Complications Following Lumbar Fusion Surgery: A Propensity Score-matched Analysis
Tao Hu, Wei Wang, Xiaolong Chen, Shibao Lu
World Neurosurgery.2026; 211: 125033. CrossRef
4. Epidemiological (secular) trends of pelvic and acetabular fractures (2006–2022) in South Korea using a nationwide cohort data over ages 50: is it osteoporosis related?
Byung-Ho Yoon, Tae-Young Kim, HoeJeong Chung, Jaiyong Kim, Jihye Kim, Hoyeon Jang, Young-Kyun Lee
Archives of Osteoporosis.2025;[Epub] CrossRef
5. Modified vertebral bone quality score is a better predictor of cage subsidence after transforaminal lumbar interbody fusion and is superior to vertebral bone quality score
Xingyu Shao, Youwei Ai, Chen Qian, Ce Zhu, Juehan Wang, Hong Ding, Dun Luo, Zhuojie Xiao, Yongdi Wang, Chunguang Zhou, Lei Wang, Jing Tang, Limin Liu
European Spine Journal.2025; 34(9): 4222. CrossRef
6. A Systematic Review of the Effect of Osteoporosis on Radiographic Outcomes, Complications, and Reoperation Rate in Cervical Deformity
Ishan Shah, Elizabeth A. Lechtholz-Zey, Mina Ayad, Brandon S. Gettleman, Emily Mills, Hannah Shelby, Andy Ton, William J. Karakash, Apurva Prasad, Jeffrey C. Wang, Ram K. Alluri, Raymond J. Hah
Journal of Clinical Medicine.2025; 14(17): 6196. CrossRef
7. Expandable Cage in Minimally Invasive Transforaminal Lumbar Interbody Fusion: Comparative Data with Static Cage from a Single Institution and a Single Surgeon
Dongkyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Jeong Yoon Park
World Neurosurgery.2025; 202: 124428. CrossRef
8. CT-Mapped Fusion Patterns After 360° Transforaminal Lumbar Interbody Fusion (TLIF) for Degenerative Spondylolisthesis: High Facet and Interbody Fusion Rates With Limited Clinical Correlates
Carla García-Ramos, Diego-Alberto Nuñez-Arreola, Diana-Laura Hernandez Moctezuma , Alejandro Antonio Reyes-Sanchez, Armando Alpizar-Aguirre, Baron Zarate-Kalfopulos, Irving O Estevez-Garcia, Ernesto Roldan-Valadez
Cureus.2025;[Epub] CrossRef
9. Risk factors and treatment strategies for adjacent segment disease following spinal fusion (Review)
Xing Huang, Yong Cai, Kai Chen, Qiang Ren, Bo Huang, Gang Wan, Yuchen Wang, Jincheng Lin, Jun Zhao
Molecular Medicine Reports.2024;[Epub] CrossRef

5,392 View
94 Download
Crossref

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis: Kyung-Hag Lee, Guhyun Lee, Taehyun Lee, Dong-Won Byun, Yong-Chan Ha; J Bone Metab 2024;31(1):63-74.
Published online February 29, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.1.63

Background
Patient perception is a key element in improving compliance with medications for osteoporosis. This study evaluated the awareness, perception, sources of information, and knowledge of osteoporosis among Korean women with osteoporosis.
Methods
A questionnaire survey was conducted from July 22, 2021 to 13 August 2021. Patients who were followed up in endocrinology (Endo), orthopedic surgery (OS), and gynecology (GY) were recruited (N=40, 40, and 20 in each group). Patients were allocated according to their age, as follows: 15, 15, and 10 patients in their 60s, 70s, and 80s for Endo and OS, and 10 and 10 patients in their 60s and 70s for GY. The questionnaire was composed of the following topics: patient journey to the hospital, drug-related issues, communication with medical doctors, patient knowledge, and sources of information about osteoporosis.
Results
The results of medical check-ups were the most common reason for patient visits to the hospital for an initial diagnosis of osteoporosis (61%). A knowledge gap regarding mortality, refracture, and drug-induced osteoporosis was observed. Doctors were the most preferred and trustful source of information, while health-related TV shows were the second most common source of information. Patients with OS reported lower perceived severity and higher drug discontinuation, along with a higher proportion of fractures, as the initial reasons for hospital visits for osteoporosis.
Conclusions
Variations in perceptions according to the issue and group were identified. These should be considered during patient consultations to improve compliance with osteoporosis treatment.

Citations

Citations to this article as recorded by

1. Living with osteoporosis: a qualitative descriptive study
Mara Tormen, Chiara Tedesco, Vicente Bernalte-Martì, Angela Cuoco, Anna Maria Carratoni, Gianluca Pucciarelli, Ercole Vellone, Maddalena De Maria, Emanuela Basilici Zannetti, Noemi Cittadini, Annalisa Pennini, Umberto Tarantino, Rosaria Alvaro
Archives of Osteoporosis.2025;[Epub] CrossRef

5,049 View
81 Download
Crossref

Association between Fat Mass and Obesity-Related Transcript Polymorphisms and Osteoporosis Phenotypes: Krisel De Dios, Ngoc Huynh, Thach S. Tran, Jacqueline R. Center, Tuan V. Nguyen; J Bone Metab 2024;31(1):48-55.
Published online February 29, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.1.48

Background
Common variants in the fat mass and obesity-related transcript (FTO) gene are related to body mass index and obesity, suggesting its potential association with bone mineral density (BMD) and fracture risk. This study sought to define the association between FTO gene variants and the following phenotypes: (1) BMD; (2) bone loss; and (3) fracture risk.
Methods
This analysis was based on the Dubbo Osteoporosis Epidemiology Study that included 1,277 postmenopausal women aged ≥60 years living in Dubbo, Australia. BMD at the femoral neck and lumbar spine was measured biennially by dual energy X-ray absorptiometry (GE Lunar). Fractures were radiologically ascertained. Six single nucleotide polymorphisms (SNPs; rs1421085, rs1558902, rs1121980, rs17817449, rs9939609, and rs9930506) of the FTO gene were genotyped using TaqMan assay.
Results
Women homozygous for the minor allele (GG) of rs9930506 had a significantly higher risk of hip fracture (adjusted hazard ratio, 1.93; 95% confidence interval, 1.15–3.23) than those homozygous for the major allele (AA) after adjusting for potential confounding effects. Similar associations were also observed for the minor allele of rs1121980. However, there was no significant association between the FTO SNPs and BMD or the rate of bone loss.
Conclusions
Common variations in the FTO gene are associated with a hip fracture risk in women, and the association is not mediated through BMD or bone loss.

Citations

Citations to this article as recorded by

1. MKRN1 Regulates RANKL‐Induced Differentiation Via Akt and AMPK Pathways
Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, Jeong‐Tae Koh, Nacksung Kim
Journal of Cellular Physiology.2025;[Epub] CrossRef
2. Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women
Daniela Greere, Sara Haydar, Florin Grigorescu, Dana Manda, Gabriela Voicu, Corinne Lautier, Catalina Poiana
Genes.2024; 15(9): 1152. CrossRef

6,775 View
91 Download
Crossref

Impact of COVID-19 on the Incidence of Fragility Fracture in South Korea: Seungjin Baek, Ye-Jee Kim, Beom-Jun Kim, Namki Hong; J Bone Metab 2024;31(1):31-39.
Published online February 29, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.1.31

Background
The coronavirus disease 2019 (COVID-19) pandemic and the consequent social distancing period are thought to have influenced the incidence of osteoporotic fracture in various ways, but the exact changes have not yet been well elucidated. The purpose of this study was to investigate the impact of the COVID-19 pandemic on the incidence of osteoporotic fracture using a nationwide cohort.
Methods
The monthly incidence rates of vertebral; hip; and non-vertebral, non-hip fractures were collected from a nationwide database of the Korean National Health Insurance Review and Assessment from July 2016 to June 2021. Segmented regression models were used to assess the change in levels and trends in the monthly incidence of osteoporotic fractures.
Results
There was a step decrease in the incidence of vertebral fractures for both males (6.181 per 100,000, P=0.002) and females (19.299 per 100,000, P=0.006). However, there was a negative trend in the incidence of hip fracture among both males (-0.023 per 100,000 per month, P=0.023) and females (-0.032 per 100,000 per month, P=0.019). No impact of COVID-19-related social distancing was noted.
Conclusions
In conclusion, during the early days of the COVID-19 pandemic, vertebral fracture incidence considerably decreased with the implementation of social distancing measures.

Citations

Citations to this article as recorded by

1. Trends of incidence and 1-year mortality of vertebral fractures in Korea using nationwide claims data
Young-Kyun Lee, Jung-Wee Park, Tae-Young Kim, Jihye Kim, Hoyeon Jang, Jaiyong Kim, Yong-Chan Ha
Archives of Osteoporosis.2025;[Epub] CrossRef
2. Global, regional, and national burden of vertebral fractures among women from 1990 to 2021: a systematic analysis based on the global burden of disease study
Junpeng Liu, Xingchen Yao, Zhiheng Zhao, Xinglin Liu, Sheyang Xu, Bowen Lu, Xianglong Meng
European Spine Journal.2025;[Epub] CrossRef

5,365 View
65 Download
Crossref

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women: Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone; J Bone Metab 2024;31(1):21-30.
Published online February 29, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.1.21

Background
No consensus exists regarding which anthropometric measurements are related to bone mineral density (BMD), and this relationship may vary according to sex and age. A large Japanese cohort was analyzed to provide an understanding of the relationship between BMD and anthropometry while adjusting for known confounding factors.
Methods
Our cohort included 10,827 participants who underwent multiple medical checkups including distal forearm BMD scans. Participants were stratified into four groups according to age (≥50 years or <50 years) and sex. The BMD values were adjusted for confounding factors, after which single and partial correlation analyses were performed. The prevalence of osteopenia was plotted for each weight index (weight or body mass index [BMI]) class.
Results
Cross-sectional studies revealed that weight was more favorably correlated than BMI in the older group (R=0.278 and 0.212 in men and R=0.304 and 0.220 in women, respectively), whereas weight and BMI were weakly correlated in the younger age groups. The prevalence of osteopenia exhibited a negative linear relationship with weight among older women ≥50 years of age, and an accelerated increase was observed with decreasing weight in older men weighing <50 kg and younger women weighing <60 kg. When weight was replaced with BMI, the prevalence was low in most subgroups classified by weight.
Conclusions
Weight, rather than BMI, was the most important indicator of osteopenia but it might not be predictive of future bone loss.

7,033 View
74 Download

Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study: Carrie Ye, Finlay A. McAlister, Debbie Bellerose, Meng Lin; J Bone Metab 2024;31(1):13-20.
Published online February 29, 2024; DOI: https://doi.org/10.11005/jbm.2024.31.1.13

Background
In this pre-planned variation of the Comparing Strategies Targeting Osteoporosis to Prevent Fractures After an Upper Extremity Fracture (C-STOP) trial, we investigated whether adherence-specific coaching by the case manager (CM) further improved the adherence and persistence rates compared to those seen in the C-STOP trial.
Methods
We conducted a prospective observational cohort study of community-dwelling adults 50 years or older who suffered an upper-extremity fracture and were not previously treated with osteoporosis medications, to assess whether a well-trained CM can partner with patients to improve adherence to and persistence with oral bisphosphonate intake. The primary outcome was adherence (taking > 80% of prescribed doses) to oral bisphosphonate intake at 12 months after study enrollment. Secondary outcomes included primary adherence to and 12-month persistence with oral bisphosphonate and calcium and vitamin D supplement intake at 12 months.
Results
The study cohort consisted of 84 participants, of which 30 were prescribed an oral bisphosphonate. Twenty-two (73.3%) started treatment within 3 months. The adherence rate at 12 months was 77.3%. The persistence rate at 12 months was 95.5%. Of those not prescribed an oral bisphosphonate, 62.8% were taking supplemental calcium and 93.0% were taking supplemental vitamin D at 12 months. Depression was a significant predictor of 12-month non-adherence (adjusted odds ratio, 9.8; 95% confidence interval, 1.2–81.5).
Conclusions
Adherence-specific coaching by a CM did not further improve the level of medication adherence achieved in the original C-STOP study. Importantly, these results can inform adherence in future intervention studies.

5,006 View
78 Download

Knowledge, Attitude, and Behavior Levels of Postmenopausal Women about Osteoporosis: Hazal Saltık, Furkan Öztürk, Canan Emiroğlu, Baki Hekimoğlu, Cenk Aypak; J Bone Metab 2023;30(4):347-354.
Published online November 30, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.4.347

Background
Osteoporosis can be delayed by providing accurate and adequate information to people at risk. Therefore, we aimed to determine the knowledge, attitude, and behavior levels of women in the postmenopausal period, which is the largest group at risk.
Methods
The study was conducted in a tertiary Training and Research Hospital between 1 December 2018 and 1 May 2019 in 225 postmenopausal women who applied to the Family Medicine outpatient clinic and bone mineral density (BMD) outpatient clinics for BMD measurement or had previously had this measurement at least once. A questionnaire evaluating the knowledge, attitudes, and behavior levels related to osteoporosis was applied to all patients included in the study.
Results
The mean age was 58.05±9.1 years. The median osteoporosis knowledge score was 7 out of 19 points. A total of 119 (52.9%) had low knowledge scores and 106 (47.1%) had higher knowledge scores. Of the individuals with high scores, 40 (37.7%) were smoking, 64 (60.4%) did not sunbathe, 89 (84%) did not consume the recommended daily amount of calcium, and 58 (54.7%) were not exercising in the recommended time. It was seen that those who were university graduates, who had previously learned about osteoporosis from a health professional, and who had a family history of osteoporosis had higher knowledge levels.
Conclusions
Even in postmenopausal women who are aware that they are in the risk group and that they should have BMD, their knowledge, attitude, and behavior levels on osteoporosis were found to be quite low.

Citations

Citations to this article as recorded by

1. Functional Limitations and Fall Risk in Post-Menopausal Women with and without Osteoporosis: A Cross-Sectional Study
Maryam, Sana Farooq, Hajra Munaf, Hania Mansoor
The Healer Journal of Physiotherapy and Rehabilitation Sciences.2026; 6(1): 143. CrossRef
2. Portuguese adaptation and psychometric validation of the Osteoporosis Knowledge Assessment Tool in community-dwelling adults
Tiago Silva, Georgina Pimentel, Elsa Mateus, Cristina Baixinho, Andreia Costa, Ricardo J.O. Ferreira
International Journal of Orthopaedic and Trauma Nursing.2026; 62: 101297. CrossRef
3. Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use
Jeonghoon Ha, Youn-Ju Lee, Jinyoung Kim, Chaiho Jeong, Yejee Lim, Jeongmin Lee, Ki-Hyun Baek
Endocrinology and Metabolism.2025; 40(1): 47. CrossRef
4. Epidemiological (secular) trends of pelvic and acetabular fractures (2006–2022) in South Korea using a nationwide cohort data over ages 50: is it osteoporosis related?
Byung-Ho Yoon, Tae-Young Kim, HoeJeong Chung, Jaiyong Kim, Jihye Kim, Hoyeon Jang, Young-Kyun Lee
Archives of Osteoporosis.2025;[Epub] CrossRef
5. Risk of fragility fracture of pelvis in endometrial cancer survivors : A national claim database study
Ki-Tae Park, Jung-Wee Park, Dong-Hoon Lee, Ye Jhin Jeon, Jean Kyung Bak, Bit-Na Yoo, Youn Kyung Chung, Byung-Ho Yoon, Young-Kyun Lee
Archives of Osteoporosis.2025;[Epub] CrossRef
6. Knowledge, attitudes, and practices toward osteoporosis: a questionnaire survey
Min Xue, Jiesheng Xia, Xiaohui You, Xun Zhu, Li Zheng, Qi Wei, Miao Zheng, Jialong Tao, Yuntian Shen, Qi Zhou, Jiani Qian, Minjie Chu, Youjia Xu
Frontiers in Public Health.2025;[Epub] CrossRef
7. A Risk Reduction Program for Osteoporosis Complications among Postmenopausal Women: A Quasi- Experimental Design
Fatin Abdel Raheem Mostafa Zewail, Faten Khayrat El-Guindi, Ferial Fouad Melika
BMC Women's Health.2025;[Epub] CrossRef
8. Awareness About Osteoporosis Among the General Population Based on the Osteoporosis Knowledge Assessment Tool (OKAT): A Cross-Sectional Study in the Northern Border Region of Saudi Arabia
Ekramy Elmorsy, Amgad N Elsawi, Nasser M Alruwaili, Abdulelah H Alruwaili, Sultan N Alanazi, Khalid R Alenezi
Cureus.2024;[Epub] CrossRef
9. Knowledge, Attitudes, Practices, and Awareness Levels Among Indian Postmenopausal Women About Osteoporosis and Its Relationship With Sociodemographic Factors: A Cross-Sectional Study From Northern India
Amit Kale, Nitish Khandelwal, Bhavya Sirohi, Omna Shaki, Sanjay Rai
Cureus.2024;[Epub] CrossRef

5,510 View
107 Download
Crossref

Bone Health Status of Children with Spinal Muscular Atrophy: Joanna Yuet-Ling Tung, Tsz-Kit Chow, Monique Wai, Jasmine Lo, Sophelia Hoi Shan Chan; J Bone Metab 2023;30(4):319-327.
Published online November 30, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.4.319

Background
Spinal muscular atrophy (SMA) is a group of rare, inherited neuromuscular disorders. Bone health is often a neglected issue in children with SMA. This study aimed to evaluate the bone health status of children with SMA in Hong Kong.
Methods
This retrospective study included children with SMA who were managed in the Neuromuscular Disorder Clinics of 2 quaternary centers in Hong Kong. Bone health status was assessed by fracture history, bone mineral density (BMD) measured by dual energy X-ray absorptiometry, and serum 25-hydroxy-vitamin D (25[OH]D) level.
Results
Thirty-two children were included (males, 12). The median age was 10.8 years. BMD assessments were performed in 17 patients (SMA type 1=2, type 2=8, type 3=7). Low BMD was observed in 16 out of 17 patients. Four had a history of long bone fractures and were started on bisphosphonates. SMA types, age at last visit, sex, ambulation, and 25(OH)D level were not associated with fracture history or BMD Z-scores. Only one fulfilled the 2019 International Society for Clinical Densitometry (ISCD) pediatric definition of osteoporosis, with both low BMD and a history of clinically significant fracture.
Conclusions
Children with SMA on disease-modifying treatments commonly had Low BMD and a history of fractures, but osteoporosis was uncommon according to the 2019 ISCD pediatric definition. A special definition of osteoporosis may be needed for this high-risk group.

Citations

Citations to this article as recorded by

1. Italian survey on evolving SMA care with disease-modifying therapies: a consensus workshop on nutrition, swallowing, respiratory and rehabilitation care
Stefania Corti, Valeria Sansone, Ilaria Bitetti, Noemi Brolatti, Giulio Gadaleta, Agata Katia Patanella, Giorgia Coratti, Eugenio Mercuri
Neuromuscular Disorders.2025; 48: 105278. CrossRef
2. Awareness of bone strength in patients with neuromuscular disorders: ERN EURO-NMD clinician survey and European patient survey
M.T.A. Kruse, B.A.S. Olde Dubbelink, M. Kroneman, I. de Groot, S. Schlüter, M. de Visser, T. Evangelista, A. Moretti, D. Weber, L.M. Ward, N.C. Voermans, A. D'Amico, J. Baets, M. Baumann, N. van der Beek, J. De Bleecker, A. Bruijnes, K. Claeys, C. Bruno,
Journal of the Neurological Sciences.2025; 472: 123420. CrossRef
3. Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders
Haikuan Yu, Taojin Feng, Chengcheng Zhang, Zhouguang Jiao, Wenkai Fan, Rongxian Jiang, Dewen Kong, Fubing Li
Frontiers in Pharmacology.2025;[Epub] CrossRef
4. Systematic Review and Meta-Analysis of the Effect of Osteoporosis on Reoperation Rates and Complications after Surgical Management of Lumbar Degenerative Disease
Elizabeth A. Lechtholz-Zey, Mina Ayad, Brandon S. Gettleman, Emily S. Mills, Hannah Shelby, Andy T. Ton, Ishan Shah, Jeffrey C. Wang, Raymond J. Hah, Ram K. Alluri
Journal of Bone Metabolism.2024; 31(2): 114. CrossRef
5. 274th ENMC international workshop: recommendations for optimizing bone strength in neuromuscular disorders. Hoofddorp, The Netherlands, 19–21 January 2024
Nicol C. Voermans, Anne T.M. Dittrich, Sara Liguori, Chiara Panicucci, Antimo Moretti, David R. Weber, Leanne M. Ward, Ingrid de Groot, Michela Guglieri, Claire Wood, Sara Liguori, Giovanni Iolascon, Anna Kostera-Pruszczyk, Corrie E. Erasmus, Marianne de
Neuromuscular Disorders.2024; 43: 1. CrossRef
6. Low bone mineral density and its influencing factors in spinal muscular atrophy without disease-modifying treatment: a single-centre cross-sectional study
Chuan Liu, Dandan Yang, Lekai Luo, Xinmao Ma, Xijian Chen, Yi Liao, Gang Ning, Haibo Qu
BMC Pediatrics.2024;[Epub] CrossRef
7. Epigenetic-Based Therapeutics for Aging: Uncovering Mechanisms and Advancing Interventions for Disorders That Emerge with Age
Hiroshi Nakamura, Yuta Kondo, Masaki Shimizu, Ryo Takahashi, Takashi Mori
Specialty Journal of Pharmacognosy, Phytochemistry, and Biotechnology.2021; 1(1): 138. CrossRef

6,034 View
122 Download
Crossref

Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea: Jun-Il Yoo, So Young Park, Deog-Yoon Kim, Jeonghoon Ha, Yumie Rhee, Namki Hong, Jung-Taek Kim, Hyon-Seung Yi, Bu Kyung Kim, Young-Kyun Lee, Yong-Chan Ha, Yun Kyung Jeon, Ha-Young Kim, Seong Hee Ahn, Seongbin Hong, Sang-Yeob Lee; J Bone Metab 2023;30(4):311-317.
Published online November 30, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.4.311

Background
This study aimed to investigate real-world data of C-terminal telopeptide (CTX), propeptide of type I collagen (P1NP), and osteocalcin through present multicenter clinical study, and retrospectively analyze the usefulness of bone turnover markers (BTMs) in Koreans.
Methods
The study focused on pre- and post-menopausal patients diagnosed with osteoporosis and excluded patients without certain test results or with test intervals of over 1 year. The demographic data and 3 BTMs (CTX, P1NP, and osteocalcin) were collected. The patients were classified by demographic characteristics and the BTM concentrations were analyzed by the group.
Results
Among women with no history of fractures, the levels of P1NP (N=2,100) were 43.544±36.902, CTX (N=1,855) were 0.373 ±0.927, and osteocalcin (N=219) were 10.81 ±20.631. Among men with no history of fractures, the levels of P1NP (N=221) were 48.498±52.892, CTX (N=201) were 0.370±0.351, and osteocalcin (N=15) were 7.868 ±10.674. Treatment with teriparatide increased the P1NP levels after 3 months in both men and women, with a 50% increase observed in women. Similarly, treatment with denosumab decreased the CTX levels after 3 months in both men and women, with a reduction of 50% observed in women.
Conclusions
The results of this study can contribute to the accurate assessment of bone replacement status in Koreans. We also provide the P1NP level in the Korean population for future comparative studies with other populations.

Citations

Citations to this article as recorded by

1. Identification of key predictors of postmenopausal osteoporosis from routine clinical indicators using explainable machine learning
Yang Guo, Shuai Jiang, Wei Zhu, Longwang Tan, Chuang Liu, Yongjun Jia, Chi Zhang, Kok-Yong Chin, Gaetano Paride Arcidiacono
PLOS One.2026; 21(6): e0351334. CrossRef
2. Comparative Analysis of Myokines and Bone Metabolism Markers in Prepubertal Vegetarian and Omnivorous Children
Jadwiga Ambroszkiewicz, Joanna Gajewska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Magdalena Chełchowska
Nutrients.2024; 16(13): 2009. CrossRef

5,323 View
134 Download
Crossref

Review Article

Position Statement: Postmenopausal Osteoporosis Treatment Strategies in Korea: So Young Park, Se Hwa Kim, Young-Kyun Lee, Jung-Ho Shin, Yong-Chan Ha, Ho Yeon Chung; J Bone Metab 2023;30(4):289-295.
Published online November 30, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.4.289

Classifying patients with osteoporosis according to fracture risk and establishing adequate treatment strategies is crucial to effectively treat osteoporosis. The Korean Society for Bone and Mineral Research has issued a position statement regarding appropriate treatment strategies for postmenopausal osteoporosis. According to previous fragility fracture history, bone mineral density (BMD) test results, fracture risk assessment tool, and several clinical risk factors, fracture risk groups are classified into low, moderate, high, and very-high-risk groups. In high-risk groups, bisphosphonates (BPs) and denosumab are recommended as first-line therapies. Sequential BP treatment after denosumab discontinuation is required to prevent the rebound phenomenon. In the very high-risk group, anabolic drugs (teriparatide or romosozumab) are recommended as a first-line therapy; sequential therapy with antiresorptive agents is required to maintain BMD gain and reduce fracture risk. Fracture risk was reassessed annually, and the treatment plan was determined based on the results, according to the osteoporosis treatment algorithm for fracture risk.

Citations

Citations to this article as recorded by

1. Effect of a one time guideline based educational video intervention on osteoporosis related knowledge
Anna-Lena Hauser, Javier-Fernando Noriega Urena, Levan Saatashvili, Firas Esmail, Tobias Lange, Tobias Ludger Schulte, Alexander von Glinski
Archives of Orthopaedic and Trauma Surgery.2026;[Epub] CrossRef
2. Trends in Osteoporosis Prevalence in Korea Using Korea National Health and Nutrition Examination Survey (KNHANES) 2024 and 2008–2011: The KSBMR KNHANES DXA Task Force Report
Namki Hong, Jeonghoon Ha, Jun-Il Yoo, Seong Hee Ahn, Young-Kyun Lee, Hyun Sik Gong, Yong-Chan Ha, Ki-Hyun Baek, Yumie Rhee
Journal of Bone Metabolism.2026; 33(2): 141. CrossRef
3. Effects of denosumab and zoledronic acid on postmenopausal osteoporosis, bone density, and fat-free mass
Jeonghoon Ha, Jinyoung Kim, Chaiho Jeong, Jeongmin Lee, Yejee Lim, Ki-Hyun Baek
Archives of Osteoporosis.2025;[Epub] CrossRef
4. Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use
Jeonghoon Ha, Youn-Ju Lee, Jinyoung Kim, Chaiho Jeong, Yejee Lim, Jeongmin Lee, Ki-Hyun Baek
Endocrinology and Metabolism.2025; 40(1): 47. CrossRef
5. Twenty-Year Trends in Osteoporosis Treatment and Post-Fracture Care in South Korea: A Nationwide Study
Kyoung Jin Kim, Kyoung Min Kim, Young-Kyun Lee, Jihye Kim, Hoyeon Jang, Jaiyong Kim, Ha Young Kim
Journal of Bone Metabolism.2025; 32(1): 57. CrossRef
6. The prevention of osteoporotic vertebral fractures in eastern and in western countries
Fjorda Koromani, Jiawei Li, Hiroshi Hagino, Richard Eastell, Annegreet Vlug, Ling Wang, Hua Yue, Yong-Chan Ha, Steven Cummings, Salvatore Minisola, Claus-C. Glüer, Ling Oei
Bone Reports.2025; 25: 101851. CrossRef
7. Epidemiological (secular) trends of pelvic and acetabular fractures (2006–2022) in South Korea using a nationwide cohort data over ages 50: is it osteoporosis related?
Byung-Ho Yoon, Tae-Young Kim, HoeJeong Chung, Jaiyong Kim, Jihye Kim, Hoyeon Jang, Young-Kyun Lee
Archives of Osteoporosis.2025;[Epub] CrossRef
8. Short-term anabolic agent and sequential therapy to improve bone mineral density and bone turnover markers in patients with osteoporotic hip fractures
Jun Young Park, Jun-Young Lim, Tae Kang Kim, Byung Woo Cho, Hyuck Min Kwon, Kwan Kyu Park, Woo-Suk Lee
Journal of Orthopaedic Surgery and Research.2025;[Epub] CrossRef
9. Factors Associated with Discordance between Hip and Spine Bone Mineral Density
Weon Kim, Min Kyu Choi
Korean Journal of Family Practice.2025; 15(3): 167. CrossRef
10. Effects of Sequential Anti-Resorptive Agents on Bone Mineral Density Following Denosumab Withdrawal: A Multicenter Real-World Study in Korea (MAXCARE Study)
Jeonghoon Ha, Kyong Yeun Jung, Kyoung Jin Kim, Seong Hee Ahn, Hyo-Jeong Kim, Yoon-Sok Chung
Endocrinology and Metabolism.2025; 40(5): 748. CrossRef
11. Efficacy comparison of 6-month romosozumab plus denosumab versus 12-month romosozumab in Koreans
Seung-Eun Lee, Seong Hee Ahn, Beom-Jun Kim, Seung Hun Lee, Ha Young Kim, Seongbin Hong, Jung-Min Koh
European Journal of Endocrinology.2025; 193(5): 527. CrossRef
12. Denosumab and the Rebound Effect: Current Aspects of Osteoporosis Therapy (Review)
N. Yu. Velts, O. V. Velts, R. N. Alyautdin
Safety and Risk of Pharmacotherapy.2024; 12(2): 190. CrossRef
13. Denosumab in Osteoporosis: Predicting Long-Term Efficacy beyond 10 Years
Jeongmin Lee, Youn-Ju Lee, Jeonghoon Ha
Journal of Bone Metabolism.2024; 31(3): 246. CrossRef

11,507 View
288 Download
Crossref

Original Articles

The Effect of Denosumab in Elderly Patients Regarding Bone Density and Fracture Risk: Sung-Hyun Yoon, Karam Kim, Ki-Choul Kim; J Bone Metab 2023;30(3):275-282.
Published online August 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.3.275

Background
With an aging population, the importance of treating and diagnosing osteoporosis is increasing. Osteoporosis, previously known as a resorptive change primarily related to endocrinological mechanisms, is also being approached as a phenomenon of senile change. Denosumab is gaining popularity among osteoporosis medications due to its ability to increase bone mineral density (BMD) and the economic benefit arising from the 6-month cycle. In line with previous literature, this study aimed to examine the BMD-augmenting effect of denosumab through which it reduces fracture risk in individuals aged over 80 years.
Methods
We reviewed patients who received denosumab between 2018 and 2022 with a minimum clinical observation period of 12 months. BMD was measured every 12 months, and patients were classified per their period of denosumab use. Fracture risk was evaluated using the fracture risk assessment tool (FRAX) and fracture incidence during the observation period were assessed.
Results
Among 155 patients, a significant increase in BMD was observed at 3 sites: the lumbar spine, femoral neck, and total hip (p<0.001, p<0.001, and p=0.001, respectively). The patients were divided according to the length of clinical follow-up they received, and similar results were found in all subgroups. Fracture risk assessment was performed using FRAX and the incidence of fracture events during follow-up. FRAX significantly decreased in all subgroups except those who received 24 months of follow-up (p=0.003, p=0.41, p=0.001 in the 12, 24, and ≥36 months groups, respectively).
Conclusions
Denosumab use resulted in long-term BMD increase and reduced fracture risk in individuals aged 80 and above.

Citations

Citations to this article as recorded by

1. Postoperative osteoporosis therapy and risk of re-fracture in elderly patients with hip fractures: a multicenter retrospective cohort study
Xin Li, Yue Zhao, Lin Cheng, Chen Yan, Dongsheng Guo, Yixin Liang, Yuefu Dong, Jian Zhang
Osteoporosis International.2026; 37(3): 659. CrossRef
2. Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use
Jeonghoon Ha, Youn-Ju Lee, Jinyoung Kim, Chaiho Jeong, Yejee Lim, Jeongmin Lee, Ki-Hyun Baek
Endocrinology and Metabolism.2025; 40(1): 47. CrossRef
3. Antiresorptive Therapy for Osteoporosis in Older Subjects
Anne Sophie Sølling, Natasha Amran Laursen, Torben Harsløf, Bente Lomholt Langdahl
Gerontology.2025; 71(4): 297. CrossRef
4. The use of denosumab in osteoporosis – an update on efficacy and drug safety
Dima L. Diab, Nelson B. Watts
Expert Opinion on Drug Safety.2024; 23(9): 1069. CrossRef

4,894 View
94 Download
Crossref

Osteoporosis Feature Selection and Risk Prediction Model by Machine Learning Using a Cross-Sectional Database: Yonghan Cha, Sung Hyo Seo, Jung-Taek Kim, Jin-Woo Kim, Sang-Yeob Lee, Jun-Il Yoo; J Bone Metab 2023;30(3):263-273.
Published online August 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.3.263

Background
The purpose of this study was to verify the accuracy and validity of using machine learning (ML) to select risk factors, to discriminate differences in feature selection by ML between men and women, and to develop predictive models for patients with osteoporosis in a big database.
Methods
The data on 968 observed features from a total of 3,484 the Korea National Health and Nutrition Examination Survey participants were collected. To find preliminary features that were well-related to osteoporosis, logistic regression, random forest, gradient boosting, adaptive boosting, and support vector machine were used.
Results
In osteoporosis feature selection by 5 ML models in this study, the most selected variables as risk factors in men and women were body mass index, monthly alcohol consumption, and dietary surveys. However, differences between men and women in osteoporosis feature selection by ML models were age, smoking, and blood glucose level. The receiver operating characteristic (ROC) analysis revealed that the area under the ROC curve for each ML model was not significantly different for either gender.
Conclusions
ML performed a feature selection of osteoporosis, considering hidden differences between men and women. The present study considers the preprocessing of input data and the feature selection process as well as the ML technique to be important factors for the accuracy of the osteoporosis prediction model.

Citations

Citations to this article as recorded by

1. Machine Learning-Based Automatic Diagnosis of Osteoporosis Using Bone Mineral Density Measurements
Nilüfer Aygün Bilecik, Levent Uğur, Erol Öten, Mustafa Çapraz
Journal of Clinical Medicine.2026; 15(2): 549. CrossRef
2. Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study
Aiguo Liu, Ting Ying, Shuang Deng, Chenxu Wang, Ziwen Zhao, Sitong Zhang, Han Xiao, Chengqing Yi, Dejian Li
Frontiers in Aging.2025;[Epub] CrossRef
3. Artificial intelligence in nutrition and ageing research – A primer on the benefits
Pol Grootswagers, Tijl Grootswagers
Maturitas.2025; 200: 108662. CrossRef
4. Emerging applications of feature selection in osteoporosis research: from biomarker discovery to clinical decision support
Jihan Wang, Yangyang Wang, Jia Ren, Zitong Li, Lei Guo, Jing Lv
Journal of Bone and Mineral Research.2025; 40(10): 1106. CrossRef
5. A Novel Approach for Diagnosis of Osteoporosis Integrating Clinical Decision Support with Generative Adversarial Networks
M. Raja, Avulapalli Jayaram Reddy
International Journal of Computational Intelligence Systems.2025;[Epub] CrossRef

6,360 View
76 Download
Crossref

Review Article

Position Statement: Atypical Femoral Fracture from the Korean Society for Bone and Mineral Research in 2023: Jae-Hwi Nho, Byung-Woong Jang, Dong Woo Lee, Jae-Hyun Kim, Tae Kang Lim, Soo Min Cha, Dong-Kyo Seo, Yong-Geun Park, Dong-Geun Kang, Young-Kyun Lee, Yong-Chan Ha; J Bone Metab 2023;30(3):209-217.
Published online August 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.3.209

As the aging population increases, the number of patients with osteoporosis is gradually rising. Osteoporosis is a metabolic bone disease characterized by low bone mass and the microarchitectural deterioration of bone tissue, resulting in reduced bone strength and an increased risk of low-energy or fragility fractures. Thus, the use of anti-resorptive agents, such as bisphosphonates (BPs), to prevent osteoporotic fractures is growing annually. BPs are effective in reducing hip and other fractures. However, the longer a patient takes BPs, the higher the risk of an atypical femoral fracture (AFF). The exact mechanism by which long-term BP use affects the development of AFFs has not yet been clarified. However, several theories have been suggested to explain the pathogenesis of AFFs, such as suppressed bone remodeling, impaired bone healing, altered bone quality, and femoral morphology. The management of AFFs requires both medical and surgical approaches. BPs therapy should be discontinued immediately, and calcium and vitamin D levels should be evaluated and supplemented if insufficient. Teriparatide can be used for AFFs. Intramedullary nailing is the primary treatment for complete AFFs, and prophylactic femoral nailing is recommended if signs of an impending fracture are detected.

Citations

Citations to this article as recorded by

1. Atypical femoral fractures: an update
Won-Tae Cho, Jeong-Hyun Koh, Seungyeob Sakong, Jung-Taek Kim
Journal of Musculoskeletal Trauma.2025; 38(2): 41. CrossRef
2. Asian Federation of Osteoporosis Societies 2025 consensus on atypical femoral fractures in patients with osteoporosis
Thanut Valleenukul, Thawee Songpatanasilp, Unnop Jaisamrarn, Surapong Anuraklekha, Varalak Srinonprasert, Sumapa Chaiamnuay, Aasis Unnanuntana, Lalita Wattanachanya, Hataikarn Nimitphong, Noratep Kulachote, Ong-art Phruetthiphat, Rahat Jarayabhand, Tanawa
Osteoporosis and Sarcopenia.2025; 11(4): 111. CrossRef
3. Does the Nonunion Rate of Atypical Femoral Fractures Differ According to Fracture Site?: A Meta-Analysis
Byung-Ho Yoon, Minsub Kim, Young Hak Roh
Clinics in Orthopedic Surgery.2024; 16(4): 533. CrossRef
4. Incidence and clinical course of femoral localized periosteal thickening and atypical femoral fracture over a 10-year period in patients with autoimmune inflammatory rheumatic disease
Hiroe Sato, Naoki Kondo, Yoichi Kurosawa, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Daisuke Kobayashi, Takeshi Nakatsue, Yoko Wada, Junichiro James Kazama, Takeshi Kuroda, Masaaki Nakano, Naoto Endo, Ichiei Narita
JBMR Plus.2024;[Epub] CrossRef
5. Atypical femur fracture in two patients treated with denosumab: case reports of a patient undergoing maintenance hemodialysis and a kidney transplant recipient, with a literature review of the denosumab used to treat these patients
Ryoichi Miyazaki, Kyoko Miyagi, Sun Hirayama, Tatsuto Miyanaga
Renal Replacement Therapy.2024;[Epub] CrossRef

12,517 View
185 Download
Crossref

Original Articles

Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial: Chaiho Jeong, Jeonghoon Ha, Jun-Il Yoo, Young-Kyun Lee, Jung Hee Kim, Yong-Chan Ha, Yong-Ki Min, Dong-Won Byun, Ki-Hyun Baek, Ho Yeon Chung; J Bone Metab 2023;30(2):189-199.
Published online May 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.2.189

Background
This study aimed to evaluate the effectiveness of bazedoxifene/vitamin D combination therapy in preventing osteoporosis in postmenopausal women with osteopenia.
Methods
This was an open-label, multicenter randomized-controlled, phase 4 clinical trial. Women between ages of 55 and 70 years in 9 medical tertiary centers in Korea were enrolled and assigned into 2 groups: an experiment group and a control group. The experimental group received bazedoxifene 20 mg/vitamin D 800 IU tablets for 6 months, and the control group received calcium 100 mg/vitamin D 1,000 IU tablets for 6 months.
Results
A total of 142 patients (70 in the experimental group and 72 in the control group) were included. The least-square mean±standard error of change in propeptide of type I collagen after 3 months was -6.87±2.56% in the experimental group and 1.22±2.54% in the control group. After 6 months, it was -21.07±2.75% in the experimental group and 1.26±2.71% in the control group. The difference between the 2 groups was -22.33% (p<0.01). The change of C-terminal telopeptide was -12.55±4.05% in the experimental group and 11.02±4.03% in the control group after 3 months. It was -22.0±3.95% and 10.20±3.89, respectively, after 6 months. The difference between the 2 groups was -32.21% (p<0.01) after 6 months. There was no significant difference in adverse events between the 2 groups.
Conclusions
The osteoporosis preventive effect and safety of administering bazedoxifene/vitamin D combination pill were confirmed in postmenopausal women who needed osteoporosis prevention.

Citations

Citations to this article as recorded by

1. Role of vitamins in the development and treatment of osteoporosis (Review)
Mingze Jiang, Genghan Li, Keda Yang, Lin Tao
International Journal of Molecular Medicine.2025; 56(1): 1. CrossRef
2. Evaluation of the efficacy of combined vitamin D3 and K2 therapy in reducing implant-associated complication risk and improving spinal fusion stability
Oleksii S. Nekhlopochyn, Iryna G. Vasylieva, Nataliia G. Chopyk, Vadim V. Verbov, Ievgen V. Cheshuk, Milan V. Vorodi
Ukrainian Neurosurgical Journal.2025; 31(2): 10. CrossRef
3. Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines
Tomoyuki Asada, Soji Tani, Tomoko Towatari, Mahoko Ishikawa, Philip Varnadore, Yoshifumi Kudo, Peter G. Passias, Benjamin A. Alman, Koji Ishikawa
JOR SPINE.2025;[Epub] CrossRef
4. Molecular and Cellular Mechanisms of Osteoporosis
Ivan V. Zhivodernikov, Tatiana V. Kirichenko, Yuliya V. Markina, Anton Y. Postnov, Alexander M. Markin
International Journal of Molecular Sciences.2023; 24(21): 15772. CrossRef

4,921 View
107 Download
Crossref

Development and Validation of a New Clinical Diagnostic Screening Model for Osteoporosis in Postmenopausal Women: Jirapong Leeyaphan, Karn Rojjananukulpong, Piyapong Intarasompun, Yuthasak Peerakul; J Bone Metab 2023;30(2):179-188.
Published online May 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.2.179

Background
Age and weight are not only strong predictive parameters for osteoporosis diagnosis but can also be easily acquired from patients. This study aimed to develop and validate a new diagnostic screening model for postmenopausal osteoporosis that uses only 2 parameters, viz., age and weight. The discriminative ability of the model was analyzed and compared with that of the osteoporosis self-assessment tool for Asians (OSTA) index.
Methods
The age–weight diagnostic screening model was developed using a retrospective chart review of postmenopausal women aged ≥50 years who underwent dual energy X-ray absorptiometry at a tertiary hospital from November 2017 to April 2022. Logistic regression analysis was used to derive a diagnostic screening model for osteoporosis.
Results
A total of 533 postmenopausal women were included in the study. According to the highest Youden index value, a probability cut-off value of 0.298 was used in the diagnosis screening model at any site, which yielded a sensitivity of 84.3% and a specificity of 53.8%. For increased sensitivity as a screening tool, a cut-off value of 0.254 was proposed to obtain a sensitivity of 90.2% and a specificity of 42.2%. The area under receiver operating characteristic curves from all screening models were significantly higher than those from the OSTA index model (p<0.05).
Conclusions
This study showed the feasibility of a postmenopausal osteoporosis diagnostic screening model that uses 2 strong predictors for osteoporosis diagnosis: age and weight. This age–weight diagnostic model is a simple, effective option in postmenopausal osteoporosis screening.

Citations

Citations to this article as recorded by

1. Performance of clinical prediction models for identifying postmenopausal osteoporosis: a systematic review and meta-analysis
Xinyi Huang, Yiwen Gan, Xiangyun Guo, Yunning Li, Liang Wang, Jinran Qin, Chuanrui Sun, Yuhui Yin, Ming Chen, Yanming Xie, Yang Guo, Xu Wei, Yili Zhang
BMC Musculoskeletal Disorders.2026;[Epub] CrossRef
2. Simple clinical predictors for making directive decisions in osteoporosis screening for women: a cross-sectional study
Jirapong Leeyaphan, Karn Rojjananukulpong, Piyapong Intarasompun, Yuthasak Peerakul
Journal of Orthopaedic Surgery and Research.2024;[Epub] CrossRef

4,614 View
100 Download
Crossref

Bone Mineral Density, Trabecular Bone Score and Fractures in Patients Hospitalized for Heart Failure: Lucian Batista de Oliveira, Mariana Andrade de Figueiredo Martins Siqueira, Rafael Buarque de Macedo Gadêlha, Beatriz Pontes Barreto, Alice Rodrigues Pimentel Correia, Vinicius Belfort Leão, Jessica Garcia, Francisco Bandeira; J Bone Metab 2023;30(2):167-177.
Published online May 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.2.167

Background
This study aimed to evaluate the bone mineral density (BMD), trabecular bone score (TBS), and fracture history of middle-aged patients hospitalized for heart failure (HF), as well as analyze the association of these factors with cardiometabolic parameters and muscle strength.
Methods
A cross-sectional study with patients aged 40 to 64 years hospitalized for HF was performed. Dual energy X-ray absorptiometry was performed to obtain BMD and TBS. Fracture history, handgrip strength (HGS), and clinical and laboratory cardiometabolic parameters of the patients were evaluated.
Results
Altogether, 109 patients were evaluated (female 50.5%). Medians and interquartile ranges for age and length of hospital stay were 58.0 (53.0–61.0) years and 20.0 (11.0–32.0) days, respectively. Osteoporosis was observed in 15.6% of the patients, low TBS was observed in 22.8%, and 6 patients had a history of fragile fracture. No differences between the sexes regarding BMD (p=0.335) or TBS (p=0.736) classifications were observed. No association was observed between low BMD and HF classification (p>0.05) regarding the ejection fraction, ischemic etiology, or New York Heart Association Functional Classification. However, there was a significant association between high serum parathyroid hormone (PTH) and the presence of osteoporosis (62.5 [37.2–119.0] pg/mL vs. 34.2 [25.0–54.1] pg/mL; p=0.016). There was a negative correlation between serum PTH and TBS (r=−0.329, p=0.038) and a higher frequency of reduced HGS in patients with low TBS (92.3% vs. 50.0%; p=0.009).
Conclusions
We found relevant frequencies of osteoporosis and bone microarchitecture degradation in middle-aged patients with HF, which were related to high serum PTH concentrations.

Citations

Citations to this article as recorded by

1. Cellular alterations in trabecular bone following monocrotaline-induced right heart failure in rats
Akinori Kaneguchi, Rena Takagi, Sakura Sunagawa, Yuichiro Azuma, Koki Ishinaka, Takuya Umehara, Kaoru Yamaoka, Junya Ozawa
Bone.2026; 205: 117807. CrossRef

5,083 View
102 Download
Crossref

Position Statement: Exercise Guidelines for Osteoporosis Management and Fall Prevention in Osteoporosis Patients: Seongryu Bae, Seungyong Lee, Hyuntae Park, Yongin Ju, Seok-Ki Min, Jinkyung Cho, Hyojin Kim, Yong-Chan Ha, Yumie Rhee, Young-Pyo Kim, Changsun Kim; J Bone Metab 2023;30(2):149-165.
Published online May 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.2.149

Background
The effectiveness of exercise for improving osteoporosis and fall prevention in patients diagnosed with osteoporosis or osteopenia has not been fully summarized. The Korean Society for Bone and Mineral Research and the Korean Society of Exercise Physiology has developed exercise guidelines for patients with osteoporosis or osteopenia and provide evidence-based recommendations.
Methods
A systematic review identified randomized controlled trials (RCT) assessing the effect of resistance, impact, balance, aerobic training, and physical activity in osteoporosis and osteopenia on bone quality, physical performance, quality of life, and fall prevention. PubMed, Embase, KoreaMed, and RISS were searched from January 2000 to August 2022. Ten key questions were established to review the evidence and formulate recommendations.
Results
The 50 RCTs reported that even with osteoporosis and osteopenia, resistance and impact training consistently maximized bone strength, improved body strength and balance, and eventually reduced fall incidences. Resistance exercise combining 3 to 10 types of free weight and mechanical exercise of major muscle groups performed with an intensity of 50% to 85% 1-repetition maximum, 5 to 12 repetitions/set, 2 to 3 days/week, for 3 to 12 months is recommended. Impact exercises such as jumping chin-ups with drop landings and jump rope performed 50 jumps/session for at least 6 months with 3 or more days/week are recommended.
Conclusions
A multi-component exercise mainly comprised of resistance and impact exercise seems to be an effective strategy to attenuate the risk factors of osteoporosis and osteopenia. The integration of exercise guidelines and individualized exercise plans has significant potential to reduce the morbidity and mortality of osteoporosis.

Citations

Citations to this article as recorded by

1. Promoting and impeding factors for exercise in patients with osteopenia or osteoporosis: A systematic review
Yi Liu, Chenxin Zhang, Liping Zhang, Xian Ma, Zhenghui Dong
International Journal of Nursing Studies Advances.2026; 10: 100456. CrossRef
2. Effects of exercise on the cortical bone of the proximal femur in women: a systematic review and meta-analysis
Norifumi Fujii, Takeshi Imura, Tsubasa Mitsutake, Kenta Hirohama, Nobukazu Okimoto, Manabu Tsukamoto, Ryo Tanaka
Bone.2026; 203: 117740. CrossRef
3. High prevalence of low bone mineral density in wheelchair users regardless of sports participation: a cross-sectional analysis of the bonewheel study
Linn C. Risvang, Jan-Willem van Dijk, Julia K. Baumgart, Hannah M. Rice, Anja M. F. Liljegren, Vegard Strøm, Truls Raastad, Kristin L. Jonvik
European Journal of Applied Physiology.2026; 126(5): 2879. CrossRef
4. Guía de Práctica Clínica multidisciplinaria para la osteoporosis en Colombia: recomendaciones basadas en la evidencia y adaptadas al contexto nacional
Geraldine Altamar-Canales, Daniel G. Fernández-Ávila, Miguel Ángel González-Reyes, Francisco Bernardo Linares-Restrepo, Adriana Medina-Orjuela, Francisco Oscar Fernando Rosero-Olarte, Javier Armando Velásquez-Mendoza, Ximena Castro-Flórez, Edgar Eduardo C
Revista Colombiana de Reumatología.2026; 33(2): 504840. CrossRef
5. The relationship between muscle strength, balance and falls in elderly postmenopausal osteoporosis patients
Funda Datlı Yakaryılmaz, Aslıhan Mete Yıldırım, Zeynel Abidin Öztürk
Journal of Clinical Densitometry.2026; 29(2): 101682. CrossRef
6. Current Perspectives on Exercise for Osteoporosis Prevention in Korean Older Adults: A Scoping Review regarding Mechanisms, Interventions, and Clinical Implications
Ji-Sik An, Wi-Young So
The Asian Journal of Kinesiology.2026; 28(1): 88. CrossRef
7. Multimodal high-intensity gymnastics induced marked osteogenic impact for postmenopausal women
Eva W. HELGE, Michael T. LUND, Mogens T. PEDERSEN, Sofie G. VESTERGAARD, Carina A. SØNDERGAARD, Simon ESRUP, Magnus BENDTSEN, Anders O. MADSEN, Anette BUNDGAARD, Nadia QUARDON, Niklas R. JØRGENSEN
The Journal of Sports Medicine and Physical Fitness.2026;[Epub] CrossRef
8. Mechanisms of green tea-induced attenuation of osteoporosis and skeletal muscle atrophy: current status and future study recommendations for clinical application
Youngjoo Kwon
Critical Reviews in Food Science and Nutrition.2026; : 1. CrossRef
9. Effects of a 12-week time-of-day-specific concurrent resistance-aerobic training on muscle strength, bone mass and functional performance in elderly women
Gabriela Šašovová, Barbora Kundeková, Ľudmila Oreská, Michal Střelecký, Milan Sedliak, Monika Okuliarová, Michal Zeman, Zdenko Kilinger, Juraj Payer, Viktor Oliva
European Journal of Translational Myology.2026;[Epub] CrossRef
10. The impact of Tai Chi on osteoporosis and osteopenia in middle-aged and elderly adults: a systematic review and meta-analysis of randomized controlled trial
Xiude Guo, Jieping Wang, Yi Wang, Qin Sun
Osteoporosis International.2026;[Epub] CrossRef
11. The impact of high-intensity interval training interventions on adult's bone mineral density and bone turnover markers: A systematic review and meta-analysis
X. Wang, Z. Geng, Z. Pan
Science & Sports.2026; 41(4): 298. CrossRef
12. Comparative efficacy of different traditional Chinese exercises on bone mineral density in older adults: a systematic review and network meta-analysis
Mingxuan Hou, Siqi Jin, Jiaxin Luo, Ling Yang
Osteoporosis International.2026;[Epub] CrossRef
13. Analysis of risk factors and development of a predictive model for new vertebral fractures subsequent to percutaneous kyphoplasty in patients with single-segment osteoporotic vertebral compression fractures
Fumai Zhang, Jiayi Chen, Guang Li, Bin Wu, Wentao Cai
BMC Musculoskeletal Disorders.2026;[Epub] CrossRef
14. Association of walking and osteoporosis risk among 432,493 UK participants: A prospective cohort study
Zhehan Yang, Donglin Luo, Haichao Jiang, Yahai Wang, Haixia Qi
Public Health.2026; 256: 106308. CrossRef
15. Multidisciplinary clinical practice guideline for osteoporosis in Colombia: Evidence-based recommendations adapted to the national context
Geraldine Altamar-Canales, Daniel G. Fernández-Ávila, Miguel Ángel González-Reyes, Francisco Bernardo Linares-Restrepo, Adriana Medina-Orjuela, Francisco Oscar Fernando Rosero-Olarte, Javier Armando Velásquez-Mendoza, Ximena Castro-Flórez, Edgar Eduardo C
Revista Colombiana de Reumatología (English Edition).2026; 33(2): 504840. CrossRef
16. Diagnosis and treatment of osteoporosis: 2026 recommendations of the Polish Society for Rheumatology
Piotr Leszczyński, Cezary Iwaszkiewicz, Zbigniew Michał Żuber, Brygida Kwiatkowska, Bogdan Piotr Batko, Katarzyna Krystyna Pawlak-Buś
Rheumatology.2026;[Epub] CrossRef
17. Polymyalgia rheumatica in a patient presenting with persisting bilateral buttock pain - a case report
Rohil Chauhan, Anand Segar, William Boissonnault
Physiotherapy Theory and Practice.2025; 41(5): 1124. CrossRef
18. Rehabilitative good clinical practice in the treatment of osteoporosis: a comprehensive review of clinical evidences
Francesco Agostini, Alessandro de Sire, Valerio Sveva, Nikolaos Finamore, Alessio Savina, Andrea Fisicaro, Andrea Bernetti, Valter Santilli, Massimiliano Mangone, Marco Paoloni
Disability and Rehabilitation.2025; 47(16): 4010. CrossRef
19. Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis
Jingyuan Wei, Qi Liu, Ho-Yin Yuen, Avery Chik-Him Lam, Yuanyuan Jiang, Yuhe Yang, Yaxiong Liu, Xin Zhao, Long Xiao
Journal of Orthopaedic Translation.2025; 50: 373. CrossRef
20. Osteoporosis Evaluation by Radiofrequency Echographic Multispectrometry (REMS) in Primary Healthcare
Ana Vieira, Rute Santos
Diagnostics.2025; 15(7): 808. CrossRef
21. Investigating the Effects of a High-Load Resistance Training Program on Bone Health in Wheelchair Users (the BoneWheel Study): Protocol for a Randomized Controlled Trial
Linn Christin Risvang, Vegard Strøm, Jan-Willem van Dijk, Hannah Rice, Øyvind Sandbakk, Lars Peder Bovim, Julia Kathrin Baumgart, Marte Bentzen, Truls Raastad, Kristin L Jonvik
JMIR Research Protocols.2025; 14: e70125. CrossRef
22. Optimal resistance training parameters for improving bone mineral density in postmenopausal women: a systematic review and meta-analysis
Fang Zhao, Wenbo Su, Yaowei Sun, Jing Wang, Bin Lu, Hezhang Yun
Journal of Orthopaedic Surgery and Research.2025;[Epub] CrossRef
23. Culturally Adapted, Clinician-Led, Bilingual Group Exercise Program for Older Migrant Adults: Single-Arm Pre–Post-Intervention
Morwenna Kirwan, Christine L. Chiu, Jonathon Fermanis, Katie Allison, Thomas Laing, Kylie Gwynne
International Journal of Environmental Research and Public Health.2025; 22(6): 888. CrossRef
24. Engagement in Ageless Gym Programs Among Older Adults in Rural Communities: A Retrospective Study on Relationships With Age, Health Conditions, and Proximity to Health Facilities
Hung-Pin Chen, Yen-Po Yeh, Dih-Ling Luh, Sonu Bhaskar
Journal of Aging Research.2025;[Epub] CrossRef
25. Geriatric fractures presenting to emergency departments in the United States: an epidemiologic analysis of national injury data from 2019 to 2023
Niklas H. Koehne, Auston R. Locke, Charu Jain, Nikan K. Namiri, Avanish Yendluri, Jeremy Podolnick, Scott Ryan, David A. Forsh, Lisa K. Cannada, Robert L. Parisien
Injury.2025; 56(8): 112550. CrossRef
26. The Effects of Soy Isoflavone Genistein Administration on Bone Mineral Density in Elderly and Super-elderly Women: A Randomized, Placebo-controlled, Double-blind Pilot Study
Changsun Kim
Journal of The Korean Society of Living Environmental System.2025; 32(3): 314. CrossRef
27. Effectiveness of an mHealth-based impact exercise program for bone health in postmenopausal women: a randomised controlled trial protocol
Borja Sañudo, Gonzalo Reverte-Pagola, Carol Maher, Job Godino, Luis Carrasco, Miguel Ángel Oviedo, Adrián Feria, Horacio Sánchez-Trigo, Hugo Gamboa, Raquel Domingo-Molina, Alejandro Sánchez-Arteaga, Miguel Ángel Giráldez, Mª Ángeles Martínez-Maestre, Elen
BMC Public Health.2025;[Epub] CrossRef
28. Is YouTube a Reliable Resource for Osteoporosis Exercise Guidance? A Descriptive Cross-sectional Study
Serpil Çelik, Elif Tarihçi Çakmak
Turkish Journal of Osteoporosis.2025;[Epub] CrossRef
29. Rheuma bewegt – Eine Verortung der Sport- und Bewegungstherapie bei chronisch entzündlich-rheumatischen Erkrankungen
Matthias Dreher, Maximilian Köppel, Freerk T. Baumann, Christoph Biehl, Andreas Schwarting
Zeitschrift für Rheumatologie.2025; 84(6): 425. CrossRef
30. Impact of social determinants of health on mortality risk in older adults with osteopenia or osteoporosis
Mingzhen Yang, Ping Wang, Guanghua Liu, Mingfang Shi, Ruijun Xue, Yuanyuan Liu, Bangzhong Liu
Experimental Gerontology.2025; 210: 112871. CrossRef
31. Educational interventions on falls and fracture prevention in community dwelling older adults: a scoping review
Hiromi Matsumoto, Yuki Kitsuda, Takashi Wada
Gerontology & Geriatrics Education.2025; : 1. CrossRef
32. The effects of Sitting Baduanjin intervention based on the COM-B model for elderly patients with osteoporosis after vertebroplasty: A randomized controlled trial
Lidan Yang, Fang Lu, Jing Chen, Jiali Wu, Jia Li, Jiangtao OuYang, Can Zheng, Jingbei Zhang, Xujuan Zheng
Complementary Therapies in Medicine.2025; 95: 103275. CrossRef
33. Unilateral biportal endoscopic decompression for two-level adjacent lumbar spinal stenosis through a single sliding approach: technical report and early follow-up
Shuang Xu, Heng Wu, Hao Liu, Junwei Xiang, Jin Yang, Chuanen Wang, Song Wang
Journal of Orthopaedic Surgery and Research.2025;[Epub] CrossRef
34. Avaliação e prescrição de exercícios físicos para grupos especiais (osteoporose)
Ramom Vieira de Oliveira, Matheus Souza Martins, Valter Paulo Neves Miranda
Cuadernos de Educación y Desarrollo.2025; 17(12): e10425. CrossRef
35. Effect of a Low-Intensity Combined Exercise Program using Props on the Daily Living Fitness and Quality of Life of Elderly Women
Hong-Gyun Lee, Eun-Jeong Kim
Journal of The Korean Society of Physical Medicine.2024; 19(1): 119. CrossRef
36. Protective role of exercise on breast cancer-related osteoporosis in women undergoing aromatase inhibitors: A narrative review
Claudia Cerulli, Elisa Moretti, Elisa Grazioli, Gian Pietro Emerenziani, Arianna Murri, Eliana Tranchita, Carlo Minganti, Alessandra Di Cagno, Attilio Parisi
Bone Reports.2024; 21: 101756. CrossRef
37. Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives
Yumei Liao, Aihong Wang, Wenjuan Sui, Abbas Khan, Zibo Xiong, Guang Yang
Nursing: Research and Reviews.2024; Volume 14: 69. CrossRef
38. Beyond Bone: Embracing Osteosarcopenia for Comprehensive Fracture Prevention
Beom-Jun Kim
Endocrinology and Metabolism.2024; 39(3): 531. CrossRef
39. The Effects and Risk Factors of Femoral Neck Shortening after Internal Fixation of Femoral Neck Fractures
Dae Hee Lee, Joo Han Kwon, Ki-Choul Kim
Clinics in Orthopedic Surgery.2024; 16(5): 718. CrossRef
40. Regular physical activity improves physical function and health-related quality of life among middle-aged and older women who suffered a fragility fracture—a population-based cohort
Anabela Barcelos, David G. Lopes, Carolina Mazeda, Helena Canhão, Jaime da Cunha Branco, Ana Maria Rodrigues
Osteoporosis International.2024; 35(12): 2203. CrossRef
41. Biomechanical Analysis of Injury Risk in Two High-Altitude Landing Positions Using Xsens Inertial Units and EMG Sensors
Xuewu Yao, Haojie Li, Chen Xiu
Sensors.2024; 24(21): 6822. CrossRef
42. Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health
Daniel Vasile Timofte, Razvan Cosmin Tudor, Veronica Mocanu, Luminita Labusca
Nutrients.2024; 16(23): 4231. CrossRef
43. Osteoporosis: Causes, Mechanisms, Treatment and Prevention: Role of Dietary Compounds
Kristine Stromsnes, Cristian Martinez Fajardo, Silvana Soto-Rodriguez, Erika Ria Ulrika Kajander, Remus-Iulian Lupu, Monica Pozo-Rodriguez, Balma Boira-Nacher, Maria Font-Alberich, Marcos Gambini-Castell, Gloria Olaso-Gonzalez, Maria-Carmen Gomez-Cabrera,
Pharmaceuticals.2024; 17(12): 1697. CrossRef

18,266 View
757 Download
Crossref

Review Article

Effect of Vitamin B6 on Osteoporosis Fracture: Rahmani Welan; J Bone Metab 2023;30(2):141-147.
Published online May 31, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.2.141

Osteoporosis is a medical condition that causes bones to become weak and brittle, making them more likely to break or fracture. This condition occurs when the body loses too much bone, makes too little bone, or both. Bones are living tissues that are constantly being broken down and rebuilt. However, as we age, this process slows down, and our bodies may be unable to replace bone as quickly as it is broken down. This can lead to a loss of bone density, making bones weaker and more prone to fracture. Unfortunately, osteoporosis often has no symptoms until a bone is broken, so taking steps to prevent this condition is essential. This may include getting enough calcium and vitamin D, engaging in weight-bearing exercise, quitting smoking, limiting alcohol intake, and taking medication if prescribed by a doctor. Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that plays a vital role in various bodily functions. It is part of the B-vitamin complex and is essential for metabolizing proteins, carbohydrates, and fats. Vitamin B6 produces neurotransmitters such as serotonin, which helps regulate mood, and dopamine, which is involved in motivation and reward. Several previous studies have found that women with higher intakes of vitamin B6 have higher bone mineral density (BMD) of the hips and spine than women with lower intakes. Another study found that men and women with higher blood levels of vitamin B6 had higher BMD in the hips and spine.

Citations

Citations to this article as recorded by

1. SuperLearner approach for predicting imminent risk of fracture in older Chinese patients with newly diagnosed osteoporosis based on their routine blood test markers
Bailu Chen, Jinshan Zhang, Yangzhen Fang, Chao Liu, Ming Chen
BMC Musculoskeletal Disorders.2026;[Epub] CrossRef
2. Expert opinion on the role of Calcium–Magnesium synergy in osteoporosis care
Roshan Wade, Santosh Shetty, Miten Sheth, Rajkumar S. Amrawati, Anand Galagali, P. Gopinathan, Sanjay Londhe, Ravinder Lamoria, Prashant Tonape, Sumit Banerjee, Satish Sonar
Journal of Orthopaedic Reports.2026; : 101032. CrossRef
3. A comprehensive review and advanced biomolecule-based therapies for osteoporosis
Maqsood Ali, Yong-Sik Kim
Journal of Advanced Research.2025; 71: 337. CrossRef
4. Black Barley Grain and Its Processing By-Product as a Potential Raw Material for Functional Food
Karolina Błaszczyk, Małgorzata Szczepanek, Rafał Nowak, Kinga Stuper Szablewska, Ersilia Călina Alexa, Georgeta Pop
Food and Bioprocess Technology.2025; 18(5): 4859. CrossRef
5. Role of vitamins in the development and treatment of osteoporosis (Review)
Mingze Jiang, Genghan Li, Keda Yang, Lin Tao
International Journal of Molecular Medicine.2025; 56(1): 1. CrossRef
6. Functional benefits of ultra‑high hydrostatic pressurized brown rice on cognition, apathy, and bone health in older adults: A 12‑month randomized controlled trial
Kentaro Matsuzaki, Shozo Yano, Yoko Kuroda, Hiroko Nakahata, Tatsushi Matsuda, Hitoshi Kinoshita, Katsumi Yoshino, Osamu Shido, Hiroko Kishi, Michio Hashimoto
Experimental and Therapeutic Medicine.2025; 30(4): 1. CrossRef
7. Nonlinear dose-response relationship between dietary niacin intake and osteoporosis in U.S. adults over 50 years of age: a cross-sectional study of the 2007-2018 National Health and Nutrition Examination Survey (NHANES)
Jia Bai, Botao Gao, Jinyang An, Lingling Li, Yangyang Zhang, Xinsai Li, Shuyun Li, Haihong Lv
Nutrición Hospitalaria.2025;[Epub] CrossRef
8. Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review
Norihisa Kato, Akiko Kimoto, Peipei Zhang, Chanikan Bumrungkit, Sajith Karunaratne, Noriyuki Yanaka, Thanutchaporn Kumrungsee
Nutrients.2024; 16(1): 177. CrossRef
9. Changes in bone turnover markers 6–12 months after bariatric surgery
Per G. Farup
Scientific Reports.2024;[Epub] CrossRef
10. Associations of oxidative balance score with lumbar spine osteopenia in 20–40 years adults: NHANES 2011–2018
Yu-Ao Tao, Ling Long, Jia-Xiang Gu, Pei-Yang Wang, Xi Li, Xiao-Long Li, Pan Fan, Yuntao Wang
European Spine Journal.2024; 33(9): 3343. CrossRef
11. The Association Between Tuberculosis and Osteoporosis: A Systematic Review and Meta-Analysis
Kridh Charatcharoenwitthaya, Kajorn Suntrapiwat, Wasit Wongtrakul
Cureus.2024;[Epub] CrossRef

6,176 View
113 Download
Crossref

Original Articles

Different Pattern of T-Score Discordance between Patients with Atypical Femoral Fracture and Femur Neck Fracture: Byung-Ho Yoon, Jang-Won Park, Chan Woo Lee, Young Do Koh; J Bone Metab 2023;30(1):87-92.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.87

Background
Our study evaluated the prevalence and pattern of T-score discordance between the spine and hip in Korean patients with atypical femoral fracture (AFF) and femur neck fracture (FNF).
Methods
A total of 49 patients (all women) who were treated for AFF and 1:3 matched 147 female patients with FNF were included from January 2012 to August 2022. A discordance of more than 1.5 between lumbar spine and femur neck bone mineral density (BMD) was defined as a difference and divided into 3 groups: lumbar low (LL; lumbar BMD is less than femur neck BMD), no discordance (ND), and femur neck low (FL; femur neck BMD is less than lumbar BMD). We compared the prevalence and pattern of discordance between 2 groups, and the associated risk factors of T-score discordance among the subjects were evaluated using regression analysis.
Results
The prevalence of discordance was significantly higher in patients with AFF (51%) than in those with FNF (25.2%; p<0.001). LL discordance was found in 46.9% of the patients with AFF but only 4.8% in those with FNF. Conversely, FL discordance was found in 4.1% of the patients with AFF and 20.4% in those with FNF, respectively. No specific risk factor was found as T-score discordance in the 2 groups.
Conclusions
Clinicians should be aware that the pattern of T-score discordance can vary depending on the location of osteoporotic fractures. In addition, a longitudinal study would be necessary to verify the pattern of T-score discordance related to the osteoporotic fracture location.

Citations

Citations to this article as recorded by

1. Association between decreased bone mineral density and Pauwels angle in femoral neck fractures: a cross-sectional study
Soo-Hwan Jung, Yong-Uk Kwon, Ji-Hun Park
Journal of Musculoskeletal Trauma.2026; 39(1): 20. CrossRef
2. Development of AI model for dual detection of low bone mineral density in the femoral neck and lumbar vertebrae using chest radiographs
Yukino Ohta, Kouichi Yamamoto, Yutaka Katayama, Takahiro Ideta, Hiroaki Matsuzawa, Takao Ichida, Akane Utsunomiya, Takayuki Ishida
Journal of Clinical Densitometry.2025; 28(4): 101604. CrossRef
3. Factors Associated with Discordance between Hip and Spine Bone Mineral Density
Weon Kim, Min Kyu Choi
Korean Journal of Family Practice.2025; 15(3): 167. CrossRef

4,725 View
80 Download
Crossref

Trabecular Bone Score and Central Quantitative Computed Tomography for the Prediction of Vertebral Fragility Fractures in Postmenopausal Women: Soree Ryang, Yun Kyung Jeon, Tae Sik Goh, In-Joo Kim, Keunyoung Kim; J Bone Metab 2023;30(1):77-86.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.77

Background
We aimed to investigate whether densitometry results and volumetric bone mineral density (vBMD) can predict vertebral fragility fractures (VFF) in postmenopausal women.
Methods
We enrolled 271 postmenopausal women aged >45 years who visited our hospital for health check-ups between September 2016 and September 2017. The lumbar spine (LS) and femoral neck (FN) densitometry results and trabecular bone score (TBS) were calculated using dual energy X-ray absorptiometry. vBMD was assessed using central quantitative computed tomography (cQCT). Baseline and follow-up X-ray images were reviewed to evaluate thoracolumbar vertebral compression fractures (CFs), according to the Genant criteria.
Results
At baseline, 76 patients (28.0%) had CF. Additional or progressive fractures were noted in 26 participants (9.6%) with a median follow-up of 19.5 months. The median TBS and cQCT were significantly higher in participants without baseline CF than those with baseline CF (p<0.001). During the follow-up, Kaplan–Meier analysis showed that T-scores of the LS and FN <-2.5, degraded microarchitecture based on the TBS (≤1.200), and vBMD <80 mg/cm3 was significantly associated with future osteoporotic CF. The final multivariate Cox regression analysis showed that baseline CF and low TBS and vBMD were significant risk factors for future VFF.
Conclusions
Participants with baseline CF and degraded microarchitecture had higher CF predisposition. Moreover, cQCT can predict future vertebral fractures.

Citations

Citations to this article as recorded by

1. Assessment of trabecular bone score (TBS) in the prediction of vertebral fracture in postmenopausal osteoporosis
Federica Biamonte, Jessica Pepe, Luciano Colangelo, Giovambattista Desideri, Evaristo Ettorre, Luciano Nieddu, Davide Diacinti, Daniele Diacinti, Salvatore Minisola, Cristiana Cipriani
Bone.2025; 190: 117307. CrossRef
2. Functional outcomes following hip fracture with concurrent vertebral fracture within a fracture liaison service
Ong-art Phruetthiphat, Wasin Kanokwongnuwat, Yodhathai Satravaha, Panukorn Pinijprapa, Chaisiri Chaichankul, Pawin Gajaseni
Scientific Reports.2025;[Epub] CrossRef
3. TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT
E. M. F. Gama, L. M. C. Mendonça, F. P. Paranhos-Neto, L. Vieira Neto, M. Madeira, M. L. F. Farias
Journal of Bone and Mineral Metabolism.2024; 42(3): 352. CrossRef
4. Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study
Tingxiao Zhao, Yanlei Li, Jinlong Tian, Yao Kang, Jiongnan Xu, Haiyu Shao, Jinlei Zhou, Chen Xia, Yongguang Wang, Jun Zhang
Scientific Reports.2024;[Epub] CrossRef
5. Development and validation of a predictive model for vertebral fracture risk in osteoporosis patients
Jun Zhang, Liang Xia, Xueli Zhang, Jiayi Liu, Jun Tang, Jianguo Xia, Yongkang Liu, Weixiao Zhang, Zhipeng Liang, Guangyu Tang, Lin Zhang
European Spine Journal.2024; 33(8): 3242. CrossRef
6. Comparative effectiveness of four techniques for identifying vertebral fragility fractures among elderly patients
Hui-Ya Ma, Ren-Jie Zhang, Lu-Ping Zhou, Yan-Xin Wang, Jia-Qi Wang, Cai-Liang Shen, Xiu-Jun Zhang
European Radiology.2024; 35(6): 3673. CrossRef

4,815 View
102 Download
Crossref

Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry: Hasan M. Isa, Amira A. Ezzaldin, Mohamed M. Alabbasi, Noora H. ALaazmi, Abdulrahman S. Masood, Hissa M. Alabbasi; J Bone Metab 2023;30(1):59-68.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.59

Background
Inflammatory bowel disease (IBD) is a chronic inflammatory immune-mediated condition that affects the gastrointestinal system and alters bone growth and bone mineral density (BMD). Here we aimed to study the prevalence and predictors of a low BMD in pediatric patients with IBD.
Methods
This retrospective cross-sectional analytical study included pediatric patients with IBD in whom BMD was evaluated using dual energy X-ray absorptiometry of the total body and lumbar spine. Osteoporosis was defined as a BMD Z-score ≤-2, osteopenia as -2 to -1, and normal as >-1. Clinical and laboratory findings were compared between patients with and without osteoporosis.
Results
Of the 48 patients, 30 (62.5%) were males, 35 (72.9%) had Crohn’s disease, and 13 (27.1%) had ulcerative colitis. The mean age at diagnosis was 9.9±2.8 years. The median age at the time of the BMD scans was 11.9 (interquartile range, 9.9–14.3) years. Total body BMD scans identified 13 (27.1%) and 16 (33.3%) patients with osteoporosis and osteopenia, respectively. Spinal BMD scans revealed that 17 (39.5%) and 14 (32.6%) patients had osteoporosis and osteopenia, respectively. A low body mass index (BMI) Z-score (p=0.038), ileocolonic disease location (p=0.008), and a low calcium level (p=0.008) were significant predictors of osteoporosis on the total body BMD scans. A low BMI Z-score (p=0.039), decreased hemoglobin level (p=0.018), low calcium level (p=0.033), and infliximab use (p=0.019) were significant predictors of osteoporosis on the spinal BMD scans.
Conclusions
This study showed a high prevalence of low BMD among pediatric patients with IBD. A low BMI, ileocolonic disease location, low hemoglobin and calcium levels, and infliximab use were significantly associated with osteoporosis.

Citations

Citations to this article as recorded by

1. Decreased Bone Mineralization in Children with Inflammatory Bowel Diseases
M. I. Erokhina, N. D. Odinaeva, E. I. Kondratуeva, A. I. Khavkin, E. A. Yablokova, E. K. Zhekaite
Russian Journal of Gastroenterology, Hepatology, Coloproctology.2026; 35(6): 72. CrossRef
2. Factors associated with low bone mineral density at diagnosis in pediatric Crohn’s disease: a large retrospective cohort study
Hansol Kim, Yoon Zi Kim, Seon Young Kim, Yon Ho Choe, Mi Jin Kim
BMC Gastroenterology.2026;[Epub] CrossRef
3. Mendelian randomization analysis to identify potential drug targets for osteoarthritis
Chengyang Lu, Yanan Xu, Shuai Chen, Li Guo, Pengcui Li, Xiaochun Wei, Xueqin Rong, Stephan N. Witt
PLOS ONE.2025; 20(2): e0316824. CrossRef
4. Bone Health in Paediatric Inflammatory Bowel Disease
Proteek Sen, Suma Uday
Diagnostics.2025; 15(5): 580. CrossRef
5. Bone-Specific Alkaline Phosphatase as a Complementary Diagnostic Marker for the Assessment of Children and Adolescents with Secondary Osteoporosis
Eunha Bae, Soo Yeun Sim, Su Jin Park, Sung Eun Kim, Seulki Kim, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh, Moon Bae Ahn
Diagnostics.2025; 15(5): 630. CrossRef
6. Pediatric inflammatory bowel disease in patients of Middle Eastern descent seen at a large urban children's hospital
Renee Dass, Gillian Greenberg, Ronald Thomas, Kirsten Cares
Journal of Pediatric Gastroenterology and Nutrition.2025; 81(3): 583. CrossRef
7. Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease
Shilpa Sharma
Intestinal Research.2025; 23(3): 254. CrossRef
8. Genetic variants of MTHFR gene in relation to folic acid levels and bone mineral density in Polish patients with inflammatory bowel disease
Alicja E. Ratajczak-Pawłowska, Szymon Hryhorowicz, Aleksandra Szymczak-Tomczak, Ewa Wysocka, Michał Michalak, Marta Kaczmarek-Ryś, Emilia Lis-Tanaś, Lena Bielawska, Andrzej Pławski, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Journal of Applied Genetics.2024; 65(1): 73. CrossRef
9. Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility
Sung Eun Kim, Seulki Kim, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Moon Bae Ahn
Biomedicines.2024; 12(6): 1173. CrossRef
10. The Prevalence of Iron and Vitamin D Deficiencies in Pediatric Patients With Inflammatory Bowel Disease in Bahrain
Hasan M Isa, Fawzeya A Alahmed, Masooma Mohamed, Afaf Mohamed
Cureus.2023;[Epub] CrossRef

5,930 View
104 Download
Crossref

Best Laboratory Screening in Diagnosing Secondary Osteoporosis and Fracture Risk Assessment Tool and the National Osteoporosis Guideline Group Performance in Determining Clinical Risk: A Cross-Sectional Evaluation of the Bone Health in Postmenopausal Brazilian Women: Marcelo Luis Steiner, Gabriela Polvani Crotti, Juliana Daltrino Teodoro, Raissa Kaori Ikeda, Rodolfo Strufaldi, César Eduardo Fernandes, Luciano de Melo Pompei; J Bone Metab 2023;30(1):47-57.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.47

Background
Identifying postmenopausal women with a high risk of having osteoporosis and fractures is a current challenge. This study aimed to assess the diagnostic performance of biochemical tests in identifying secondary osteoporosis and the fracture risk assessment tool (FRAX) in identifying fracture risk.
Methods
Data from biochemical tests and bone densitometry of postmenopausal women were analyzed. Additionally, the FRAX result was obtained and the patients were classified according to the National Osteoporosis Guideline Group (NOGG).
Results
A total of 646 women were evaluated, of whom 201 (31.1%) had osteoporosis or a previous frailty fracture. These women had statistically different parathyroid hormone (PTH) and alkaline phosphatase serum levels (p<0.01 and p=0.02, respectively) than those without osteoporosis or fracture. However, those at high risk had a higher prevalence of hypovitaminosis D (46% vs. 36%) and hypocalciuria (17% vs. 9%). The FRAX showed an area under the curve of 0.757 (p<0.01) and 0.788 (p<0.01) for identifying women at risk for “major fractures” and “hip,” respectively. The NOGG categorization had a sensitivity of 19% to identify high-risk women, a specificity of 91.3% for low-risk women, with a positive predictive value of 57.4% and a negative predictive value of 64.6%.
Conclusions
The evaluation of PTH, 25-hydroxy-vitamin D, serum calcium, and 24-hr urinary calcium proved adequate for initial osteoporosis screening. The FRAX tool has a regular ability to screen women at risk for fracture, and the NOGG method has high specificity to identify those at low risk.

5,028 View
123 Download

Health-Related Quality of Life in Osteoporosis Patients with and without Fractures in Tehran, Iran: Marziyeh Rajabi, Afshin Ostovar, Ali Akbari Sari, Sayed Mahmoud Sajjadi-Jazi, Abdoreza Mousavi, Bagher Larijani, Noushin Fahimfar, Rajabali Daroudi; J Bone Metab 2023;30(1):37-46.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.37

Background
This study aimed to measure the health-related quality of life (HRQOL) of patients with osteoporosis with and without fractures in Tehran, the capital city of Iran.
Methods
We surveyed a sample of 478 patients with osteoporosis aged over 50 years. Participants with fractures included patients referred to hospitals due to osteoporotic fractures which were alive 6 months after the fracture. Participants without fractures were randomly selected from patients with a definite diagnosis of osteoporosis admitted to 3 outpatient clinics in Tehran. Data were collected using the EuroQol 5-dimensional 5-level questionnaire. Statistical differences between patients with and without fracture were tested with Pearson’s χ² test, Student’s t-test, and the Mann–Whitney U-test. The association between HRQOL and other variables was evaluated using a multiple linear regression model.
Results
The patients’ mean age±standard deviation was 67.3±11.9 years, and 74.1% were women. One hundred and seventeen (23%) patients had hip fractures, 56 (11%) had vertebral fractures, 127 (25%) had forearm fractures, and 178 (40%) had no fractures. The median (interquartile range) values of HRQOL scores of those with hip, vertebral, and forearm fractures and those with no history of fracture were 0.53 (0.22), 0.60 (0.28), 0.64 (0.26), and 0.64 (0.27), respectively. The multiple regression model revealed a significant relationship between the HRQOL scores and sex, marital status, employment status, presence of any chronic illness in addition to osteoporosis, and type of fracture.
Conclusions
Osteoporosis and its related fractures can reduce the HRQOL.

Citations

Citations to this article as recorded by

1. Long-Term Trends of Distal Radius Fractures in Adults Aged ≥ 50 Years in Korea Using Nationwide Claims Database (2006–2022)
Jae-Hwi Nho, Seong-Jun Kim, Tae-Young Kim, Kyungjun Lim, Jaiyong Kim, Jihye Kim, Hoyeon Jang, Yong-Chan Ha
Journal of Korean Medical Science.2026;[Epub] CrossRef
2. Rehabilitative good clinical practice in the treatment of osteoporosis: a comprehensive review of clinical evidences
Francesco Agostini, Alessandro de Sire, Valerio Sveva, Nikolaos Finamore, Alessio Savina, Andrea Fisicaro, Andrea Bernetti, Valter Santilli, Massimiliano Mangone, Marco Paoloni
Disability and Rehabilitation.2025; 47(16): 4010. CrossRef
3. Cost‑effectiveness analysis of fracture liaison services in Iran
Abdoreza Mousavi, Rajabali Daroudi, Noushin Fahimfar, Afshin Ostovar, Ali Akbari Sari, Mozhdeh Zabihiyeganeh, Mohammad Javad Mansourzadeh, Fatemeh Hajivalizadeh, Bagher Larijani, Alireza Raeisi
Archives of Osteoporosis.2025;[Epub] CrossRef
4. Osteoporotic fractures in adults under 65 without prior indications for BMD testing: a call to reevaluate screening guidelines
Alireza Mirzaei, Mozhdeh Zabihiyeganeh, Pouria Tabrizian, Pegah Heydari, Fahimeh Farajimoghadam
BMC Musculoskeletal Disorders.2025;[Epub] CrossRef
5. Virtual Reality-Based Therapy Improves Balance, Quality of Life, and Mitigates Pain and Fear of Falling in Women with Bone Mineral Density Loss: A Meta-Analysis of Randomized Controlled Trials
Irene Cortés-Pérez, Ángeles Díaz-Fernández, María Catalina Osuna-Pérez, Héctor García-López, Raúl Romero-Del-Rey, Esteban Obrero-Gaitán
Life.2025; 15(11): 1654. CrossRef
6. Hypoglycemic agents and bone health; an umbrella systematic review of the clinical trials’ meta-analysis studies
Pouria Khashayar, Farid Farahani Rad, Ozra Tabatabaei-Malazy, Sara MohammadHosseinzadeh Golabchi, Patricia Khashayar, Mehdi Mohammadi, Sholeh Ebrahimpour, Bagher Larijani
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
7. Editorial: Community series - reducing the burden of age-related disease in relation to osteoporosis, sarcopenia and osteosarcopenia, volume II
Ozra Tabatabaei-Malazy, Patricia Khashayar, Arshed Ali Quyyumi, Iraj Nabipour, Mohammad Hossein Dabbaghmanesh, Leith Zakraoui, Bagher Larijani
Frontiers in Medicine.2023;[Epub] CrossRef

5,330 View
112 Download
Crossref

Seasonal Variations and Common Places of Hip Fractures in Elderly Patients: Nine Year Consecutive Survey: Kyung-A Choi, Yong-Chan Ha, Kyung-Hag Lee; J Bone Metab 2023;30(1):103-114.
Published online February 28, 2023; DOI: https://doi.org/10.11005/jbm.2023.30.1.103

Background
Fall prevention is important for reducing hip fractures. The aim of this study was to determine the relationship between variables related to hip fractures according to sex and season.
Methods
This study included patients admitted for fragility hip fractures between 2012 and 2021. Patients were interviewed by a junior resident before discharge. Data on sex, age, diagnosis, osteoporosis treatment, direction, voiding problems, ambulatory function, seasons, weather, time of day, place, location, floor condition, activity during fall, and perceived reason for fall were collected and analyzed.
Results
A total of 1,118 patients were included (279 males and 839 females). In both sexes, indoor falls were prevalent throughout all seasons, but males showed a higher proportion of outdoor falls, especially in winter during cloudy or snowy weather. Rooms and walking were the most common locations and activities during falls. The poor ambulatory function was associated with a higher prevalence of indoor falls. Osteoporosis treatment rates were low and did not differ according to Koval stage. Winter was associated with higher osteoporosis non-treatment group. Urgency/incontinence in female patients caused a higher proportion of falls during the evening time.
Conclusions
Strategies for indoor fall prevention and vigilant osteoporosis diagnosis and treatment are important for all seasons, especially for frail elderly patients. Outdoor fall prevention emphasized for male patients, and education around nighttime falls should be provided for female patients with voiding dysfunction.

Citations

Citations to this article as recorded by

1. Causes of Reoperations After Primary Total Hip Arthroplasty: A Retrospective Cohort Study Over 20 Years
Ki-Tae Park, Dong-Hoon Lee, Joon-Hwan An, Jong-Hwa Won, Kyung-Hoi Koo, Jung-Wee Park, Young-Kyun Lee
The Journal of Arthroplasty.2025; 40(9): 2338. CrossRef
2. Relationship Between Sural Nerve Function, Physical Function, and the Ability to Perform Activities of Daily Living in Hospitalized Elderly Patients With Proximal Femoral Fractures: A Prospective Observational Study
Eisuke Takeshima, Akira Kimura
Cureus.2025;[Epub] CrossRef
3. Weather and hip fractures: A nine-year study across England and Wales
Louis J Koizia, Kjeld Jensen, David Yearling, Gav Barang, Benjamin HL Harris, Michael B Fertleman
Injury.2025; 56(12): 112856. CrossRef
4. Indoor falls-related hip and femur fractures decreased during the social distancing period of COVID-19 in South korea: a single-center retrospective cohort study using propensity score matching
Kwan Kyu Park, Byung Woo Cho, Hyuck Min Kwon, Woo-Suk Lee, Kyoung-Tak Kang, Jun Young Park
Aging Clinical and Experimental Research.2025;[Epub] CrossRef