| The Association of Oophorectomy Status and the Change of Bone Mineral Density in Hysterectomized Perimenopausal Women |
| 갱년기 여성에서 전자궁적출술시 난소절제술 시행여부와 골밀도 변화의 상관관계 |
| 천근영,동서연,국일영,정재은,김미란,임용택,조현희,권동진,유영옥,김은중,김장흡,이진우,김진홍 |
| 가톨릭대학교 의과대학 산부인과학교실 |
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| Abstract |
Objective
The relationship between a hysterectomy and oophorectomy according to the changes in the bone mineral density (BMD) was examined in perimenopausal women undergoing estrogen replacement therapy.
Methods
Women aged 43~51 years attended the out-patient clinic at the department of obstetrics and gynecology, Kangnam St. Marys Hospital from April 1997 to March 2002 to determine if a hysterectomy and oophorectomy is required. A spine and hip BMD was assessed with DEXA at before and approximately 2 years after surgery. The subjects were divided into three groups according to the oophorectomy status. (group 1: hysterectomy only, n=15; group 2: hysterectomy with unilateral oophorectomy, n=14; group 3: hysterectomy with bilateral oophorectomy, n=16).
Results
Preoperatively, there was a significant difference in the BMD of the spine and femur, and the estrogen level between the groups (p<0.05). However, 2 years after surgery, there were no difference according to the oophorectomy status in the BMD and % change in the BMD of the spine and femur. The interval between surgery and the start of hormone replacement therapy (HRT) in group 1 was 2.35 years, 1.25 years in group 2, and 0.67 years in group 3.
Conclusion
There was no difference in the level of bone loss by hysterectomy with or without an oophorectomy for 2 years. HRT beginning a short time after the hysterectomy or an oophorectomy can minimize the loss of bone that occurs normally during those years.
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| Key Words:
Bone loss, Bone mineral density, Premenopausal hysterectomy, Oophorectomy |
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