jbm > Volume 28(2); 2021 > Article |
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Funding
This study was supported by a research fund (2020IT0001-1) from Asan Institute for Life Science, Asan Medical Center, Republic of Korea.
Variables | Primary DRF group (N=203) | Subsequent DRF group (N=24) | P-value |
---|---|---|---|
Age (yr) | 64.7±10.3 | 68.4±8.2 | 0.091 |
Body mass index (kg/m2) | 23.3±3.1 | 23.4±3.1 | 0.969 |
Hypertension | 85 (41.9%) | 9 (37.5%) | 0.681 |
Dyslipidemia | 84 (41.4%) | 7 (29.2%) | 0.248 |
Diabetes mellitus | 22 (10.8%) | 3 (12.5%) | 0.734 |
Stroke history | 12 (5.9%) | 1 (4.2%) | 0.999 |
Renal insufficiency | 7 (3.4%) | 0 (0.0%) | 0.999 |
Thyroid or parathyroid disease | 22 (10.8%) | 2 (8.3%) | 0.999 |
Rheumatoid arthritis | 9 (4.4%) | 1 (4.2%) | 0.999 |
Asthma | 5 (2.5%) | 4 (16.7%) | 0.009a) |
Malignancy | 21 (10.3%) | 4 (16.7%) | 0.314 |
Steroid medication history | 11 (5.4%) | 0 (0.0%) | 0.612 |
Proton pump inhibitor medication history | 10 (4.9%) | 3 (12.5%) | 0.146 |
Smoking history | 2 (1.0%) | 0 (0.0%) | 0.999 |
Osteoporosis medication history | 39 (19.2%) | 10 (41.7%) | 0.011a) |
Vitamin D medication history | 88 (43.3%) | 11 (45.8%) | 0.817 |
Calcium medication history | 24 (11.8%) | 2 (8.3%) | 0.999 |
Variables | Initial DRF group (N=203) | Subsequent DRF group (N=24) | P-value |
---|---|---|---|
Lumbar BMD (g/cm2) | 0.910±0.145 | 0.918±0.124 | 0.682 |
Femur neck BMD (g/cm2) | 0.742±0.115 | 0.748±0.108 | 0.835 |
Trochanter BMD (g/cm2) | 0.618±0.103 | 0.639±0.111 | 0.369 |
Total hip BMD (g/cm2) | 0.790±0.116 | 0.808±0.109 | 0.456 |
Lowest T score in DXA | −2.3±1.0 | −2.1±0.8 | 0.351 |
Osteoporosis | 82 (40.4%) | 7 (29.2%) | 0.378 |
Trabecular bone score | 1.366±0.082 | 1.367±0.090 | 0.594 |
HAL (mm) | 100.9±5.1 | 100.6±4.8 | 0.762 |
NSA (˚) | 125.1±4.1 | 125.5±3.3 | 0.444 |
Cortical width (mm) | 4.6±1.5 | 4.6±1.2 | 0.663 |
CSA (cm2) | 108.3±17.3 | 107.4±17.8 | 0.795 |
CSMI (cm4) | 6,969.5±1,642.5 | 6,396.1±1,624.3 | 0.209 |
SM (cm3) | 421.1±87.7 | 393.4±97.1 | 0.149 |
BR | 4.1±1.6 | 3.8±1.0 | 0.580 |
Mean bicortical thickness of distal radius (mm) | 5.0±0.9 | 5.1±0.8 | 0.471 |
10 years probability of major osteoporotic fracture on FRAX (%) | 7.5±4.1 | 10.8±4.3 | <0.001a) |
10 years probability of hip fracture on FRAX (%) | 2.5±2.7 | 3.3±2.6 | 0.050 |
Variables | Initial DRF group (N=48) | Subsequent DRF group (N=24) | P-value |
---|---|---|---|
Age (yr) | 67.9±9.2 | 68.4±8.2 | 0.830 |
Body mass index (kg/m2) | 24.0±3.3 | 23.4±3.1 | 0.438 |
Lumbar BMD (g/cm2) | 0.913±0.135 | 0.918±0.124 | 0.877 |
Femur neck BMD (g/cm2) | 0.724±0.116 | 0.748±0.108 | 0.410 |
Trochanter BMD (g/cm2) | 0.613±0.103 | 0.639±0.111 | 0.334 |
Total hip BMD (g/cm2) | 0.771±0.121 | 0.808±0.109 | 0.212 |
Lowest T score in DXA | −2.4±1.0 | −2.1±0.8 | 0.290 |
Osteoporosis | 17 (35.4%) | 7 (29.2%) | 0.791 |
Trabecular bone score | 1.352±0.093 | 1.367±0.090 | 0.313 |
HAL (mm) | 101.1±5.1 | 100.6±4.8 | 0.538 |
NSA (˚) | 124.9±5.0 | 125.5±3.3 | 0.594 |
Cortical width (mm) | 4.6±1.7 | 4.6±1.2 | 0.684 |
CSA (cm2) | 106.6±17.2 | 107.4±17.8 | 0.856 |
CSMI (cm4) | 7,018.2±1,525.3 | 6,396.1±1,624.3 | 0.115 |
SM (cm3) | 419.0±77.1 | 393.4±97.1 | 0.227 |
BR | 4.3±2.1 | 3.8±1.0 | 0.459 |
Mean bicortical thickness of distal radius | 4.9±1.0 | 5.1±0.8 | 0.280 |
Osteoporosis medication history | 17 (35.4%) | 7 (29.2%) | 0.596 |
Asthma | 1 (2.1%) | 4 (16.7) | 0.039a) |
10 years probability of major osteoporotic fracture on FRAX (%) | 8.4±4.3 | 10.8±4.3 | 0.009a) |
10 years probability of hip fracture on FRAX (%) | 3.0±2.9 | 3.3±2.6 | 0.437 |
Jae Kwang Kim
https://orcid.org/0000-0001-5104-4634
Minyoung Oh
https://orcid.org/0000-0002-6840-3215
Young Ho Shin
https://orcid.org/0000-0002-9388-9720